Degradable blood vessel anastomat provided with drug membrane layer and preparation process of degradable blood vessel anastomat

A preparation process and stapler technology, which is applied in the field of medical devices, can solve the problems that are not conducive to the crawling, growth, and coverage of host vascular intima tissue, poor positioning of vascular staplers, and slow healing speed, etc., to achieve fast and effective Easy connection and anastomosis, fast healing effect

Inactive Publication Date: 2017-07-18
DONGGUAN EONTEC CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But also there are following problems: 1, it comprises two identical end pipes and a sleeve pipe, has the shortcoming of complex structure and troublesome operation
2. Since the vascular stapler cannot be

Method used

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  • Degradable blood vessel anastomat provided with drug membrane layer and preparation process of degradable blood vessel anastomat
  • Degradable blood vessel anastomat provided with drug membrane layer and preparation process of degradable blood vessel anastomat

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0028] Example 1:

[0029] like Figure 1 to Figure 2 As shown, a degradable vascular stapler with a drug film layer includes a sleeve 10 made of a degradable metal material; the wall of the sleeve 10 is provided with an outwardly protruding perforation structure 20 ; The inner wall of the cannula 10 is provided with a drug film layer 30, and the drug film layer is polyglycolic acid containing anticoagulant drugs.

[0030] The thickness of the drug film layer is 0.1mm. The casing is prepared by a vacuum hot extrusion process, with a wall thickness of 0.1±0.02 mm, a surface roughness of 1.6, and a cylindricity (or straightness) of 0.009. The diameter of the burr hole of the burr hole structure is 0.2 mm, and the height (hole edge) of the burr hole is 0.05 mm. The degradable metal material is Mg-Fe alloy. The outer diameter of the sleeve coincides with the inner diameter of the host blood vessel to be connected.

[0031] A preparation process of a degradable vascular staple...

Example Embodiment

[0037] Example 2:

[0038]A degradable vascular stapler with a drug film layer, including a sleeve made of degradable metal material; the tube wall of the sleeve is provided with an outwardly protruding hole structure; the sleeve of the sleeve Both the inner wall and the outer wall are provided with a drug film layer, and the drug film layer is polylactic acid containing anticoagulant drugs.

[0039] The thickness of the drug film layer is 0.2mm. The casing is prepared by a vacuum hot extrusion process, with a wall thickness of 0.1±0.02 mm, a surface roughness of 1.6, and a cylindricity (or straightness) of 0.009. The diameter of the burr hole of the burr hole structure is 0.2 mm, and the height (hole edge) of the burr hole is 0.05 mm. The degradable metal material is Mg-Zn-Fe alloy. The outer diameter of the sleeve coincides with the inner diameter of the host blood vessel to be connected.

[0040] A preparation process of a degradable vascular stapler with a drug film la...

Example Embodiment

[0046] Example 3:

[0047] A degradable vascular stapler with a drug film layer, including a sleeve made of degradable metal material; the tube wall of the sleeve is provided with an outwardly protruding hole structure; the sleeve of the sleeve A drug film layer is provided on the inner wall and / or the outer wall, and the drug film layer is a collagen film containing an anticoagulant drug or a keratin film containing an anticoagulant drug.

[0048] The thickness of the drug film layer is 0.1mm. The casing is prepared by a vacuum hot extrusion process, with a wall thickness of 0.1±0.02 mm, a surface roughness of 1.6, and a cylindricity (or straightness) of 0.009. The diameter of the burr hole of the burr hole structure is 0.2 mm, and the height (hole edge) of the burr hole is 0.05 mm. The degradable metal material is Mg-Fe alloy. The outer diameter of the sleeve coincides with the inner diameter of the host blood vessel to be connected.

[0049] A preparation process of a d...

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Abstract

The invention discloses a degradable blood vessel stapler with a drug film layer and a preparation process thereof, comprising a sleeve made of degradable metal materials; Pore ​​structure; the inner wall and/or outer wall of the casing is provided with a drug film layer, and the drug film layer is a polymer film containing a drug component or a biofilm containing a drug component. The vascular stapler of the present invention can quickly and effectively connect end-to-end vascular intima without suturing, is convenient for anastomosis, is well positioned, and is not easy to move; moreover, the surface of the thin tube wall of the vascular stapler is not only beneficial to the intima tissue of the host vessel Crawling, growing, covering, fast healing, and effective treatment of vascular diseases; at the same time, the sleeve can play a supporting role and improve the patency of blood vessels, especially after the vascular intima heals, the degradable sleeve can quickly degrade and remove from the body The clinical events such as restenosis and complications in the late stage of non-degradable drug-eluting stents were solved.

Description

technical field [0001] The invention relates to a medical device, in particular to a degradable blood vessel stapler with a drug film layer and a preparation process thereof, which is suitable for end-to-end connection of lumen parts, especially blood vessel anastomosis. Background technique [0002] In minimally invasive interventional surgery, the end-to-end anastomosis of blood vessels, especially the anastomosis and connection of the two ends of the severed blood vessels, is one of the most basic techniques. The quality of anastomosis techniques and methods directly affects the success or failure of tissue and organ transplantation. At present, the traditional method is the most effective suturing method, but the process is complicated, the steps are cumbersome, the operation is difficult, the technique requires high precision, and the anastomosis requires less trauma. The suturing process is accurate and fast, but it is time-consuming and laborious in clinical operations...

Claims

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Application Information

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IPC IPC(8): A61B17/115
CPCA61B17/115A61B2017/00004A61B2017/00526A61B2017/1107A61B2017/1132
Inventor 李扬德滑有录李卫荣李卫
Owner DONGGUAN EONTEC CO LTD
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