Fermented product of fungi strain for treating dementia and application thereof

Abstract

The invention discloses a fermented product of a fungi strain for treating dementia. The fungi strain is separated from endophytic fungi of Huperzia serrata and belongs to fusarium oxysporum NSG-1 strain. After the passage of 20 generations in laboratory, the fungi strain has genetic stability. The amino sequence of the fungi strain is as shown in SEQ ID NO:1. The fungi strain provided by the invention is used as a biologic strain for treating vascular dementia and senile dementia; the excellent high-efficiency expression gene for generating huperzine a is transferred into the strains in other modes; more excellent characteristics can be acquired through gene modification; besides, further optimization for the bacterial strain can be achieved through mutation breeding; the research on the fungi strain has huge significance in biosynthesis industrial production of huperzine a, plant resource protection, settlement for the clinic first-line pharmacy requirement and reduction of medical expense for treating vascular dementia and senile dementia patients.

Description

Technical field [0001] The invention belongs to the technical field of pharmaceutical microorganisms, and specifically relates to a fungal strain used for fermented products to treat dementia. The invention also relates to the application of the fungal strain. Background technique [0002] Alzheimer's disease, also known as Alzheimer's disease (AD) is a neuronal degenerative disease characterized by progressive dementia, mainly manifested as progressive cognitive dysfunction, personality and behavior changes, and memory decline Etc., leading to the death of the patient within 7-10 years after the illness. According to estimates by the International Alzheimer's Association, there were approximately 36 million dementia patients worldwide in 2010, and it is estimated that by 2050, the number of AD patients will reach 115 million. Vascular dementia (Vasculardementia, VD) is an acquired intellectual impairment syndrome caused by brain dysfunction caused by various cerebrovascular dis...

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a fungal strain for the treatment of dementia with a fermentation product, so as to solve the bottleneck of lack of plant resources in obtaining huperzine A from plant extraction; and the chemical synthesis steps are cumbersome and expensive, and it is difficult to obtain pure optically active synthesis object problem

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