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An eye drop for the treatment of dry eyes

一种滴眼液、干眼的技术，应用在非有效成分的医用配制品、含有效成分的医用配制品、无机非有效成分等方向，能够解决脂溶性滴眼液先天不足无法完全克服等问题，达到保护角膜上皮屏障功能、好抗炎及免疫抑制效果、恢复数量的效果

Active Publication Date: 2021-01-05
EYE MEDICAL XIAMEN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even so, compared with water-soluble drugs, the inherent deficiencies of fat-soluble eye drops still cannot be completely overcome at present

Method used

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  • An eye drop for the treatment of dry eyes
  • An eye drop for the treatment of dry eyes
  • An eye drop for the treatment of dry eyes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] formula:

[0023]

[0024] Preparation Process:

[0025] 1. Accurately weigh 1.00g of midazoribine, 0.03g of benzalkonium chloride, 8.30g of sodium chloride, 30mL of 0.1mol / L hydrochloric acid, add 200mL of water for injection to dissolve, stir evenly, and dilute to 1000mL with water for injection to obtain liquid medicine.

[0026] 2. Filter the above solution once through a 0.45 μm microporous membrane, and then twice through a 0.22 μm microporous membrane.

[0027] 3. After the medicinal solution is qualified, fill 5.0mL of the above medicinal solution into a 5mL single-dose packaging plastic container in a grade A environment, and seal it to obtain the finished product.

Embodiment 2

[0029] formula:

[0030]

[0031] Preparation Process:

[0032] 1. Accurately weigh 1.00g of midazoribine, add 300mL of water for injection to dissolve it, and obtain solution ① for later use.

[0033]2. Accurately weigh 0.05g of chlorhexidine acetate, 7.20g of sodium dihydrogen phosphate, 0.95g of disodium hydrogen phosphate, and 4.79g of sodium chloride, add 200mL of water for injection to dissolve, stir and mix evenly to obtain a solution② spare.

[0034] 3. Mix solution ① and solution ②, stir evenly, and dilute to 1000mL with water for injection to obtain a medicinal solution.

[0035] 4. Filter the above medicinal solution once through a 0.45 μm microporous membrane, and then twice through a 0.22 μm microporous membrane.

[0036] 5. After the medicinal solution is qualified, fill 5.0mL of the above medicinal solution into a 5mL single-dose packaging plastic container in a grade A environment, and seal it to obtain the finished product.

Embodiment 3

[0038] formula:

[0039]

[0040] Preparation Process:

[0041] 1. Accurately weigh 1.00g midazoribine, 0.03g benzalkonium bromide, 6.40g sodium dihydrogen phosphate, 1.89g disodium hydrogen phosphate, 4.72g sodium chloride, 0.10g disodium edetate, add 200mL Dissolve in water for injection, stir evenly, and dilute to 1000mL with water for injection to obtain a medicinal solution.

[0042] 2. Filter the medicinal solution prepared above through a 0.45 μm microporous membrane once, and then through a 0.22 μm microporous membrane once.

[0043] 3. The filtered liquid medicine is sterilized at 121° C. for 8 minutes by autoclaving, and then cooled.

[0044] 4. After the medicinal solution is qualified, fill 5.0mL of the above medicinal solution into a 5mL single-dose packaging plastic container in a Class A environment, and seal it to obtain the finished product.

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PUM

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Abstract

The invention discloses an eye drop for treating dry eye, the pH is 5.0-7.0, and its active ingredient is 5-hydroxyl-1-beta-D-furanosyl-1H-imidazole-5-carboxamide, specifically It has the following composition by weight and volume percentage: 5-hydroxyl-1-beta-D-furanosyl-1H-imidazole-5-carboxamide 0.05-0.1%, an appropriate amount of pH regulator, and isotonic agent 0.01-3% , bacteriostat 0.003-0.5%, stabilizer 0.001-0.5%, thickener 0.01-0.5%, solubilizer 2-5%, and the balance is water. The local treatment of the eye drops of the invention can protect the corneal epithelial barrier function of dry eye mice, restore the number of conjunctival goblet cells, and have good anti-inflammatory and immunosuppressive effects.

Description

technical field [0001] The invention belongs to the technical field of dry eye treatment, and in particular relates to an eye drop for treating dry eye. Background technique [0002] Dry eye is a common and frequently-occurring disease in ophthalmology clinics. According to the large sample dry eye epidemiological survey conducted in the United States by Schaumberg et al.: the prevalence of dry eye in women under the age of 50 is 5.7%, and the prevalence rate rises to 9.8% after the age of 75, and the dry eye of women Symptoms are more obvious than men, and the higher the education level, the higher the prevalence rate; similarly, the prevalence rate of dry eye in men aged 50-54 is 3.9%, and the prevalence rate increases to 7.67%, it is estimated that by 2030, there will be 2.79 million male dry eye patients in the United States. In my country, according to the epidemiological survey results conducted by Shi Changhong et al., among the 31,124 patients included, the prevale...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7056A61K9/08A61K47/02A61K47/18A61K47/10A61K47/36A61K47/26A61K47/04A61P27/02
CPCA61K47/02A61K47/10A61K47/183A61K47/186A61K47/26A61K47/36A61K9/0048A61K9/08A61K31/7056A61P27/04A61K47/24
Inventor 刘祖国张晓博林祥
Owner EYE MEDICAL XIAMEN BIOTECHNOLOGY CO LTD
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