Application of clerodendranthus spicatus diterpenoid ketone B to preparation of medicines for treating gout

A diterpene ketone and drug technology, applied in the application field of kidney tea diterpene ketone B in the preparation of medicines for treating gout, can solve the problems of weak kidney protection function, and achieve the effect of good curative effect and low dose

Inactive Publication Date: 2017-05-17
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Allopurinol is the representative of this type of drug, and it has always been the first-line anti-gout drug in clinical practice. Although the effect of lowering uric acid is significant, the protective function of the kidney is very weak

Method used

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  • Application of clerodendranthus spicatus diterpenoid ketone B to preparation of medicines for treating gout
  • Application of clerodendranthus spicatus diterpenoid ketone B to preparation of medicines for treating gout

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0013] Experimental example 1: Kidney tea diterpene ketone B anti-acute gout inflammation experiment:

[0014] 1: method

[0015] ① Solution preparation

[0016] Boil 5g of uric acid with 1000ml of distilled water, add 5% NaOH solution to adjust the pH to 7.4, stir, cool and crystallize to make sodium urate crystals (MSU). Autoclave 10 mg of the prepared MSU, add 10 ml of serum-free DMEM culture solution, and grind to prepare a 1 mg / ml DMEM solution. During the experiment, this solution was added with DMEM culture medium to make MSU solutions with different concentrations of DMEM.

[0017] Kidney tea diterpene ketone B 2.5mg, dissolved in ethanol, the final concentration <0.02%, plus serum-free DMEM culture medium, prepared to a concentration of 2.5ug / ml, 25ug / ml, 250ug / ml.

[0018] Positive drug indomethacin 2.0mg, the method is the same as kidney tea diterpene ketone B, the preparation concentration is 20ug / ml.

[0019] ② In vitro culture of vascular endothelial cells

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Abstract

The invention relates to application of clerodendranthus spicatus diterpenoid ketone B to preparation of medicines for treating gout. The clerodendranthus spicatus diterpenoid ketone B has the characteristics of low dosage and excellent treatment effect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of kidney tea diterpene ketone B in the preparation of medicines for treating gout. Background technique [0002] Hyperuricemia and gout have become one of the civilized diseases of modern life. It is a kind of high uric acid in the blood due to the increase of purine synthesis and metabolism in the body, excessive production of uric acid or poor excretion of uric acid. Hyperuricemia is only a disease of gout A biomarker of . The clinical manifestations of gout are often divided into acute phase, intermittent phase, chronic phase and renal disease, mainly manifested as gouty arthritis and gouty nephropathy. The occurrence of renal lesions is the result of long-term development of hyperuricemia. Almost all patients with hyperuricemia have renal pathological damage to varying degrees, and about 1 / 3 of patients develop renal symptoms during the course of the diseas...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61P19/06
CPCA61K31/122
Inventor 郭尔楚蒋敏捷陈文雅
Owner GUANGXI UNIV OF CHINESE MEDICINE
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