Tissue repair growth factor sustained-release material, preparation method and application

Abstract

The invention relates to an anti-inflammatory repair growth factor sustained-release material, a preparation method and an application. The anti-inflammatory tissue repair growth factor sustained-release material consists of platelet-rich fibrin and aspirin; and the preparation method comprises the following steps: S1, preparing aspirin complex liquid; S2, collecting venous blood; and S3, mixing the aspirin complex liquid with the venous blood, and conducting centrifuging, so as to obtain a jelly substance in an intermediate layer, namely the anti-inflammatory tissue repair growth factor sustained-release material which is a compound of the platelet-rich fibrin and the aspirin. The anti-inflammatory tissue repair growth factor sustained-release material provided by the invention is mainly applied to periodontal guided tissue regeneration or bone tissue regeneration. According to the anti-inflammatory tissue repair growth factor sustained-release material and the preparation method provided by the invention, tissue regeneration can be effectively promoted, local immunity and stem cell function can be regulated, inflammatory response can be relieved and a regeneration effect can be enhanced.

Description

technical field [0001] The invention relates to the technical field of tissue repair, in particular to an anti-inflammatory tissue repair growth factor slow-release material, a preparation method and an application. Background technique [0002] In the existing periodontal guided tissue regeneration surgery, platelet-rich fibrin is often used as a slow-release material for growth factors to promote periodontal tissue regeneration. [0003] Platelet-rich fibrin (PRF) is a second-generation platelet concentrate that includes platelets, growth factors, leukocyte cytokines, and fibrin membranes. Platelet fibrin has the ability to promote fibroblast proliferation and increased collagen synthesis. [0004] Platelet fibrin has been widely used for soft and hard tissue repair and regeneration after various periodontal surgical procedures. However, in the initial stage of bone defect repair, the host's inflammatory response plays an important role, tissue repair is inseparable from...

AI Technical Summary

Problems solved by technology

However, in the initial stage of bone defect repair, the host's inflammatory response plays an important role, tissue repair is inseparable from inflammatory response, and excessive inflammatory response will reduce the ability of bone repair

Although some immune cells may be gathered during the preparation of platelet fibrin, it is far from the anti-inflammatory effect in the early stage of tissue regeneration