Fermented product of fungi strain for treating dementia and application thereof

A fermentation product and dementia technology, applied in the field of pharmaceutical microorganisms, can solve the problems of difficulty in obtaining pure optically active compounds, high cost, lack of plant resources, etc., and achieve the effects of solving the demand for drugs, reducing medical expenses, and protecting plant resources.

Active Publication Date: 2017-03-15
陕西仁达康健医药生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a fungal strain for the treatment of dementia with a fermentation product, so as to solve the bottleneck of lack of plant resources

Method used

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  • Fermented product of fungi strain for treating dementia and application thereof
  • Fermented product of fungi strain for treating dementia and application thereof
  • Fermented product of fungi strain for treating dementia and application thereof

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Embodiment Construction

[0025] The present invention will be described in detail below with reference to the drawings and specific embodiments.

[0026] The fermentation product of the present invention is applied to a fungal strain for the treatment of dementia. The strain is obtained from the endophytic fungi of the wild Huperzia serrata (Huperzia serrata, Huperzia), and belongs to Fusarium oxysporum (Fusarium oxysporum). ) A strain of NSG-1, which is genetically stable after 20 generations in the laboratory, and its amino sequence is shown in SEQ ID NO:1.

[0027] This strain has been preserved in the China Common Microbial Strain Collection, the preservation unit designated by the State Intellectual Property Office.

[0028] (1) The fermentation product of the present invention is applied to the isolation method of fungal strains for the treatment of dementia as follows:

[0029] After washing the fresh Huperzia serrata plant with tap water, disinfect the surface with 75% alcohol for 30 seconds, rinse wi...

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Abstract

The invention discloses a fermented product of a fungi strain for treating dementia. The fungi strain is separated from endophytic fungi of Huperzia serrata and belongs to fusarium oxysporum NSG-1 strain. After the passage of 20 generations in laboratory, the fungi strain has genetic stability. The amino sequence of the fungi strain is as shown in SEQ ID NO:1. The fungi strain provided by the invention is used as a biologic strain for treating vascular dementia and senile dementia; the excellent high-efficiency expression gene for generating huperzine a is transferred into the strains in other modes; more excellent characteristics can be acquired through gene modification; besides, further optimization for the bacterial strain can be achieved through mutation breeding; the research on the fungi strain has huge significance in biosynthesis industrial production of huperzine a, plant resource protection, settlement for the clinic first-line pharmacy requirement and reduction of medical expense for treating vascular dementia and senile dementia patients.

Description

Technical field [0001] The invention belongs to the technical field of pharmaceutical microorganisms, and specifically relates to a fungal strain used for fermented products to treat dementia. The invention also relates to the application of the fungal strain. Background technique [0002] Alzheimer's disease, also known as Alzheimer's disease (AD) is a neuronal degenerative disease characterized by progressive dementia, mainly manifested as progressive cognitive dysfunction, personality and behavior changes, and memory decline Etc., leading to the death of the patient within 7-10 years after the illness. According to estimates by the International Alzheimer's Association, there were approximately 36 million dementia patients worldwide in 2010, and it is estimated that by 2050, the number of AD patients will reach 115 million. Vascular dementia (Vasculardementia, VD) is an acquired intellectual impairment syndrome caused by brain dysfunction caused by various cerebrovascular dis...

Claims

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Application Information

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IPC IPC(8): C12N1/14A61K36/062A61P25/28C12R1/77
CPCA61K36/062C12R2001/77C12N1/145
Inventor 韩文霞韩忠文李伟泽贾敏孙静贾妙杨梅周永强
Owner 陕西仁达康健医药生物科技有限公司
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