A porous hydroxyapatite/titanium nitride bioactive coating capable of shielding release of harmful ions and its application

A technology of porous hydroxyapatite and hydroxyapatite, which is applied in the direction of coating, ion implantation plating, metal material coating technology, etc., can solve the problem of poor uniformity of coating prepared by laser cladding, difficulty in reaching 15.0MPa, plasma Spraying pyrolysis and other issues to achieve the effect of improving biocompatibility and biological activity, improving wear resistance, enhancing wear resistance and corrosion resistance and biological performance

Active Publication Date: 2019-02-22
CHINA UNIV OF MINING & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, sol-gel method, biomimetic mineralization method, hydrothermal synthesis and other wet preparation technologies generally have low bonding strength, and it is even difficult to reach the 15.0MPa required by the GB 23101.2-2008 standard; plasma spraying has pyrolysis and many cracks Defects such as poor uniformity of coating prepared by laser cladding, unstable performance and other problems

Method used

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  • A porous hydroxyapatite/titanium nitride bioactive coating capable of shielding release of harmful ions and its application
  • A porous hydroxyapatite/titanium nitride bioactive coating capable of shielding release of harmful ions and its application
  • A porous hydroxyapatite/titanium nitride bioactive coating capable of shielding release of harmful ions and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Use Ti-6Al-4V alloy, which is often used as bone plate, bone nail, and artificial joint replacement material, as the base material and follow the steps below:

[0058] (1) Cut the titanium alloy into φ30.0×3.0mm 3 Grind and polish the disc with 400#, 800#, 1200#, 1500#, 2000# diamond sandpaper, then wash it with distilled water, alcohol and acetone for 30.0min respectively, and then soak it in 3.0mol / L KOH lye 24.0 hours, then continue ultrasonic cleaning with distilled water for 40.0 minutes, and finally dry at 40.0°C for 24.0 hours for later use.

[0059] (2) Clean the substrate and target, install the substrate, high-purity Ti target and hydroxyapatite target in the vacuum sputtering chamber, and evacuate to 5.0×10 -5 Pa, argon gas is introduced into the sputtering chamber, the flow rate is 100.0sccm, the argon pressure in the sputtering chamber is maintained at 0.6Pa, and the position of the substrate is adjusted so that it faces away from the target; the bias volt...

Embodiment 2

[0066] Use 316L stainless steel, which is often used as bone plate, bone nail, and artificial joint replacement material, as the base material and follow the steps below:

[0067] (1) Cut 316L stainless steel into 30.0×30.0×2.0mm 3 Grind and polish the disc with 400#, 800#, and 1200# diamond sandpaper, then wash with distilled water, alcohol, and acetone for 30.0 minutes, and finally dry it at 40.0°C for 24.0 hours before use.

[0068] (2) Clean the substrate and target, install the substrate, high-purity titanium target and hydroxyapatite target in the vacuum sputtering chamber, and evacuate to 3.0×10 -5 Pa, argon gas is introduced into the sputtering chamber, the flow rate is 120.0sccm, the argon pressure in the sputtering chamber is maintained at 0.8Pa, and the position of the substrate is adjusted to make it face away from the target; The substrate is cleaned and activated by argon ion discharge for 30.0 minutes; the bias power is turned off, and the titanium target and hyd...

Embodiment 3

[0075] Use CoCrMo alloy, which is often used as artificial joint replacement material, as the base material and follow the steps below:

[0076] (1) Cut the CoCrMo alloy substrate into φ30.0×3.0mm 3 Grind and polish the wafer with 400#, 800#, 1200#, 1500# diamond sandpaper, then wash it with distilled water, alcohol and acetone for 30.0 minutes, then soak it in 3.0mol / L KOH lye for 24.0 hours, Then continue ultrasonic cleaning with distilled water for 40.0 minutes, and finally dry at 40.0° C. for 24.0 hours for use.

[0077] (2) Clean the target and substrate according to the process described in step 2 in Example 2.

[0078] (3) Deposit titanium as a bottom layer, adjust the substrate to face the target, turn on the titanium target and bias power, control the current to 3.0A, bias to -500.0V, maintain the argon pressure at 0.8Pa, and the flow rate at 150.0sccm , deposit titanium as a bottom layer on the substrate, and the deposition time is 2.0 minutes.

[0079] (4) Deposi...

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Abstract

The invention discloses a porous hydroxyapatite / titanium nitride bioactive coating capable of preventing harmful ion release and application of the porous hydroxyapatite / titanium nitride bioactive coating. The coating comprises a titanium base layer, a TiN gradient transition layer, a TiN layer, a hydroxyapatite gradient transition layer and a porous hydroxyapatite layer which are arranged from inside to outside. The porous hydroxyapatite layer is of a nano-mesoporous structure. The hydroxyapatite layer of the nano-mesoporous structure can remarkably improve the bioactivity of a medical metal implant, induce and promote growth of new bones and accelerate healing of bone injuries; through existence of the compact titanium nitride transition layer, the abrasion resistance and corrosion resistance of medical metal can be effectively improved, harmful ions can be effectively prevented from being released to human bodies, and adverse effects (such as irritability) caused for the harmful ions are avoided; and in addition, the obtained coating is even in surface thickness and performance, the binding strength of the coating and a substrate is high, and the preparation process is simple.

Description

technical field [0001] The invention relates to a porous hydroxyapatite / titanium nitride bioactive coating capable of shielding the release of harmful ions and a preparation method, belonging to the field of surface modification of biomedical metal materials. Background technique [0002] According to statistics, human hard tissue injuries such as osteoporosis, bone cancer, necrosis of the femoral head, fractures, and bone defects caused by population aging, sports trauma, work-related injuries, traffic accidents, natural disasters, and wars have resulted in a large number of patients Requires hard tissue repair and replacement surgery. At present, biomedical metal materials such as stainless steel, CoCrMo alloy, shape memory alloy such as NiTi alloy, pure titanium, titanium alloy and magnesium alloy have high bearing capacity, good toughness, easy processing, cheap raw materials and good biocompatibility. It is widely used as a hard tissue repair material. [0003] Howeve...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C14/35C23C14/06C23C14/16A61L27/30A61L27/32A61L27/50
CPCA61L27/306A61L27/32A61L27/50A61L2400/18A61L2420/02A61L2420/08A61L2430/02C23C14/0036C23C14/06C23C14/0641C23C14/165C23C14/345C23C14/352
Inventor 亓健伟陈章波贺丹枫杨意鸣王庆良
Owner CHINA UNIV OF MINING & TECH
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