Parametric design method of defective skull tissue engineering vascular stent on the basis of microscope CT (Computed Tomography) measurement

A parametric design, vascular stent technology, applied in the field of tissue engineering, can solve problems such as limiting cell growth and osteogenesis

Inactive Publication Date: 2017-02-22
TIANJIN UNIV
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Problems solved by technology

[0004] In order to solve the problems in the prior art, the present invention provides a parametric design method for skull tissue engineering vascular scaffolds based on micro-CT measurement, which solves the problem that the skull tissue engineering scaffolds in the prior art limit the growth of cells due to the lack of vascular structures. The problem of bone mass formation

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  • Parametric design method of defective skull tissue engineering vascular stent on the basis of microscope CT (Computed Tomography) measurement
  • Parametric design method of defective skull tissue engineering vascular stent on the basis of microscope CT (Computed Tomography) measurement
  • Parametric design method of defective skull tissue engineering vascular stent on the basis of microscope CT (Computed Tomography) measurement

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Embodiment 1

[0108] The value of embodiment 1 parameter is as shown in table 3, and design result is as follows Figure 8 shown. The model consists of a total of 111 vessel segments, and the volume of the main vessel is 461.63mm 3 , the total volume of blood vessels is 928.33mm 3 , the blood vessel density in this space is 8.59%.

[0109] Table 3 Example One Vessel Model Design Parameters

[0110]

Embodiment 2

[0111] Example 2 In order to show the different influences of the node segment length d and the main branch angle θ on the distribution of binary tree nodes, the range of θ and d is reduced within a reasonable range, as shown in Table 4, and the design results are as follows Figure 9 shown. Example 2 consists of 136 blood vessel segments, and the volume of the main blood vessel is 425.10mm 3 , the total volume of blood vessels is 921.27mm 3 , the vessel density in the space is 8.53%.

[0112] Table 4 example two vessel model design parameters

[0113]

[0114] From the above two examples, it can be seen that the main vessel volume, total volume and vessel density obtained by the two sets of parameters are not much different, the main vessels are relatively evenly distributed in space, and the small vessels can also fully fill the space between the main vessels. The voids effectively increase the density of blood vessels in the space. Reducing the range of θ and d will ...

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Abstract

The invention discloses a parametric design method of defective skull tissue engineering vascular stent on the basis of microscope CT (Computed Tomography) measurement. Through microscope CT, a natural skull sample is scanned, a vein structure in a diploe is reconstructed, morphological characteristics, including the furcation, the movement direction, the pipe diameter and the like, of a vein vessel can be extracted, a parametric model of the vessel is established according to the morphological characteristics, the structure of the vessel can be quickly and flexibly designed, the parametric model is suitable for the stent of any size, and a foundation can be laid for realizing the vascularization of the skull tissue engineering stent.

Description

technical field [0001] The invention belongs to the technical field of tissue engineering, and in particular relates to a parametric design method of a skull tissue engineering vascular stent based on micro-CT measurement. Background technique [0002] The bioactive artificial bone substitute developed by bone tissue engineering technology can repair and reconstruct the damaged skull tissue, thereby maintaining or improving the function and structure of the skull, and has a good clinical application prospect. However, in the in vitro cell integration study of the skull porous scaffold, it was found that the survival rate of bone cells was low and the osteogenesis was slow, especially for large-area scaffolds, a large number of cells died in the center of the first week of implantation, the main reason The problem of vascularization is not considered in the scaffold. There is no vascular structure in the scaffold, and the blood supply and oxygen supply of the cells are limite...

Claims

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Application Information

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IPC IPC(8): G06F17/50G06T17/30
CPCG06F30/20G06T17/30G06T2211/404
Inventor 郑淑贤李佳刘洁
Owner TIANJIN UNIV
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