Application of Triazole Sulfonate Compounds in Controlling Bacterial Diseases of Rice
A technology for azole sulfonate and rice diseases, which is applied in the application, animal repellent, plant growth regulator and other directions, can solve the problem of not many fungicides, difficult long-term control of fungicides, and bacteria that are prone to drug resistance, etc. problem, to achieve effective bactericidal effect, excellent effect
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preparation example Construction
[0057] According to the present invention, the triazole sulfonate compound shown in the above formula (1) can be synthesized by conventional methods in the art, preferably, the triazole sulfonate compound shown in the above formula (1) Preparation methods include:
[0058] (1) In the presence of a basic compound, the compound shown in formula (2) is etherified with the compound shown in formula (3), to obtain a compound shown in formula (4), formula (2) R 2 -OH; Formula (3)X-L 1 -NO 2 , X is halogen (preferably F); formula (4) R 2 -O-L 1 -NO 2 ;
[0059] (2) In the presence of a catalytic hydrogenation catalyst, the compound represented by the formula (4) is subjected to a catalytic hydrogenation reaction to obtain a compound represented by the formula (5), the formula (5) R 2 -O-L 1 -NH 2 ;
[0060] (3) react the compound shown in formula (5) to obtain the compound shown in formula (6), formula (6) R 2 -O-L 1 -OH;
[0061] (4) carry out esterification reaction wit...
preparation example 1
[0096] This preparation example is used to illustrate the preparation method of the triazole sulfonate compound of the present invention.
[0097] (1) Under nitrogen protection, 1.0mmol of p-fluoronitrobenzene, 1.1mmol of 2-cyanophenol and 1.5mmol of K 2 CO 3 Add to 5 mL of DMF and react in an oil bath (oil bath temperature 60°C) for 8 hours, and monitor the reaction progress by TLC. After the reaction, the system was cooled to room temperature, poured into ice water, a large amount of precipitation occurred, after standing for separation, the intermediate 2'-cyanophenoxy-4-nitrobenzene was obtained by filtration.
[0098] (2) Dissolve 5 mmol of 2'-cyanophenoxy-4-nitrobenzene in a certain amount of dichloromethane (usually 25 mL), add 10% Pd-C (the weight of adding Pd-C is 2 15% of '-cyanophenoxy-4-nitrobenzene weight), pass into H 2 , TLC monitoring reaction process, room temperature (about 25 ℃) reaction 30 minutes, after reaction finishes, filter, and filtrate is removed...
preparation example 2-51
[0102] This preparation example is used to illustrate the preparation method of the triazole sulfonate compound of the present invention.
[0103] According to the method described in Preparation Example 1, the compounds listed in Table 1 were prepared. The structural identification of these compounds is shown in Table 1, but in the preparation process, the difference from Preparation Example 1 is:
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