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Nutritional compositions comprising sn-1(3) monoacylglycerols for use in the treatment of growth delay in infants or children

A kind of nutritional composition, technology of monoacylglycerol, applied in lipid field

Inactive Publication Date: 2017-08-18
NESTEC SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is also a need to deliver compositions in a manner that does not involve traditional pharmaceutical interventions because infants or young children are particularly delicate; that is convenient to implement and that is widely accepted by parents or healthcare professionals; and that is affordable to large Should be reasonable for most people and affordable for most people

Method used

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  • Nutritional compositions comprising sn-1(3) monoacylglycerols for use in the treatment of growth delay in infants or children
  • Nutritional compositions comprising sn-1(3) monoacylglycerols for use in the treatment of growth delay in infants or children
  • Nutritional compositions comprising sn-1(3) monoacylglycerols for use in the treatment of growth delay in infants or children

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0246] Table 1 below gives an example of the composition of an infant formula according to the invention. This composition is given by way of example only.

[0247] Table 1 : Examples of compositions of infant formulas according to the invention, eg formulas for premature infants

[0248]

[0249]

Embodiment 2

[0251] The concept was tested in a rat model of lipid maldigestion or malabsorption. use (ORLISTAT, tetrahydrolipstatin) to get a dyspepsia or malabsorption condition, Is a pancreatic lipase and gastric lipase inhibitor. For 21 days, rats were fed with a long-chain polyunsaturated fatty acid (LC-PUFA) supplement consisting mainly of eicosapentaenoic acid (EPA). Fish oil was used as a source of triacylglycerols and different EPA glycerides were evaluated: vanillin acetal of 2-EPA (from Stepan Lipid Nutrition Stepan Lipid Nutrition), 1,3 diacetyl- 2EPA (from Stepan Lipid Nutrition Stepan Lipid Nutrition) and sn-1(3)-MAG-EPA (available from Cognis GmbH, Germany).

[0252] Supplied at levels sufficient to reduce lipid absorption by 40% (ORLISTAT). will accept without (ORLISTAT) fish oil group was used as a positive control. Fatty acid profiles of erythrocyte lipids and plasma lipids were determined at different time intervals (D3, D7, D14 and D21). At the end of the ex...

Embodiment 3

[0257] This clinical study compared patients with Efficacy of sn-1(3) MAG and fish oil (TAG) to deliver EPA in humans with (ORLISTAT)-induced lipid dyspepsia disorder. Test comparisons were performed on volunteers who had treated to induce lipid dyspepsia or without (ORLISTAT) processing. The primary objective was to assess the accumulation of EPA in erythrocytes during a 21-day period of consumption as fish oil (TAG) or sn-1(3) MAG. Secondary objectives were to assess the accumulation of EPA in plasma over a 21-day period and to assess the pharmacokinetics of EPA after acute administration in the form of sn-1(3)MAG or TAG (AUC of chylomicrons at 10 hours postprandial ). see Figure 4 , which describes the clinical study timeline.

[0258] Table 2: Experimental groups

[0259]

[0260] Pharmacokinetic results ( Figure 5 ) shows that, compared to fish oil and (ORLISTAT) treatment with sn-1(3)MAG and (ORLISTAT) treatment produced an acute effect that was sta...

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PUM

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Abstract

The present invention refers to nutritional composition comprising sn-1(3) monoacylglycerols for use in the prevention / treatment of growth delay and / or in the promotion of growth in an infant or in a child like a young child, such as preterm and / or low birth weight infants.

Description

technical field [0001] The present invention relates generally to the field of lipids, and in particular to nutritional compositions comprising sn-1(3) monoacylglycerols for preventing / treating growth retardation and / or promoting growth retardation in infants or children (e.g. toddlers). grow. sn-1(3) monoacylglycerols may contain at least one functional fatty acid such as eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), eicosadonic acid, or arachidonic acid acid (ARA). The present invention also relates to the use of sn-1(3) monoacylglycerol in a nutritional composition to provide nutrition to an infant or child, such as a toddler. Background technique [0002] Lipids are normally consumed as triacylglycerols (TAGs). During digestion, pancreatic lipase is secreted from the pancreas. Pancreatic triglyceride lipase (PTL) is the main lipase in the human digestive system to hydrolyze dietary TAG molecules, converting TAG to diacylglycerol (DAG) and finally to monoac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/00A23L33/12A61K31/232A61P3/02
CPCA23L33/12A23L33/40A23V2002/00A61K31/232A23V2200/30A23V2200/314A23V2200/306A23V2200/326A23V2250/1872A23V2250/1874A23V2250/1868A23V2250/612A23V2250/54A23V2250/156A23V2250/70A61P3/02
Inventor L·阿梅耶C·克鲁兹-赫尔南德斯C·L·加尔奇亚-罗德纳斯
Owner NESTEC SA