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Dna vaccine composition for preventing and treating herpes zoster, and method for activating t cells for vzv antigen by using same

A DNA vaccine, a technology for herpes zoster, which is applied in the field of vaccines for the prevention and treatment of herpes zoster, can solve the problems of patients who cannot be immunosuppressed by herpes zoster, and achieves remarkable in vivo delivery efficiency, easy mass production, and improved stability. Effect

Inactive Publication Date: 2017-08-29
锦玟生命科学(株)
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  • Application Information

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Problems solved by technology

Furthermore, since the preventive vaccines against shingles currently on the market are attenuated vaccines, these preventive vaccines are in the paradoxical situation that they cannot be used in immunosuppressed patients with a high incidence of shingles

Method used

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  • Dna vaccine composition for preventing and treating herpes zoster, and method for activating t cells for vzv antigen by using same
  • Dna vaccine composition for preventing and treating herpes zoster, and method for activating t cells for vzv antigen by using same
  • Dna vaccine composition for preventing and treating herpes zoster, and method for activating t cells for vzv antigen by using same

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Embodiment approach

[0026] According to an exemplary embodiment of the present invention, the protein may include protein IE-62 (SEQ ID NO: 1) and protein IE-63 (SEQ ID NO: 2) and glycoprotein gE (SEQ ID NO: 3), Both of them can induce cellular immune response, and the plasmid is designed so that the gene encoding this protein can be inserted into the plasmid.

[0027] Administration of the plasmid DNA allows the plasmid DNA to mix with fluids in the body. For this reason, the plasmid DNA of the present invention can be designed to be introduced into the body with high efficiency using electroporation. Only when this method of electroporation is used, in vivo delivery efficiency can be maximized, thereby maximizing therapeutic efficacy. Body parts to which plasmid DNA is administered by electroporation include muscle parts and the like, but the present invention is not particularly limited thereto. For example, the body part can be determined in consideration of various factors such as age, typ...

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Abstract

The present invention provides a DNA vaccine composition for preventing and treating herpes zoster, containing: at least one type of plasmid containing the insertion site of a varicella-zoster virus (VZV)-derived gene encoding a VZV protein; and other pharmaceutically acceptable ingredients. The plasmid contains a plurality of plasmids containing the insertion site of heterologous genes which are different from each other. The plasmid contains: a first plasmid containing the insertion site of a first gene encoding IE-62 protein (SEQ ID NO: 1); a second plasmid containing the insertion site of a second gene encoding IE-63 protein (SEQ ID NO: 2); and a third plasmid containing the insertion site of a third gene encoding gE protein (SEQ ID NO: 3).

Description

technical field [0001] The present invention relates to a technology in the field of vaccination, more particularly, to a vaccine for the prevention and treatment of herpes zoster, which has excellent productivity, stability and immune reactivity to T cells and is suitable for use in multiple a disease condition. Background technique [0002] Typically, herpes zoster is a rash disease that progresses to varicella-zoster virus (VZV) and lies dormant in neuronal ganglions until the immune system weakens , and then induce VZV reactivation. When herpes zoster develops, bullous lesions form, and even when herpes zoster repairs, patients still have sequelae of postherpetic neuralgia. In this case, once the postherpetic neuralgia develops, it is difficult to completely cure the postherpetic neuralgia, and thus, the patient experiences excruciating pain. The reactivation of VZV and the onset of herpes zoster are associated with the attenuation of the cellular immune response in T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K48/00A61P31/22
CPCA61K39/12C07K14/005C12N15/85C12N2710/16734A61K2039/53C12N2710/16722A61P31/22A61K39/25A61K48/00A61K48/005A61K9/0019A61K2039/57A61K2039/70C12N2710/16741
Inventor 朴荣根赵炳文郑文燮李孝真蓸宁栏吴周妍
Owner 锦玟生命科学(株)
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