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A kind of lactone compound, its preparation method and application

A compound and lactone technology, applied in the field of tobacco chemistry, can solve problems such as no related reports, and achieve the effects of novel structure, improved smoking quality of cigarettes, good physical and sensory moisturizing effects

Active Publication Date: 2018-01-12
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In my country's cigarette industry, glycerin, propylene glycol, sorbitol and other polyhydroxy substances are mainly used as humectants. The main purpose of humectants is to maintain the moisture content of shredded tobacco during processing and improve the processing resistance of shredded tobacco. The smoking comfort of finished cigarettes is closely related to its formula structure and flavoring. Through separation, a lactone compound with the function of improving the smoking quality of cigarettes is obtained. This compound cooperates with a humectant to improve the smoking of cigarettes. Quality has not been reported

Method used

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  • A kind of lactone compound, its preparation method and application
  • A kind of lactone compound, its preparation method and application
  • A kind of lactone compound, its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0031] A kind of lactone compound C 13 h 14 o 3 The preparation method specifically comprises the following steps:

[0032] (1) Preparation of tobacco extract extract: taking air-dried tobacco leaves as raw material, pulverizing or cutting the tobacco leaves into small pieces, soaking and extracting the tobacco leaves 4 times with the first solvent, each time for 54 hours, after merging the extracts, filtering and concentrating Obtain the tobacco extract extract; wherein the first solvent is a mixture of an organic solvent selected from methanol, ethanol or acetone and water, when the first solvent is a mixture of methanol or ethanol and water, wherein methanol or Ethanol accounts for 95wt% of the first solvent, and when the first solvent is a mixture of acetone and water, wherein acetone accounts for 70wt% of the first solvent; and the first solvent:tobacco=3:5, weight ratio;

[0033] (2) Silica gel column chromatography: after dissolving the second solvent selected from p...

Embodiment 2

[0037] The air-cured tobacco samples used come from Tengchong, Yunnan, and the variety is Tengchong Tengruan Raw Tobacco. Sampling 2.0 kg of tobacco leaves and pulverizing them, extracting 5 times with 95% methanol for 24 hours each time, combining the extracts, filtering, and concentrating under reduced pressure to obtain 95 g of tobacco extract extract. After dissolving the above-mentioned tobacco extract extract with pure methanol of 2.0 weight multiples, mix the sample with 100 mesh thick silica gel of 120g, then mix with 0.6kg of 160 mesh silica gel and carry out silica gel column chromatography with a volume ratio of 1:0, 20:1, 9:1, 8:2, 7:3, 6:4, 1:1, 1:2 chloroform-acetone gradient elution, TLC monitoring Merge the same fractions to get 8 fractions , wherein the chloroform-acetone eluted part with a volume ratio of 8:2 was separated by Agilent 1100 semi-preparative high performance liquid chromatography, with 54% methanol as mobile phase, Zorbax SB-C 18 (21.2×250mm, 5...

Embodiment 3

[0040] The air-cured tobacco samples used were from Dali, Yunnan, and the variety was Yunlong Tiandeng tobacco. Sampling 3.5 kg of tobacco leaves and chopping them up, extracting 4 times with 95% ethanol for 48 hours each time, combining the extracts, filtering, and concentrating under reduced pressure to obtain 245 g of tobacco extract extract. The above-mentioned tobacco extract extract is dissolved with its 2.0 weight times of pure methanol and mixed with 250g of 80 mesh thick silica gel, then mixed with 1.2kg of 200 mesh silica gel and then packed into a column for silica gel column chromatography, with a volume ratio of 1:0, 20:1, 9:1, 8:2, 7:3, 6:4, 1:1, 1:2 chloroform-acetone gradient elution, TLC monitoring Merge the same fractions to get 8 fractions , wherein the chloroform-acetone elution part with a volume ratio of 8:2 was separated by Agilent 1100 semi-preparative high-performance liquid chromatography, with 54wt% methanol as mobile phase, Zorbax SB-C 18 (21.2×250...

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Abstract

The present invention discloses a novel lactone compound, which has a structure specified in the description. The compound is named as 8, 9-dihydro-7, 7-methyl-1H furan [3, 4-f]-chromene 3(7H)-ketone. The molecular formula of the compound is C13H14O3. The invention also discloses a preparation method of the above compound and the application thereof in improving the smoking quality of cigarettes.

Description

technical field [0001] The invention belongs to the technical field of tobacco chemistry, in particular to a lactone compound extracted from air-cured tobacco for the first time. At the same time, the present invention also relates to the preparation method of the compound and its combined application with a humectant to improve the smoking quality of cigarettes. Background technique [0002] Tobacco is the plant with the most complex chemical composition in the world, and its secondary metabolites are very rich. After decades of research, more than 3,000 monomeric chemical substances have been identified from tobacco, and many components have not yet been identified. come out. Although smoking is widely recognized as harmful to health, tobacco still has a strong appeal to thousands of consumers. In addition to the addictive properties of nicotine, the rich flavor substances in tobacco also play an important role. [0003] Lactone refers to the ester compound formed by the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/04A24B15/40
CPCA24B15/403C07D493/04
Inventor 唐石云申钦鹏刘春波张天栋周博赵英良姚守拙刘志华张凤梅何沛杨光宇缪明明陈永宽
Owner CHINA TOBACCO YUNNAN IND
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