Monosaccharide-like glycylated sugar alcohol compositions for use as anti-diabetic drugs

A composition and technology for diabetes, which are applied to the application of novel monosaccharide-like glycinated sugar alcohol compositions in the design and development of anti-diabetic drugs, and can solve the problems of unsafe drugs/substances or sugar substitutes and the like

Inactive Publication Date: 2017-02-15
林希龙 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In conclusion, there is currently no safe drug/medicine or sugar substitut

Method used

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  • Monosaccharide-like glycylated sugar alcohol compositions for use as anti-diabetic drugs
  • Monosaccharide-like glycylated sugar alcohol compositions for use as anti-diabetic drugs
  • Monosaccharide-like glycylated sugar alcohol compositions for use as anti-diabetic drugs

Examples

Experimental program
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Embodiment

[0042] In the following experimental disclosures, the abbreviations used are as follows: M (mole, molar); mM (millimole, millimolar); μm (micromole, micromolar); mol (mole, moles); ear, picomole); gm (gram, grams); mg (milligram, milligrams); μg (microgram, micrograms); ng (nanogram, nanograms); L (liter, liters); ml (milliliter, milliliters); μl ( Microliters, microliters); ℃ (degrees Celsius, degreesCentigrade); RNA (ribonucleic acid, ribonucleic acid); DNA (deoxyribonucleic acid, deoxyribonucleic acid); dNTP (deoxyribonucleoside triphosphate, deoxyribonucleotide triphosphate); PBS (phosphate Buffer, phosphate buffered saline); NaCl (sodium chloride, sodium chloride); HEPES (N-2-hydroxyethylpiperazine-N-2-ethanesulfonic acid, N-2-hydroxyethylpiperazine-N-2-ethanesulfonic acid); HBS (HEPES buffer, HEPES buffered saline); SDS (sodium dodecyl sulfate, sodiumdodecylsulfate); Tris-HCl (tris-hydroxymethylaminomethane-hydrochloride, tris-hydroxymethylaminomethane-hydrochloride); AT...

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Abstract

This invention is related to a sugar-like chemical composition for use in diabetes therapy. Particularly, the present invention teaches the use of monosaccharide-like glycylated sugar alcohol compounds to block or reduce sugar absorption in diabetes patients, so as to prevent the risk of hyperglycemia symptoms. The novelty of the present invention is that glycylated sugar alcohols were found to be useful for treating Diabetes mellitus. In addition, the present application discloses a method for producing these glycylated sugar alcohols. In sum, the present invention includes not only a kind of sugar-like chemical composition for use in treating diabetes but also discloses a state-of-the-art protocol and methodology for producing such a composition via glycylation of sugars and sugar alcohols.

Description

[0001] inventor: [0002] Lin Xilong (Arcadia, CA), Lin Yixiu (Arcadia, CA), Lin Yixiu (Irvine, CA), and Zhang Qinci (Cerritos, CA). [0003] priority: [0004] The present invention claims the U.S. Provisional Application No. 61 / 931,650 filed on January 26, 2014, entitled "Composition and Formulation of Sugar-Alcohol Complex for In vitro and In vivo Delivery of Nucleic Acid Drugs" as its priority. This application also claims priority to U.S. Provisional Application No. 62 / 050,107, filed September 13, 2014, entitled "Novel Monosaccharide-like Glycinated Sugar Alcohol Compositions for the Treatment of Diabetes" . The present invention also claims priority to US Application No. 14 / 457,829, filed August 12, 2014, entitled "Novel Sugar Alcohol-Based Compositions for In vivo and In Vitro Delivery of Nucleic Acid-Based Drugs." This application also claims priority to US Application No. 62 / 054,981, filed September 25, 2014, entitled "Novel Monosaccharide-like Glycinated Sugar Alco...

Claims

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Application Information

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IPC IPC(8): A61K31/223A61K31/7032A61K8/41A61K8/60A61P3/04A61P3/10A61Q19/06
CPCA61K31/7032A61P3/04A61P3/10
Inventor 林希龙林羿秀林怡彣张钦次
Owner 林希龙
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