Unlock instant, AI-driven research and patent intelligence for your innovation.

Coatings for medical devices

A technology of coating and therapeutic agent, which can be used in coatings, balloon catheters, anti-tumor drugs, etc., and can solve problems such as difficulty in drug delivery

Inactive Publication Date: 2017-02-22
SPECTRANETICS
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Efficacy of systemic drug therapy in these diseases may be limited by inadequate drug delivery to diseased tissues and / or dose-limiting histotoxic effects in nondiseased tissues
Local delivery of drugs to diseased tissues in body cavity walls can be difficult

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Coatings for medical devices
  • Coatings for medical devices
  • Coatings for medical devices

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0111] In short, the balloon catheter is coated as follows. The balloon catheter is taken out of its packaging, the protective sheath is removed, and the balloon is expanded to approximately 3 atmospheres with air. Optionally, pre-condition the balloon catheter (clean with isopropanol, then air-dry and / or argon-plasma treatment). The balloon catheter was dip-coated at 70°F at a 90° angle into the above coating solution to the nominal paclitaxel dose listed in Table 1 below. The balloon catheter was rotated at 58 ± 2 rpm during the coating process. Allow the balloon catheter to dry for 5 minutes to 24 hours, then inspect the balloon, fold, sheath, and sterilize with ethylene oxide.

[0112] The coating formulation of the present disclosure is prepared according to the above method. The "A" coating solution was serially diluted with a solvent (azeotrope) to produce a "B-D" formulation (see Table 1 below).

[0113] For each of the 12 coating formulations of this example and the re...

Embodiment 2

[0149] Covidien / ev3 NANOCROSS TM A 0.014" balloon catheter (4×40mm) was used in this study.

[0150] The balloon was dip-coated into the 3B coating formulation described above.

[0151] The effects of plasma treatment, balloon cleaning, wetting, and Fr. size on the appearance, integrity and rapid paclitaxel uptake of the coating into the porcine carotid tissue on the experimental bench model in Example 1 were evaluated.

[0152] The devices are divided into eight (8) groups (see sample matrix in Table 5 below).

[0153] Fifty-eight (58) devices were evaluated, with the following parameters changed:

[0154] ●Small 3.5 (Fr) and large 4.5 (Fr) balloon protective sleeves;

[0155] ●IPA cleaning + 60 seconds ultrasonic treatment compared to uncleaned balloon;

[0156] ●120 seconds is relative to 30 seconds plasma treatment;

[0157] ●Wetting versus non-wetting; and

[0158] ●Single expansion is relative to multiple expansions.

[0159] Groups A, B, E, and F were cleaned with 99.5% IPA and soni...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Thicknessaaaaaaaaaa
Molecular weightaaaaaaaaaa
Login to View More

Abstract

A method and device for local delivery of a water-insoluble therapeutic agent to the tissue of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with a non-durable coating which includes an amphiphilic polymer or copolymer, in embodiments polyethylene glycol, having a substantially water-insoluble therapeutic agent dispersed therein. In some embodiments, the coating may also include iodine. The medical disposable device is inserted into a body lumen, and expanded to contact the non-durable coating against the body lumen and deliver the substantially water-insoluble therapeutic agent to the body lumen tissue.

Description

Technical field [0001] The present disclosure provides coatings for medical devices and the delivery of therapeutic agents therefrom. In embodiments, the present disclosure relates to methods and devices for the local delivery of water-soluble or water-insoluble therapeutic agents to the surface of normal or diseased body cavities. Background technique [0002] Sporadic, genetic, environmental and iatrogenic diseases related to significant morbidity and mortality occur in the body cavity walls of the endothelial cell lining and epithelial cell lining. For example, atherosclerosis and postoperative restenosis occur in the arterial wall. Adenocarcinoma, esophageal varices, and bile duct epithelial cancer occur in the gastrointestinal wall. [0003] The efficacy of systemic drug therapy for these diseases may be limited by insufficient drug delivery from diseased tissues and / or dose-limiting tissue toxicity of non-diseased tissues. The local delivery of drugs to diseased tissues in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L29/08A61L29/16
CPCA61L2300/106A61L2300/416A61L29/085A61L29/16A61P35/00C08L71/02A61M25/1002A61L2420/06A61M2025/1075A61M2025/105A61M25/10
Inventor P·鲁阿尼C·威尔逊S·乌麦尔A·阿尔坎塔拉J·J·汉考克Z·齐
Owner SPECTRANETICS