Cubic liquid crystalline precursor injection of oncolytic virus and preparation method thereof
An oncolytic virus, liquid crystal precursor technology, applied in the directions of liquid delivery, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. The effect of improving in vitro stability, easy availability of raw materials, and maintaining drug activity
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Embodiment 1
[0043] This example provides a cubic liquid crystal precursor injection of oncolytic virus, which is prepared from the following raw materials:
[0044]
[0045] The preparation method of the cubic liquid crystal precursor injection of the oncolytic virus is as follows:
[0046] Weigh 0.500g GMO and 0.035g F127 and eutectic at 37°C to obtain mixture I; weigh 0.1ml HSV-1 and add it to 0.365ml dispersion medium, shake well to obtain mixture II (0.47g); vortex Slowly add the mixture II to the mixture I dropwise, and vortex evenly to obtain the cubic liquid crystal precursor injection of the oncolytic virus. Seal and store at -4°C.
Embodiment 2
[0048] This example provides a cubic liquid crystal precursor injection of oncolytic virus, which is prepared from the following raw materials:
[0049]
[0050]
[0051] The preparation method of the cubic liquid crystal precursor injection of the oncolytic virus is as follows:
[0052] Weigh 0.550g GMO and 0.025g F127 and eutectically melt at 37°C to obtain mixture I; weigh 0.1ml HSV-1 and add it to 0.325ml dispersion medium, shake well to obtain mixture II (0.43g); vortex Slowly add the mixture II to the mixture I dropwise, and vortex evenly to obtain the cubic liquid crystal precursor injection of the oncolytic virus. Seal and store at -4°C.
Embodiment 3
[0054] This example provides a cubic liquid crystal precursor injection of oncolytic virus, which is prepared from the following raw materials:
[0055]
[0056] The preparation method of the cubic liquid crystal precursor injection of the oncolytic virus is as follows:
[0057] Weigh 0.650g GMO and 0.015g F127 and eutectic at 37°C to obtain mixture I; weigh 0.1ml HSV-1 and add it to 0.235ml dispersion medium, shake well to obtain mixture II (0.34g); vortex Slowly add the mixture II to the mixture I dropwise, and vortex evenly to obtain the cubic liquid crystal precursor injection of the oncolytic virus. Seal and store at -4°C.
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Abstract
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