Unlock instant, AI-driven research and patent intelligence for your innovation.
A kind of natriuretic peptide polarization liquid and its preparation method and application
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A polarizing fluid and natriuretic peptide technology, applied in the field of medicine, can solve problems such as hemodynamics without consideration, achieve the effect of improving hemodynamics, unique curative effect, and reducing heart load
Inactive Publication Date: 2019-12-20
XIAN MEDICAL UNIV
View PDF2 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0005] The object of the present invention is to provide a natriuretic peptide polarized solution, which solves the problem that the existing GIK does not take into account the improvement of the patient's overall hemodynamics and the antagonism of the renin-angiotensin-aldosteronesystem to reduce the heart load and exert the heart. The question of protection
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
preparation example Construction
[0023] The preparation method of the natriuretic peptide polarization solution is specifically implemented according to the following steps:
[0024] Step 1, take glucose and potassium chloride, add water for injection to dissolve, depyrogenate, sterilize, and dry to make drug mixture component A;
[0025] Step 2: Take the drug component B composed of insulin and the drug component C composed of natriuretic peptide; add the drug components B and C to the drug mixture component A to prepare a polarizing solution containing natriuretic peptide.
[0026] Application of the present invention:
[0027] 1. In order to prove the protective effect of NP-GIK on ischemic heart, the following models and detection methods were used:
[0029] Thirty SD rats were randomly divided into normal saline group, NP-GIK group and sham operation group, with 10 rats in each group. After being anesthetized by intraperitoneal injection of 30g...
Embodiment 1
[0043] The composition of polarizing solution (NP-GIK) is: insulin 20U / L, glucose 200g / L, potassium chloride 80mmol / L and brain natriuretic peptide 50μg / L, and the solvent is water for injection.
[0044] The preparation method of the natriuretic peptide polarization solution is specifically implemented according to the following steps:
[0045] Step 1, take glucose and potassium chloride, add water for injection to dissolve, depyrogenate, sterilize, and dry to make drug mixture component A;
[0046] Step 2: Take the drug component B composed of insulin and the drug component C composed of brain natriuretic peptide; add the drug components B and C to the drug mixture component A to prepare a polarizing solution containing natriuretic peptide.
Embodiment 2
[0048] The composition of polarizing solution (NP-GIK) is: insulin 30U / L, glucose 150g / L, potassium chloride 100mmol / L and atrial natriuretic peptide 0.5μg / L, and the solvent is water for injection.
[0049] The preparation method of the natriuretic peptide polarization solution is specifically implemented according to the following steps:
[0050] Step 1, take glucose and potassium chloride, add water for injection to dissolve, depyrogenate, sterilize, and dry to make drug mixture component A;
[0051] Step 2: Take the drug component B composed of insulin and the drug component C composed of natriuretic peptide; add the drug components B and C to the drug mixture component A to prepare a polarizing solution containing natriuretic peptide.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
The invention discloses natriuretic peptide polarizing liquor. The natriuretic peptide polarizing liquor per liter comprises the following components: 20-50U of insulin, 50-200g of glucose, 50-100 micro mol of potassiumchloride and 0.5-100 micro gram of natriuretic peptide, wherein the solvent is water for injection. A preparation method comprises the following steps: adding water for injection into glucose and potassiumchloride for dissolving, removing pyrogen, sterilizing, and drying, so as to obtain a drug combination component A; respectively taking a drug component B composed of insulin and a drug component C composed of natriuretic peptides; and adding the drug component B and the drug component C into the drug combination component A, thereby obtaining the product. The natriuretic peptide polarizing liquor disclosed by the invention can directly act on cardiac muscles and can alleviate cardiac loads and achieve a heart protection effect by improving overall hemodynamics and performing antagonism on a rennin-angiotensin-aldosteronesystem. The natriuretic peptide polarizing liquor has unique curative effects on cardiac insufficiency and congestive heart failure and has wide clinical application prospects.
Description
technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a natriuretic peptide polarized liquid, and also relates to a preparation method and application of the natriuretic peptide polarized liquid. Background technique [0002] In 1962, Sodi-pallares first proposed that glucose-insulin-potassium (GIK) could be used as an adjuvant therapy for ischemic heartdisease. Common polarizing solutions are as follows: (1) conventional polarizing solution, intravenous infusion with 10 U of ordinary insulin and 10 ml of 10% potassium chloride added to 500 ml of 10% glucose solution. (2) Magnesium polarizing solution, intravenous infusion with 10 U of ordinary extrinsin, 10 ml of 10% potassium chloride and 10-20 ml of 10% magnesiumsulfate added to 500 ml of 10% glucose solution. (3) Intensify the polarization solution, add 10U of regular insulin, 10ml of 10% potassium chloride and 20ml of L-magnesium aspartate (L-PMA) into 300-500ml ...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
Login to View More