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Vitamin B2 for gestational diabetes

A technology for gestational diabetes and vitamins, applied in the field of nutritional compositions for mothers, capable of solving problems such as impaired glucose tolerance and increased risk

Active Publication Date: 2017-04-19
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, offspring of mothers with GDM are at increased risk of developing impaired glucose tolerance and / or overweight / obesity and related metabolic disorders such as type 2 diabetes and obesity

Method used

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  • Vitamin B2 for gestational diabetes
  • Vitamin B2 for gestational diabetes
  • Vitamin B2 for gestational diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0163] Contains with inositol, vitamins B6, B12 and D and Lactobacillus rhamnosus GG 1 Bifidobacterium lactis BB12 2 Exemplary compositions of combined vitamin B2 are set forth in Table 1.

[0164] The compositions in Table 1 are used in a nutritional supplement in powder form intended to be sprayed onto food.

[0165] Table 1: Composition of Example 1

[0166]

[0167]

[0168] 1) The strain deposited under the name CGMCC 1.3724

[0169] 2) The strain deposited under the name CNCM I-3446

[0170] The composition may be provided as a kit containing the probiotic powder in one sachet and all other ingredients in a second sachet.

Embodiment 2

[0172] A powdered milk beverage for pregnant women to be reconstituted in water is provided, consisting of 30 g of milk powder per serving mixed with the ingredients listed in Table 1 in half the amount mentioned in Table 1. The composition is administered to the pregnant woman twice daily during at least the last trimester of pregnancy.

Embodiment 3

[0174] The effect of vitamin B2 on glucose uptake in L6 differentiated muscle cells was measured after short-term (2 hours) and long-term (24 hours) culture.

[0175] Component G refers to vitamin B2, component k refers to 1,25-dihydroxyvitamin D3, and component J refers to zinc chloride.

[0176] Component G was tested at 1 [mu]M. Component K was tested at 10 nM and component J at 20 μM.

[0177] On the day of the experiment, components were diluted in serum-free medium (DMEM) containing 5.5 mM D-glucose to achieve final test concentrations and 0.1% DMSO.

[0178] L6 myoblasts were maintained in growth medium or DMEM 25 mM glucose supplemented with 10% fetal bovine serum (FBS), 100 U / ml penicillin and 100 μg / ml streptomycin. For glucose uptake studies, cells were cultured in 24-well plates at a density of 1000-1500 cells / well in 0.5 mL of growth medium. Five days after plating, in DMEM 25 mM glucose containing 2% FBS, 100 U / ml penicillin and 100 μg / ml streptomycin at 37 °C...

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Abstract

The present invention relates to a maternal nutrition composition comprising myo-inositol and vitamin B2. Such a composition has been specifically designed to provide optimized nutrition to a woman desiring to get pregnant, to a pregnant woman and / or to a lactating woman. The present invention also relates to vitamin B2 for use to treat or prevent gestational diabetes mellitus and a condition associated therewith in a pregnant subject or its offspring, wherein said vitamin B2 is administered to said subject before and / or during pregnancy and / or during lactation.

Description

technical field [0001] The present invention relates to a maternal nutritional composition comprising inositol and vitamin B2. This composition is specifically designed to provide optimal nutrition to women desiring pregnancy, pregnant and / or nursing. The present invention also relates to the use of vitamin B2 or compositions comprising vitamin B2 for the treatment or prevention of gestational diabetes and its related disorders in pregnant individuals and / or their offspring. Background technique [0002] Accumulating scientific evidence shows that early nutrition and other environmental factors, both prenatal and postnatal, affect the regulation of long-term health and well-being and can contribute to the risk of developing chronic disease. Several studies have shown that changes in dietary intake or manipulation of various macro- and micronutrients during the reproductive period can affect several physiological processes such as growth, metabolism, appetite, cardiovascular...

Claims

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Application Information

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IPC IPC(8): A61K31/525A61K31/047A61K35/744A61K35/745A61K35/747A61K31/4415A61K31/714A61P15/00A61P3/10A61K31/59A23L33/105A23L33/135A23L33/15
CPCA23L33/105A23L33/135A61K31/4415A61P15/00A61K31/047A61K31/525A61K31/59A61K31/714A61K35/744A61K35/745A61K35/747A23V2002/00A61K2300/00A23V2200/3204A23V2200/328A23V2250/641A23V2250/7044A23L33/15A61K31/593A61K31/7004A61P3/10
Inventor I·席尔瓦佐雷兹C·梅斯K·M·戈弗雷P·N·贝克Y·S·宗
Owner SOC DES PROD NESTLE SA
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