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Application of MED6 genes serving as acute myocardial infarction risk prediction marker

A technology for acute myocardial infarction and risk prediction, applied in the fields of gene diagnosis and biomedicine

Inactive Publication Date: 2017-06-06
JILIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The mediator complex subunit 6 protein encoded by the MED6 gene is an important part of MED and is involved in the transcriptional regulation of almost all RNA polymerase Ⅱ-related genes. There is no report on the relationship between MED6 and myocardial infarction in existing studies

Method used

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  • Application of MED6 genes serving as acute myocardial infarction risk prediction marker
  • Application of MED6 genes serving as acute myocardial infarction risk prediction marker
  • Application of MED6 genes serving as acute myocardial infarction risk prediction marker

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Embodiment Construction

[0022] The present invention will be further elaborated in conjunction with examples and specific examples, which are only used to explain the present invention, and cannot be construed as limiting the present invention. Those skilled in the art can understand that various changes, modifications, substitutions and modifications can be made to these embodiments without departing from the principle and purpose of the present invention.

[0023] The present invention mainly uses fluorescent quantitative PCR to screen out genes related to acute myocardial infarction, and combines molecular biology experiments and clinical case correlation analysis. It is a marker for the diagnosis and treatment of acute myocardial infarction.

[0024] collection of cases

[0025] According to the global unified definition of myocardial infarction published in 2012. A total of 106 patients who were hospitalized in the Department of Cardiovascular Medicine, China-Japan Friendship Hospital of Jilin...

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Abstract

The invention provides application of MED6 genes serving as an acute myocardial infarction risk prediction marker. The MED6 genes or gene expression products are taken as a novel acute myocardial infarction risk prediction and diagnoses and treatment target. The MED6 genes and expression products thereof are used for preparing acute myocardial infarction risk prediction markers and diagnoses preparations and have important clinical application significance and development values.

Description

[0001] Technical field: [0002] The invention provides a marker for predicting and diagnosing acute myocardial infarction, and further provides MED6 gene as a marker expression product and the use of biological preparations in the preparation of drugs for predicting and diagnosing and treating acute myocardial infarction, which belongs to the field of gene diagnosis and biomedicine. [0003] Background technique: [0004] Coronary atherosclerotic heart disease (CAD for short) is the most common cardiovascular disease that endangers human health. Although through the improvement of lifestyle and the control of major risk factors such as hyperlipidemia, hypertension, diabetes, metabolic syndrome, and smoking, the mortality rate of coronary heart disease has generally shown a downward trend. However, with the growth and aging of the population, coronary heart disease is expected to remain a huge health and economic burden worldwide by 2030. Therefore, clinically effective risk p...

Claims

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Application Information

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IPC IPC(8): C12Q1/68G01N33/68
CPCC12Q1/6883C12Q2600/158G01N33/6893G01N2800/324
Inventor 孟繁波杨丽萍谭卜川刘谦张文杨玉双
Owner JILIN UNIV
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