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Chinese medicine composite for treating cardiovascular diseases and preparation method thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition and its preparation for the treatment of cardiovascular diseases, and in the field of traditional Chinese medicine composition and its preparation, can solve the problems of single chemical drug treatment mechanism, affecting the efficacy of traditional Chinese medicine, poor patient compliance, etc. Achieve the effects of reducing myocardial oxygen consumption, increasing clearance, and increasing myocardial blood supply and oxygen supply

Inactive Publication Date: 2010-07-07
BEIJING ZHONGTAI TIANHE SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many drugs clinically used to treat cardiovascular diseases, mainly including nitrate preparations, adrenergic β-receptor blockers, calcium ion channel blockers, antiplatelet drugs, blood lipid-regulating drugs, thrombolytic drugs and blood-activating drugs. Blood stasis class traditional Chinese medicine preparations, etc., can play a certain therapeutic effect, but the chemical drug treatment mechanism is single, can not achieve comprehensive treatment goals, and is easy to relapse. Although traditional Chinese medicine in my country has shown good therapeutic effects in the treatment of cardiovascular diseases, However, due to the weak basic research, there are some deficiencies such as large dosage, slow onset of effect and poor patient compliance in clinical application, which have seriously affected the efficacy of traditional Chinese medicine in the treatment of cardiovascular diseases.

Method used

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  • Chinese medicine composite for treating cardiovascular diseases and preparation method thereof
  • Chinese medicine composite for treating cardiovascular diseases and preparation method thereof
  • Chinese medicine composite for treating cardiovascular diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0026] Experimental Example 1. Effects on Acute Myocardial Ischemia in Dogs

[0027] 1. Experimental grouping

[0028] 36 mongrel dogs (body weight 12~17kg, both male and female) are randomly divided into 6 groups, 6 in every group, sham operation control group, model control group, dropping pill 20mg / kg, 40mg / kg, 80mg / kg group of the present invention , Compound Danshen Dripping Pills 25mg / kg group.

[0029] 2. Experimental operation

[0030] Pentobarbital sodium 30mg / kg was injected intravenously for anesthesia. The dorsal position was fixed on the laboratory bench. The trachea was separated, a tracheal tube was inserted and connected to an artificial respirator, the left fourth intercostal space was opened to expose the heart, and the pericardium was cut. In the pericardial bed, the midsection of the left anterior descending coronary artery was separated and threaded for ligation. Multi-point fixed epicardial electrodes were sutured, and the electrodes were connected to ...

Embodiment 1

[0098] Sea buckthorn extract 55g Salvia extract 20g Chuanxiong extract 10g Borneol 45g

[0099] Take borneol and grind it into fine powder, mix it with the above extract evenly, add 220g of melted polyethylene glycol 6000, stir well, put it in the storage tank of the dropping pill machine and keep it warm (90°C), drop the drug solution into the cooling Put it in methyl silicone oil at 5°C, take out the dropping pills, remove the cooling liquid, and obtain 10,000 dropping pills.

Embodiment 2

[0101]Sea Buckthorn Extract 275g Salvia Extract 100g Chuanxiong Extract 50g Borneol 225g

[0102] Take borneol, use 6 times the amount of beta cyclodextrin to make clathrate, add the above extract, 1120g of microcrystalline cellulose, 20g of crospovidone, and 260g of starch, mix well, granulate with 70% ethanol, and dry , add micropowder silica gel 60g, crospovidone 180g and low-substituted hydroxypropyl cellulose 80g, evenly, tablet, obtain dispersible tablet.

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Abstract

The invention discloses a Chinese medicine composite for treating cardiovascular diseases and a preparation method thereof. The composite is prepared from the following ingredients in portion by weight: 20.0-85.0 per cent of seabuckthorn fruit extract, 2.0-45.0 per cent of salvia miltiorrhiza extract, 1.0-40.0 per cent of ligusticum chuanxiong extract, and 5.0-50.0 per cent of borneolum syntheticum. Through pharmacodynamic experiment, the result shows that the invention has the advantages of obviously increasing coronary flow and resisting myocardial ischemia, low dose, high active ingredient, fast medicine release, high bioavailability, definite efficacy and no toxic side effect, and the like.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a traditional Chinese medicine composition for treating cardiovascular diseases and a preparation method thereof, and belongs to the technical field of new medicines. Background technique [0002] Cardiovascular disease refers to vascular abnormalities in the heart and its adjacent large vessels such as the aorta, pulmonary artery, vena cava, and pulmonary vein, including heart disease, stroke, hypertension, and vascular diseases. [0003] Cardiovascular diseases are mainly affected by the elderly, and coronary heart disease, angina pectoris and myocardial infarction are common clinical diseases, which are one of the diseases with the highest morbidity and mortality. [0004] Cardiovascular disease is a multifactorial disease. Modern clinical research results show that cardiovascular disease is closely related to modern people's work ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P7/00A61P9/10A61P9/12A61K31/045
Inventor 何俊保
Owner BEIJING ZHONGTAI TIANHE SCI & TECH
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