Early diagnosis marker for lung cancer and diagnosis kit and application

A technology for early diagnosis and diagnostic reagents, applied in the field of medical biological detection

Inactive Publication Date: 2017-08-08
深圳瑞科生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

At present, there is still a lack of effective early diagnostic markers for lung cancer for the early diagnosis of smoking-related lung cancer

Method used

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  • Early diagnosis marker for lung cancer and diagnosis kit and application
  • Early diagnosis marker for lung cancer and diagnosis kit and application
  • Early diagnosis marker for lung cancer and diagnosis kit and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0040] Detecting the thromboxane content in lung tissue pathological sections of lung cancer mice and comparing it with the lung tissue thromboxane content of the control group, the specific steps are as follows

[0041] 1. Sample preparation:

[0042] The inventor selected 60 8-week-old SPF grade A / J female mice with a body weight of (20±3) g. The mice were purchased from the Model Animal Research Institute of Nanjing University with the license number: S(XK苏)201000001. Accurately weigh 220 mg of nitrosamine, dissolve it in 11 mL of normal saline to form a 20 mg·mL-1 NNK aqueous solution, and store it in a -20°C refrigerator in the dark for future use. The mice were numbered according to the number 1-60 with 0.1% picric acid staining solution, and the body weight was recorded. They were divided into two groups according to the principle of random block method, with 30 mice in each group. Grouped by Excel software according to the modeling time period as shown in Table 1, 30 ...

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Abstract

The invention relates to an early diagnosis marker for lung cancer and a diagnosis kit and application. Thromboxane can be used as the early diagnosis marker for the lung cancer, and comparison of thromboxane contents of experiment groups and control groups shows that the contents of the thromboxane in the experiment groups and the control groups are very remarkably different, the thromboxane is applicable to early identification and diagnosis of lung cancer and has good popularization and application values, and a novel clinical diagnosis method is provided for early diagnosis of lung cancer.

Description

technical field [0001] The invention relates to the technical field of medical biological detection, in particular to thromboxane as a lung cancer early diagnosis marker, a diagnostic kit and its application. Background technique [0002] Lung cancer has become the cancer with the highest mortality and incidence rate in the world. Epidemiological and laboratory research results have confirmed that 85-90% of lung cancer is related to smoking. At present, there is still a lack of effective early diagnostic markers of lung cancer for the early diagnosis of smoking-related lung cancer. [0003] Thromboxane has a strong vasoconstriction and bronchoconstriction effect, as well as a strong platelet aggregation effect. As a prostaglandin metabolized from cell membrane phospholipids, thromboxane is mainly involved in lung diseases, bronchial asthma, and pulmonary hypertension in the lungs. It has many physiological activities, including allergies, immune responses, angiogenesis, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
CPCG01N33/57423
Inventor 刘义
Owner 深圳瑞科生物科技有限公司
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