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Quality standard of compound amoxicillin micro-capsule dry suspension

A technology of amoxicillin and dry suspension is applied in the field of quality standards of compound amoxicillin microcapsule dry suspension, and can solve the quality standard, collection and collection of compound amoxicillin microcapsule dry suspension without veterinary drugs The quality standard is simple, and it is difficult to effectively control the quality of the finished product, so as to achieve the effect of good reproducibility, improved quality standard and strong specificity

Inactive Publication Date: 2017-05-31
金河牧星(重庆)生物科技有限公司
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Problems solved by technology

[0020] At present, the quality standards of amoxicillin preparations are included in the 2015 edition of "Chinese Pharmacopoeia" Part II, but there is no quality standard for compound amoxicillin microcapsule dry suspension for veterinary drugs, and the 2015 edition of "Chinese Pharmacopoeia" contains quality standards Simple, difficult to effectively control the quality of finished products

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Embodiment Construction

[0068] The claims of the present invention will be further described in detail below in combination with specific embodiments, and many specific details are set forth in the following description to facilitate a full understanding of the present invention.

[0069] However, the present invention can be implemented in many other ways different from those described here, and those skilled in the art can make similar improvements without departing from the connotation of the present invention, so the present invention is not limited by the specific implementations disclosed below.

[0070] The application provides a quality standard for compound amoxicillin microcapsule dry suspension, which is characterized in that it includes thin layer identification experiment, content determination experiment, accelerated stability experiment, pharmacokinetic experiment and pharmacodynamics research experiment.

[0071] Amoxicillin is an oral semi-synthetic antibiotic, characterized by a wide...

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Abstract

The invention provides a quality standard of a compound amoxicillin micro-capsule dry suspension. The quality standard comprises a thin layer identification experiment, a content determination experiment, an acceleration stability experiment, a pharmacokinetics experiment and a pharmacodynamics study experiment. Compared with the prior art, the compound amoxicillin micro-capsule dry suspension provided by the invention has the advantages that various combined experiment methods are used; the compound amoxicillin micro-capsule dry suspension is investigated in various aspects of qualitation, quantification, stability, pharmacokinetics and medicine effect of substances; the quality standard of the compound amoxicillin micro-capsule dry suspension is improved; the strong specificity and the good reproducibility are realized; the effective control of the finished product quality of the compound amoxicillin micro-capsule dry suspension is facilitated.

Description

technical field [0001] The invention relates to the related technical field of veterinary medicine, more specifically, relates to the quality standard of compound amoxicillin microcapsule dry suspension. Background technique [0002] Amoxicillin is an oral semi-synthetic antibiotic, characterized by a wide antibacterial spectrum, a white powder, stable under acidic conditions, and a gastrointestinal absorption rate of 90%; it has the characteristics of strong bactericidal power and extremely low toxicity. It is suitable for mild to moderate infections and is currently widely used in bacterial infections of livestock and poultry. However, amoxicillin is slightly soluble in water, so the standard concentration of amoxicillin soluble powder on the market is generally not higher than 10%, and because of its short half-life of about 61.3 minutes, it needs to be administered 4-5 times a day. [0003] Pharmacological effects of amoxicillin: [0004] Amoxicillin is a semi-syntheti...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/15
CPCG01N33/15
Inventor 何丽花周建唐文龙秦斌
Owner 金河牧星(重庆)生物科技有限公司
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