Dendronized alcoxyl ether polymer, modified gold nano microspheres thereof and preparation method thereof

A technology of alkoxy ether and polymer, which is applied in the field of alkoxy ether dendritic polymers, can solve the problems of slow temperature-sensitive recovery process, poor biocompatibility, and inability to directly observe, etc., to achieve good biocompatibility Effects of high resistance, excellent temperature-sensitive properties, excellent reversible temperature-sensitive shrinkage and swelling behavior

Active Publication Date: 2017-05-10
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to the small size of the polymers, it is impossible to observe directly, and most of them conta...

Method used

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  • Dendronized alcoxyl ether polymer, modified gold nano microspheres thereof and preparation method thereof
  • Dendronized alcoxyl ether polymer, modified gold nano microspheres thereof and preparation method thereof
  • Dendronized alcoxyl ether polymer, modified gold nano microspheres thereof and preparation method thereof

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Embodiment 1

[0030] The invention relates to the preparation of temperature-sensitive dendritic gold nanometer microspheres.

[0031] 1. Synthesis of dendritic alkoxy ether monomers

[0032] A solution of acryloyl chloride (2.50 g) in dry DCM (10 mL) was added dropwise to a solution of compound G1-OH (10.20 g), TEA (8.10 g) and DMAP (0.39 g) in dry DCM (100 mL) solution, keep the temperature of the ice bath at 0 during the dropwise addition o C. Remove the ice bath after half an hour, continue to stir at room temperature for 4 h, and then drop methanol to terminate the reaction. The reaction solution was sequentially washed with saturated NaHCO 3 solution and saturated NaCl solution, and after separation, use anhydrous MgSO 4 The organic phase is dried and filtered. Purify by silica gel column chromatography to obtain dendritic alkoxyether monomer MG1 (6.80 g), with a yield of 81%.

[0033] 2. Synthesis of temperature-sensitive dendritic alkoxyether polymers

[0034]Add dendritic alk...

Embodiment 2

[0037] Embodiment 2: In this embodiment, the prepared aqueous solution of 0.005 wt% gold nanoparticles was tested by transmission electron microscope and atomic force microscope. see image 3 . It shows that the prepared gold nanoparticles have good dispersion.

Embodiment 3

[0038] Example 3: In this example, the prepared 0.005 wt% aqueous solution of temperature-sensitive dendritic gold nanospheres was tested by transmission electron microscope and atomic force microscope. see Figure 4 . It shows that the temperature-sensitive dendritic gold nanospheres have been successfully prepared.

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Abstract

The invention relates to dendronized alcoxyl ether polymer, modified gold nano microspheres thereof and a preparation method thereof. The gold nano microspheres are prepared by enabling the dendronized alcoxyl ether polymer with trithioester at the terminal to act with the surfaces of gold nanoparticles to form gold-sulfur bonds. The temperature-sensitive dendronized gold nano microspheres have the advantages of nanoscale and good monodispersity, a single microsphere can show temperature sensitive behaviors like quick dewatering collapse along with temperature rise, size of the microspheres becomes small, and the process is reversible. The surfaces of the temperature-sensitive dendronized gold nano microspheres contain large-size dendronized alcoxyl ether polymer, so that the microspheres have high capacity of loading micromolecular compounds and good biocompatibility, thereby having potential application value in the fields of biomedical materials, intelligent photoelectric materials and nano containers.

Description

technical field [0001] The invention relates to an alkoxy ether branched polymer with temperature-sensitive behavior, its modified gold nano-microsphere and a preparation method thereof. Background technique [0002] Gold nanoparticles have obvious surface effects, volume effects, quantum effects, small size effects and macroscopic quantum tunneling effects. Their optical, electronic, sensing and biochemical properties have become research hotspots. and other technical fields have broad application prospects. In particular, gold nanoparticles have special stability due to their weakly charged ligand binding layer, and the surface is easy to be improved, and can generate non-covalent electrostatic bonds with amino groups, sulfur groups, proteins (certain antibodies, antigens), etc. Adsorption, the complexes labeled with gold nanoparticles were obtained, and still have similar spectral properties to gold nanoparticles, which provides a basis for its application in biological ...

Claims

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Application Information

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IPC IPC(8): C08F120/30C08F8/42C08G83/00
Inventor 李文熊初平董庆豪刘洁陈艳琼饶玉妍刘坤张阿方
Owner SHANGHAI UNIV
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