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Application of vitexin to preparation of medicines for prevention and/or treatment of malignant tumors

A malignant tumor, vitexin technology, applied in the field of antitumor drugs, can solve the problems of unreported vitexin malignant tumors, etc., and achieves the effects of fast action speed, good application and good therapeutic effect

Active Publication Date: 2017-02-22
合肥七星医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the prior art does not report the application of vitexin in the treatment of malignant tumors, especially in lung cancer and sarcoma.

Method used

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  • Application of vitexin to preparation of medicines for prevention and/or treatment of malignant tumors
  • Application of vitexin to preparation of medicines for prevention and/or treatment of malignant tumors
  • Application of vitexin to preparation of medicines for prevention and/or treatment of malignant tumors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Preparation of Vitexin Injection

[0026] a. Weigh vitexin 3g, mannitol 180g raw materials and mix evenly, add 600ml water for injection, stir evenly, add 0.1mol / L sodium hydroxide solution 1500ml, stir to dissolve, then adjust to 1mol / L hydrochloric acid solution When the pH is 8.5, add water for injection to 3000ml, add 0.05% activated carbon for needles, stir for 10 minutes, decompress and coarsely filter with a microporous titanium filter, decarbonize, check the content and pH, and then pass through a 0.22μm microporous membrane terminal After filtration, it is divided into 10ml vials, each bottle is filled with 3ml, and then freeze-dried at low temperature.

[0027] b. Pre-freezing: Put the subpackaged medicines on the inner shelf of the freeze-drying box and start to pre-freeze to +25°C ~ -40°C for 2 hours; -40°C for 3 hours.

[0028] c. Sublimation drying: Lower the temperature of the condenser to below -45°C, start the vacuum pump, and when the vacuum reaches a...

Embodiment 2

[0031] Preparation of Vitexin Injection

[0032] a. Weigh 30g vitexin and 180g mannitol and mix them evenly, add 600ml water for injection, stir evenly, then add 1500ml 0.1mol / L sodium hydroxide solution, stir to dissolve, then adjust to 1mol / L hydrochloric acid solution When the pH is 8.5, add water for injection to 3000ml, add 0.05% activated carbon for needles, stir for 10 minutes, decompress and coarsely filter with a microporous titanium filter, decarbonize, check the content and pH, and then pass through a 0.22μm microporous membrane terminal After filtration, it is divided into 10ml vials, each bottle is filled with 3ml, and then freeze-dried at low temperature.

[0033] b. Pre-freezing: Put the subpackaged medicines on the inner shelf of the freeze-drying box and start to pre-freeze to +20°C ~ -40°C for 3 hours; -40°C for 4 hours.

[0034] c. Sublimation drying: Lower the temperature of the condenser to below -45°C, start the vacuum pump, and when the vacuum reaches a...

Embodiment 3

[0037] Preparation of Vitexin Injection

[0038] a. Weigh 60g of vitexin and 240g of mannitol and mix them evenly, add 600ml of water for injection, stir evenly, add 1500ml of 0.1mol / L sodium hydroxide solution, stir and dissolve, then adjust to 1mol / L hydrochloric acid solution When the pH is 8.5, add water for injection to 3000ml, add 0.05% activated carbon for needles, stir for 10 minutes, decompress and coarsely filter with a microporous titanium filter, decarbonize, check the content and pH, and then pass through a 0.22μm microporous membrane terminal After filtration, it is divided into 10ml vials, each bottle is filled with 3ml, and then freeze-dried at low temperature.

[0039] b. Pre-freezing: Put the subpackaged medicines on the inner shelf of the freeze-drying box and start to pre-freeze to +25°C ~ -40°C for 2 hours; -40°C for 3 hours.

[0040] c. Sublimation drying: Lower the temperature of the condenser to below -45°C, start the vacuum pump, and when the vacuum r...

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Abstract

The invention belongs to the technical field of antitumor medicines and relates to application of vitexin to preparation of medicines for prevention and / or treatment of malignant tumors. A structural formula I of the vitexin is as shown in the specification. The medicines prepared from the vitexin are excellent in malignant tumor resistance.

Description

technical field [0001] The invention relates to the technical field of antitumor drugs, in particular to the application of vitexin in the preparation of drugs for preventing and / or treating malignant tumors. Background technique [0002] Lung cancer is one of the malignant tumors with the fastest increasing morbidity and mortality and the greatest threat to the health and life of the population. In the prior art, Western medicine chemotherapeutic drugs and traditional Chinese medicines are often used in the treatment of lung cancer. Commonly used traditional Chinese medicines with good curative effect on non-small cell lung cancer include Shenlian Capsule, Yifei Qinghua Granule, Qingfei Sanjie Pill, etc.; commonly used Chinese medicine with good curative effect on small cell lung cancer, Yifei Qinghua Paste and Yifei Qinghua Granule , Qingfei Sanjie Pills, etc. [0003] Hawthorn leaf (Crataegus pinnatifida) belongs to the Rosaceae plant. It tastes sour and flat in nature....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K9/08A61K47/10A61P35/00
CPCA61K9/0019A61K9/08A61K31/352A61K47/10
Inventor 牛海军邵旭李晓亮
Owner 合肥七星医药科技有限公司