Composite preparation, containing novel 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivative and another active ingredient, for preventing or treating metabolic diseases

A metabolic disease, benzyloxy technology, applied in the field of pharmaceutical compositions for the prevention or treatment of metabolic diseases, can solve problems such as low therapeutic responsiveness, and achieve excellent blood sugar lowering effect
CN106715409AActive Publication Date: 2017-05-24HYUNDAI PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HYUNDAI PHARMA
Publication Date
2017-05-24

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Abstract

The present invention relates to a pharmaceutical composition for preventing or treating metabolic diseases, in which a novel 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivative and at least another active ingredient, which is selected from the group consisting of dipeptidyl peptidase-4 (DPPIV) inhibitor-based, sulfonylurea-based, thiazolidinedione (TZD)-based, biguanide-based, and sodium / glucose cotransporter 2 (SGLT2) inhibitor-based drugs, may be administered in combination or in the form of a composite preparation. The use of the composition of the present invention can provide a remarkably excellent blood sugar reducing effect in various animal diabetic disease models, and the composition of the present invention can be favorably used as a pharmaceutical composition for preventing or treating metabolic diseases, such as obesity, diabetes type I, diabetes type II, glucose intolerance symptoms, insulin resistance symptoms, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, dyslipidemia, and syndrome X.
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Description

technical field

[0001] This patent application claims the priority right of the Korean application right No. 10-2014-0141216 filed with the Korean Patent Office on October 17, 2014, and the disclosure of the patent application is incorporated herein by reference.

[0002] The present invention relates to novel 3-(4-(benzyloxy)phenyl)-4-hexenoic acid derivatives which can be obtained by selecting novel 3-(4-(benzyloxy)phenyl)-4-hexenoic acid derivatives and consisting of dipeptidyl peptidase 4 (Dipeptidyl peptidas e-4, DPPIV) inhibitors, sulfonic acid Select at least one other drug from the group consisting of Sulfonylurea, Thiazolidinediones, TZD, Biguanide and sodium / glucose cotransporter 2 inhibitors A pharmaceutical composition for preventing or treating metabolic diseases with active ingredients administered in combination or in the form of a compound. Background technique

[0003] Diabetes, as a disease that affects more than 100 million people worldwide, is continuous...

Claims

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