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Application of Psoriasin antibody and LL-37 antibody in preparing drug for preventing and treating psoriasis

A LL-37, psoriasis technology, applied in the direction of antibodies, drug combinations, antibody medical components, etc., can solve the problems of long-term recurrence rate not reduced, unbearable for patients, poor effect, etc., to inhibit the development of psoriasis , Promoting apoptosis, significant therapeutic effect

Pending Publication Date: 2017-07-14
XI AN JIAOTONG UNIV
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Problems solved by technology

At present, retinoic acid drugs are mostly used for treatment, but the effect is not good and recurrence is easy, and the side effects are also relatively large in the later stage. Although the effect of small molecule biological therapy is good, the cost is extremely high, which is unbearable for patients, and the long-term recurrence rate is not high. Therefore, the treatment of psoriasis has become the focus of research

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  • Application of Psoriasin antibody and LL-37 antibody in preparing drug for preventing and treating psoriasis
  • Application of Psoriasin antibody and LL-37 antibody in preparing drug for preventing and treating psoriasis
  • Application of Psoriasin antibody and LL-37 antibody in preparing drug for preventing and treating psoriasis

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Embodiment Construction

[0041] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0042] LL-37 and psoriasin are not only highly expressed in psoriasis, but also play an important role in the pathological manifestations of psoriasis. They are at the initial position in the pathogenesis of psoriasis. The increase of permeability, the chemotaxis, increase and aggregation of inflammatory cells, the release of inflammatory factors, the proliferation of KC and the hyperplasia of blood vessels make psoriasis no longer develop. These antibodies can inhibit the apoptosis and It plays an important role in maintaining the stability of the immune system, which can suppress hyperimmunity and autoimmunity. Therefore, using the optimal ratio of LL-37 antibody and psoriasin antibody at an appropriate concentration to treat the imiquimod mouse psoriasis model can improve erythema, scale a...

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Abstract

The invention discloses an application of a Psoriasin antibody and an LL-37 antibody in preparing a drug for preventing and treating psoriasis. In comparison to the situation that necessary cell factors and chemotactic factors in a Th cell differentiation inhibiting process are focused on to inhibit inflammation, not only is differentiation inhibition of a Th cell emphasized, but also apoptosis of activated T cells is promoted. Furthermore, by comparing and exploring the optimum rate of the two antibodies by using an external treatment imiquimod mouse model, a result verifies that the treatment effect of 5[mu]g / ml LL37 antibody and 1[mu]g / ml psoriasin antibody is relatively obvious and a relatively high PASI score is acquired.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to the application of Psoriasin antibody and LL-37 antibody in the preparation of medicines for preventing and treating psoriasis. Background technique [0002] Psoriasis is a chronic inflammatory skin disease with a high incidence rate and easy recurrence, which seriously affects the quality of life of patients. The pathological manifestations of psoriasis are excessive proliferation and abnormal differentiation of epidermal keratinocytes (KC), tortuous hyperplasia and expansion of blood vessels in the superficial dermis, and infiltration of inflammatory cells in the dermal epidermis. The main infiltrating cells are neutrophils and T lymphocytes. In the acute phase, Munro microabscesses formed by neutrophils can be seen, while the chronic phase is mainly infiltrated by T lymphocytes. At present, retinoic acid drugs are mostly used for treatment, but the effect is not good and rec...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61P17/06
CPCC07K16/18C07K16/22A61K2039/507A61K2039/57
Inventor 郑焱李昌吉杨珮雯邵永平
Owner XI AN JIAOTONG UNIV
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