Multi-site detection area, microelectrode array and preparation method thereof
A technology of microelectrode array and detection electrode, which is applied in the field of biosensors, can solve the problems that the signal is easily overwhelmed by interference, the increase of impedance and thermal noise, and the release of neurotransmitters cannot be accurately measured, so as to improve the electrocatalysis of transmitters. ability, the effect of reducing electrode impedance
Active Publication Date: 2019-12-03
INST OF ELECTRONICS CHINESE ACAD OF SCI
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[0003] In the test of neurotransmitter electrochemical signals, since the detection is carried out outside the cell, the measured signal (amplitude of the picoampere level) is easily overwhelmed by interference due to the limitation of the structure of the detection device and the white noise of the objective environment. The release amount (nanomolar to micromolar level) cannot be accurately measured
Existing microelectrode arrays have problems such as increased impedance and thermal noise due to the small size of the electrodes
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[0019] Certain embodiments of the invention will be described more fully hereinafter with reference to the accompanying drawings, in which some, but not all embodiments are shown. Indeed, various embodiments of the invention may be embodied in many different forms and should not be construed as limited to these set forth embodiments; rather, these embodiments are provided so that this invention will satisfy applicable legal requirements.
[0020] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with specific embodiments and with reference to the accompanying drawings.
[0021] The present invention obtains a planar electrode array chip suitable for multi-active-site neurotransmitter detection by modifying the surface of the planar microelectrode array with nanocomposite materials, which overcomes the difficulty of single-point detection of cell secretio...
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Abstract
The invention provides a multi-site detection region, a microelectrode array and a preparation method thereof, which are suitable for detection of multi-active-site neurotransmitter, wherein the multi-site detection region comprises a detection electrode body and a nano composite film layer arranged on the detection electrode body; a planary micro-electrode array adopting the multi-site detection region improves neurotransmitter electro-catalysis capacity, reduces electrode impedance and thermal noise, and the like.
Description
technical field [0001] The invention relates to the field of biosensors, in particular to a multi-site inspection area, a microelectrode array and a preparation method thereof, which are used for the detection of multi-active site neurotransmitters. Background technique [0002] The brain is a neural network composed of more than 140 billion neuron cells, which play a role in sensing the external world and coordinating the activities of body organs. The dendrites and axons of neurons can only transmit information about neurobehavior with matching receptors. Neurotransmitter is an important link between neurons, and plays an extremely important role in the central nervous system, peripheral autonomic nervous system and hormone-mediated endocrine and exocrine activities. It is closely related to a variety of functional diseases and diseases. For example, glutamate is a neurotransmitter related to stroke. After brain ischemia and hypoxia, glutamate is excessively released, caus...
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IPC IPC(8): G01N27/327
CPCG01N27/3278
Inventor 王力蔡新霞罗金平宋轶琳徐辉任王杨
Owner INST OF ELECTRONICS CHINESE ACAD OF SCI