On-line detection device of particle multiple characters in fluidized bed granulation process

Abstract

The invention discloses an on-line detection device of particle multiple characters in fluidized bed granulation process. The on-line detection device is arranged outside a fluidized bed reaction chamber, and is provided with a sealed shell, a sample collecting mechanism used for sampling from the reaction chamber, a visual detection unit which is arranged outside the sealed shell and is used for shooting the falling process of an obtained sample outside the sealed shell, a water detection unit, and a density detection unit used for detecting particle density; the visual detection unit comprises a camera and a measuring cylinder; the measuring cylinder is used for receiving samples falling from the sample collecting mechanism; the camera is used for shooting the process of the samples fall into the measuring cylinder, overflow of the samples out from the measuring cylinder, and sample accumulation on the top of the measuring cylinder; and an image processing system is used for obtaining particle size information from sample falling images and obtaining the angle of repose from sample accumulating images. The on-line detection device can be used for on-line detection of particle size, particle size distribution, water content, the angle of repose, bulk density, tap density, void ratio, and Hausner ratio of particles in fluidized bed granulation process.

Description

technical field [0001] The invention relates to an on-line detection device for particle multi-properties (particle size, particle size distribution, moisture, angle of repose, bulk density, tap density, void ratio, Hausner ratio) used in the fluidized bed granulation process. Background technique [0002] Fluidized bed spray granulation is to complete the traditional mixing, drying, granulation and coating in the same closed instrument at one time, and realize one-step granulation. Compared with other methods, it has the advantages of simple process, short operation time and low labor intensity. Advantages, in the pharmaceutical industry, one-step fluidized bed granulation technology has been widely used at home and abroad. [0003] For the product quality that fluidized bed makes, it is the focus that people pay close attention to all the time. At present, the quality inspection method for the granules produced in the fluidized bed is to take samples of the final product ...

AI Technical Summary

Problems solved by technology

The existing detection method has simple equipment and low cost, but the operation is cumbersome. The properties of the particles need to be measured separately by multiple different instruments, and the properties of the particles are easy to change during the transfer process. The degree will also affect the measurement results; at the same time, this method is an offline detection method, which has hysteresis and cannot meet the requirements of real-time on-line monitoring of industrial production

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