Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Synthesis and resolution of 6-methoxy-1-aminotetralin

A technology of methoxyl and tetralamine, applied in the field of synthesis and resolution of chiral amines, to achieve the effects of simple operation, high purity and good product yield

Inactive Publication Date: 2017-03-08
王际宽
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be found through the research literature that there is no information about how to use kinetics and dynamic kinetics to resolve and prepare R-6-methoxyl-1-tetralamine

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Synthesis and resolution of 6-methoxy-1-aminotetralin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] 1) Preparation of 6-methoxy-1-tetralamine

[0008] In a 1000ml autoclave, add 88g of 6-methoxyl-1-tetralone, 600ml of absolute ethanol and 10g of catalyst SN-600P, seal the reaction kettle, use a vacuum pump to remove the air in the kettle, and then fill it with nitrogen to 0.5MPa, Then use a vacuum pump to evacuate; under negative pressure, charge 42.5g of ammonia gas, after the ammonia gas is filled, fill the autoclave with hydrogen to 3.5MPa, and heat up to 90°C for reaction. After reacting for 10 hours, it was found that the hydrogen pressure did not drop any more, so the reaction was stopped. After the temperature of the system dropped to room temperature, the reaction solution was filtered and concentrated to obtain crude 6-methoxy-1-tetralamine. Add the crude product to dilute hydrochloric acid solution while stirring, let it react to generate 6-methoxy-1-tetralamine hydrochloride, and dissolve it in the aqueous solution, and extract the aqueous solution with et...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for preparing racemic 6-methoxy-1-aminotetralin and R-6-methoxy-1-aminotetralin with 6-methoxy-1-tetralone as the raw material. The method specifically includes the steps that 6-methoxy-1-tetralone is subjected to a reductive ammoniation reaction to obtain racemic 6-methoxy-1-aminotetralin, and racemic 6-methoxy-1-aminotetralin is subjected to dynamic kinetic resolution to obtain R-6-methoxy-1-aminotetralin. The method has the advantages that operation is easy, the product yield is high, and the optical purity is high. The method has great guidance and application value in the synthesis and resolution process of 6-methoxy-1-aminotetralin.

Description

technical field [0001] The invention relates to a method for synthesizing and resolving chiral amines, in particular to a method for synthesizing 6-methoxyl-1-tetralamine through a chemical method and further resolving through kinetics. Background technique [0002] 6-methoxy-1-tetralamine as a chiral intermediate. In the existing related research, there are few reports on how to prepare and resolve 6-methoxy-1-tetralamine. It can be found through the research literature that there is no information on how to prepare R-6-methoxy-1-tetralamine by kinetic and dynamic kinetic resolution. [0003] The present invention uses 6-methoxyl-1-tetralone as a raw material to obtain 6-methoxyl-1-tetralamine through reductive amination reaction, and then 6-methoxyl-1-tetralamine is obtained by aliphatic Enzyme-catalyzed kinetic resolution can give 6-methoxy-1-tetralamine. Contents of the invention [0004] The present invention aims to provide a method for synthesizing 6-methoxyl-1-t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C12P13/00C12P41/00
CPCC12P13/001C12P41/007
Inventor 王际宽
Owner 王际宽
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com