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Application of polaprezinc in preparing medicine for eradicating helicobacter pylori

A technology of Helicobacter pylori and polysulfuric acid, applied in the field of medicine, can solve the problems such as the use of Helicobacter pylori of polysaccharide is not disclosed.

Active Publication Date: 2017-03-22
吉林省博大伟业制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the prior art does not disclose the use of polyprezinc in inhibiting and eradicating Helicobacter pylori

Method used

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  • Application of polaprezinc in preparing medicine for eradicating helicobacter pylori
  • Application of polaprezinc in preparing medicine for eradicating helicobacter pylori
  • Application of polaprezinc in preparing medicine for eradicating helicobacter pylori

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A tablet, the weight of each ingredient needed to prepare 100 tablets is as follows:

[0029]

[0030]

Embodiment 2

[0032] A tablet, the weight of each ingredient needed to prepare 100 tablets is as follows:

[0033]

[0034] The preparation method of described tablet comprises the steps:

[0035] S1. Dissolving pullulan and hydroxyethyl methylcellulose in distilled water with 8 times the mass to prepare a mixed solution;

[0036] S2. Mix polyprezinc, pregelatinized starch and polymethacrylic acid resin evenly and mix them with the mixed solution evenly, then granulate, dry, and granulate to make drug granules;

[0037] S4. Add the drug granules, lactitol, and potassium sodium tartrate into a mixer and mix for 10 minutes, then place them in a tablet machine and compress to form tablets.

Embodiment 3

[0039] A tablet, the weight of each ingredient needed to prepare 100 tablets is as follows:

[0040]

[0041]

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PUM

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Abstract

The invention provides application of polaprezinc in preparing medicine for eradicating helicobacter pylori. Clinical tests prove that polaprezinc has high helicobacter pylori resisting activity and can effectively inhibit the activity of helicobacter pylori, the bactericidal efficacy of polaprezinc and medicine concentration are in positive correlation, and polaprezinc can be used for preparing related medicines for treating gastritis, gastric ulcer, gastric cancer, dodecadactylitis, duodenal ulcer, duodenal cancer and other diseases closely related to helicobacter pylori.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of polyprezinc in the preparation of medicines for eradicating Helicobacter pylori. Background technique [0002] Helicobacter pylori is a Gram-negative bacterium with unipolar, multi-flagellate, blunt-rounded, and spiral-shaped curved ends. It usually parasitizes in the mucus layer of human gastric pits and relies on the ammonia produced by its urease decomposition to neutralize gastric acid. , thereby colonizing the stomach. Helicobacter pylori secretes two toxins, CagA and VacA, among which CagA can activate the protein NFAT related to cell proliferation, promote abnormal cell proliferation, and cause a series of inflammatory reactions. It is also closely related to the occurrence of gastric cancer. At present, international standard triple therapy is commonly used clinically to treat Helicobacter pylori infection, that is, to combine bismuth, me...

Claims

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Application Information

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IPC IPC(8): A61K31/555A61K9/20A61K47/36A61K47/38A61K47/32A61K47/12A61K47/22A61K47/26A61K47/14A61P31/04A61P1/04A61P35/00A61P1/00
CPCA61K9/2013A61K9/2018A61K9/2027A61K9/205A61K9/2054A61K9/2059A61K31/555
Inventor 谢文博李晓冬黄晓光李明如腾楠生野
Owner 吉林省博大伟业制药有限公司
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