Preparation method of peramivir powder

A technology of peramivir powder and mivir powder, which is applied in the field of preparation of peramivir powder, can solve the problems of uneven particle size, excessive particle size difference, triggering asthma, etc., and achieve uniform powder particle size and good effect Good, good dispersion effect

Inactive Publication Date: 2017-02-22
默栢瑞成都生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Considering that peramivir can only achieve the drug effect through injection at present, and injection treatment can only be carried out in hospitals, and cannot be used on a large scale
However, as a new type of anti-influenza virus drug, the peramivir powder of the production powder has many difficulties. At first, as the peramivir powder that works by inhalation, there are strict re

Method used

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  • Preparation method of peramivir powder
  • Preparation method of peramivir powder

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preparation example Construction

[0017] A preparation method of peramivir powder, comprising steps:

[0018] A, take raw material peramivir;

[0019] B, dry the raw material peramivir taken in step A, grind, pass through 500 mesh sieve, 800 mesh sieve successively, get -500~+800 mesh particles to obtain dried peramivir;

[0020] C. Micronizing the dried raw material in step B in a jet mill to obtain a micronized powder;

[0021] D. Pass the micronized powder obtained in step C through a 1000 mesh sieve to obtain micronized peramivir powder.

[0022] The particle size of the micronized peramivir powder obtained after passing the obtained micronized powder through a 1000-mesh sieve is within a reasonable range.

[0023] A further improvement is that the temperature of the drying treatment in the step B is 30-50° C., and the drying time is 12-24 hours.

[0024] A further improvement is that the temperature of the drying treatment in step B is 30° C., and the drying time is 24 hours.

[0025] A further improv...

Embodiment 1

[0030] A preparation method of peramivir powder, comprising steps:

[0031] A, take raw material peramivir;

[0032] B. Dry the peramivir raw material weighed in step A at 30°C for 24 hours, grind, pass through a 500-mesh sieve and an 800-mesh sieve in turn, and take -500 to +800 mesh granules to obtain dried peramivir ;

[0033] C. Micronize the peramivir obtained in step B in a jet mill, and set the pulverization particle size of the jet mill to 1.0-5.0 μm to obtain micronized peramivir powder.

[0034] D. Pass the micronized powder obtained in step C through a 1000 mesh sieve to obtain micronized peramivir powder.

Embodiment 2

[0036] A preparation method of peramivir powder, comprising steps:

[0037] A, take raw material peramivir;

[0038] B. Dry the peramivir raw material weighed in step A at 50°C for 12 hours, grind, pass through a 500-mesh sieve and an 800-mesh sieve in turn, and take -500 to +800 mesh granules to obtain dried peramivir ;

[0039] C. Micronize the peramivir obtained in step B in a jet mill, and set the pulverization particle size of the jet mill to 1.0-5.0 μm to obtain micronized peramivir powder.

[0040] D. Pass the micronized powder obtained in step C through a 1000 mesh sieve to obtain micronized peramivir powder.

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Abstract

The invention belongs to the technical field of medicine production, particularly relates to a preparation method of peramivir powder, and aims at solving the technical problem that in the prior art, due to the fact that the particle size is not uniform and large in difference, body discomfort of a user is prone to be caused. The preparation method of the peramivir powder comprises the steps that 1, a peramivir raw material is weighed; 2, the peramivir raw material weighed in the step 1 is subjected to drying treatment, ground and screened with a 500-mesh screen and a 800-mesh screen in sequence, particles with the particle size ranging from minus 500 mesh to 800 mesh are taken, and dried peramivir is obtained; 3, the raw material obtained after drying treatment in the step 2 is micronized in an airflow pulverization instrument, and micronized powder is obtained; 4, the micronized powder obtained in the step 3 is screened with a 1,000-mesh screen, and then the micronized peramivir powder is obtained. According to the preparation method of the peramivir powder, the peramivir powder obtained after the peramivir raw material is dried, micronized in the airflow pulverization instrument and screened is adopted, and the requirements of the European pharmacopoeia and the united state pharmacopoeia on bulk drugs of a dry powder inhalant are met.

Description

technical field [0001] The invention belongs to the technical field of medicine production, in particular to a preparation method of peramivir powder. Background technique [0002] As a newly listed anti-influenza virus drug, peramivir has a long half-life in the human body, can be taken in a very small dose, and has high efficiency and safety. Peramivir for injection has been approved for marketing in Japan and South Korea. In the United States, peramivir for injection has also been approved for marketing. After my country approved peramivir for injection in 2013, it became the drug of choice for the treatment of H7N9. As a newly listed anti-influenza virus drug, peramivir has a long half-life in the human body, can be taken in a very small dose, and has high efficiency and safety. Considering that peramivir can only achieve the drug effect through injection at present, and injection treatment can only be carried out in hospitals and cannot be used on a large scale. How...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K9/72A61K31/196A61P31/16
CPCA61K9/14A61K9/0073A61K31/196
Inventor 张洋
Owner 默栢瑞成都生物技术有限公司
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