A kind of hemostatic spray adhesive and preparation method thereof

Abstract

The invention relates to a hemostasis spraying type adhesive and a preparation method thereof. The method comprises the following steps: preparing an adhesive solution; preparing nanometer grains; preparing an amine chitosan derivative; preparing the final adhesive. The adhesive prepared according to the method has the advantages that the gelation time required by adhesion is short, the mechanical strength is excellent, the bleeding can be quickly stopped and the adhesive also has quick and strong adhering property even under the existence of water.

Description

technical field

[0001] The invention relates to a hemostatic spray adhesive and a preparation method thereof. Background technique

[0002] In the field of clinical medicine, the hemostasis problem of large-scale bleeding or vascular bleeding in surgery has been plaguing the medical field. There is an urgent need for a material that can quickly stop bleeding and bond the wound. Conventional surgical techniques ensure strong pulling elongation, but has the disadvantages of pain and the need for stitches to be removed after surgery. On the other hand, tissue adhesives enjoy the advantages of short bonding time, simple usage, and no need for postoperative removal, however, tissue adhesives exhibit low adhesiveness, poor biocompatibility, and poor tensile strength and especially It is a problem that the adhesion decreases significantly in the presence of moisture.

[0003] The emergence of medical adhesives has changed the concept of relying only on needles and threads to sutu...

Examples

Embodiment 1

[0039] A preparation method of a hemostatic spraying adhesive, characterized in that the method comprises the following steps:

[0040] Step 1. Preparation of adhesive solution

[0041] Add phenol derivatives to medical ethanol, heat to 40°C and reflux until completely dissolved, then raise the temperature to 45°C, add a mixture of polyethylene glycol and maleic anhydride, stir for 5-8 hours, wash with saturated NaCl solution for 3-6 hours Second, stand still 30-60min, filter the supernatant of upper layer, use the light yellow transparent adhesive liquid of lower floor, the mass ratio of the derivative of described phenol, medical alcohol, Polyethylene Glycol and maleic anhydride is 3-5: 20-30:1-2:1-2;

[0042] Step 2, the preparation of nanoparticles:

[0043] Place the matrix in the first solution, pass nitrogen at the same time at 45°C, stir for 15-20min, then cool down to room temperature, add acid solution, keep the pH of the system at 5-8, preferably 5.5-6.5, stir for...

Embodiment 2

[0066] A hemostatic spray adhesive, characterized in that the compound has n-octyl α-cyanoacrylate compound and n-butyl α-cyanoacrylate, the structural formula of the n-octyl cyanoacrylate compound is shown in formula 3

[0067]

[0068] The mass ratio of the α-n-octyl cyanoacrylate compound to n-butyl α-cyanoacrylate is 4.5:5.5, and the hemostatic spray adhesive containing α-alkoxy cyanoacrylate is suitable for In the internal and external operations of the human body, it includes: general hepatobiliary, pancreas, spleen, gastrointestinal, cardiothoracic, urological, neurological, tumor, obstetrics, burns and plastic surgery, bone, oral, ENT and other operations for hemostasis, bonding, covering, Leakage plugging, hard tissue fixation, etc.

[0069] 1. Prevention and treatment of cerebrospinal fluid leakage

[0070] 1) Open craniocerebral injury:

[0071] The local galeal aponeurosis is broken, the damaged part is covered with sarcolemma, and the surrounding area is clos...

technical field

[0001] The invention relates to a hemostatic spray adhesive and a preparation method thereof. Background technique

[0002] In the field of clinical medicine, the hemostasis problem of large-scale bleeding or vascular bleeding in surgery has been plaguing the medical field. There is an urgent need for a material that can quickly stop bleeding and bond the wound. Conventional surgical techniques ensure strong pulling elongation, but has the disadvantages of pain and the need for stitches to be removed after surgery. On the other hand, tissue adhesives enjoy the advantages of short bonding time, simple usage, and no need for postoperative removal, however, tissue adhesives exhibit low adhesiveness, poor biocompatibility, and poor tensile strength and especially It is a problem that the adhesion decreases significantly in the presence of moisture.

[0003] The emergence of medical adhesives has changed the concept of relying only on needles and threads to sutu...

Examples

Embodiment 1

[0039] A preparation method of a hemostatic spraying adhesive, characterized in that the method comprises the following steps:

[0040] Step 1. Preparation of adhesive solution

[0041] Add phenol derivatives to medical ethanol, heat to 40°C and reflux until completely dissolved, then raise the temperature to 45°C, add a mixture of polyethylene glycol and maleic anhydride, stir for 5-8 hours, wash with saturated NaCl solution for 3-6 hours Second, stand still 30-60min, filter the supernatant of upper layer, use the light yellow transparent adhesive liquid of lower floor, the mass ratio of the derivative of described phenol, medical alcohol, Polyethylene Glycol and maleic anhydride is 3-5: 20-30:1-2:1-2;

[0042] Step 2, the preparation of nanoparticles:

[0043] Place the matrix in the first solution, pass nitrogen at the same time at 45°C, stir for 15-20min, then cool down to room temperature, add acid solution, keep the pH of the system at 5-8, preferably 5.5-6.5, stir for...

Embodiment 2

[0066] A hemostatic spray adhesive, characterized in that the compound has n-octyl α-cyanoacrylate compound and n-butyl α-cyanoacrylate, the structural formula of the n-octyl cyanoacrylate compound is shown in formula 3

[0067]

[0068] The mass ratio of the α-n-octyl cyanoacrylate compound to n-butyl α-cyanoacrylate is 4.5:5.5, and the hemostatic spray adhesive containing α-alkoxy cyanoacrylate is suitable for In the internal and external operations of the human body, it includes: general hepatobiliary, pancreas, spleen, gastrointestinal, cardiothoracic, urological, neurological, tumor, obstetrics, burns and plastic surgery, bone, oral, ENT and other operations for hemostasis, bonding, covering, Leakage plugging, hard tissue fixation, etc.

[0069] 1. Prevention and treatment of cerebrospinal fluid leakage

[0070] 1) Open craniocerebral injury:

[0071] The local galeal aponeurosis is broken, the damaged part is covered with sarcolemma, and the surrounding area is clos...

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