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Application of lipoic acid as antioxidant in ethyl polyenoate preparation or pupal fat alpha-ethyl linolenate preparation

A technology of ethyl polyenoate and ethyl linolenic acid is applied in the application field of lipoic acid as antioxidant in ethyl polyenoate preparation or pupa oil ethyl alpha-linolenic acid preparation, and can solve the problem of high degree of unsaturation. , Antioxidant effect is not ideal, etc.

Inactive Publication Date: 2017-05-31
北京百慧生化制药有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high degree of unsaturation of the two drugs, the antioxidant effect of TBHQ in the two drugs is not ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 lipoic acid and vitamin E are compared as the effect in the antioxidant substance of polyenoic acid ethyl ester and pupal oil α-linolenic acid ethyl ester

[0020] Test method: Place 1kg each of polyenoic acid ethyl ester and pupa oil α-linolenic acid ethyl ester in a general open container respectively, add 0.5% lipoic acid or vitamin E to the drug to be tested, mix well, Make it contact with the air, and detect the change of peroxide value after half an hour.

[0021] Experimental results: the polyenoic acid ethyl ester with vitamin E was opened in the air. After half an hour, the peroxygen value had exceeded the standard (that is, the consumption of 0.01mol / L sodium thiosulfate titration solution > 15.0mL), and the lipoic acid was added Ethyl polyenoate, the opening is placed in the air for half an hour, and the peroxide value has no obvious change.

Embodiment 2

[0022] Example 2 Lipoic acid and vitamin E as the effect comparison in the antioxidant substances of polyenoic acid ethyl ester and pupa oil α-linolenic acid ethyl ester soft capsule

[0023] Test method: Add 1% lipoic acid or vitamin E to 1kg each of the drug to be tested, polyenoic acid ethyl ester and pupa oil α-linolenic acid ethyl ester, mix well and prepare soft capsules, store for one month under standard conditions, and test Changes in peroxide value.

[0024] Test results: After adding vitamin E ethyl polyenoate soft capsules and pupa oil α-linolenic acid ethyl ester soft capsules, after one month, the peroxide value of polyenoate ethyl increased from 3.44 to 4.10, pupa oil α- The peroxide value of ethyl linolenate increased from 1.50 to 2.05. The polyenoic acid ethyl ester with lipoic acid and pupae oil α-linolenic acid ethyl ester were sealed in soft capsules respectively. After one month, the peroxide value did not change significantly. .

[0025] From above-ment...

Embodiment 3

[0027] Get polyenoic acid ethyl ester crude drug 10kg, add the lipoic acid solid of 50g (being equivalent to 0.5% of medicinal liquid), after mixing, expose to the air and place after 30 minutes, the peroxide value increases by 0.3.

[0028] The polyenoic acid ethyl ester medical solution added with the lipoic acid is immediately sealed and packaged in a soft capsule, and stored for one month under standard storage conditions, the peroxide value of the medicinal solution in the capsule has no obvious change.

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Abstract

The invention provides an application of lipoic acid as an ioxidant in ethyl polyenoate preparation or pupal fat alpha-ethyl linolenate preparation. Ehyl polyenoate and pupal fat alpha-ethyl linolenate drugs are both polyunsaturated fatty acid drugs. With a plurality of unsaturated double bonds, the ethyl polyenoate and pupal fat alpha-ethyl linolenate are easily oxidized by contact with oxygen in air. After peroxidation, the curative effect is seriously influenced, and side effects may be generated. Through study and experiment, lipoic acid realizes remarkably effective oxidation resistance against ethyl polyenoate and pupal fat alpha-ethyl linolenate drugs; by replacing vitamin E with lipoic acid, an effective anti-oxidation effect on the two drugs is realized; and unprecedented technical progress and innovation are realized for existing anti-oxidation way of the two drugs.

Description

technical field [0001] The invention relates to the application of lipoic acid as an antioxidant in polyenoic acid ethyl ester preparations or pupa oil alpha-linolenic acid ethyl ester preparations. Background technique [0002] Polyenoic acid ethyl ester and pupae oil α-linolenic acid ethyl ester are both polyunsaturated fatty acid drugs, and polyenoic acid ethyl ester is composed of EPA-E (eicosapentaenoic acid ethyl ester) and DHA-E (docosahexaenoic acid ethyl ester). They have five and six unsaturated double bonds, pupal oil α-linolenic acid ethyl ester is composed of α-linolenic acid ethyl ester, which has three unsaturated double bonds. Due to the relatively high unsaturated double bonds in the components of these two medicines, their double bonds are easily oxidized by oxygen when they meet the oxygen in the air, so that the double bonds are destroyed, which not only loses the efficacy of the medicine, but also produces harmful effects. side effect. Enhancing their...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/20A61K31/231A61K31/232
CPCA61K47/20A61K31/231A61K31/232
Inventor 刘荣逵
Owner 北京百慧生化制药有限责任公司
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