55 results about "Disseminated herpes zoster" patented technology

A composition and regimen for the treatment of herpes simplex and herpes zoster, primarily through elimination of the pathogenetic conditions by taking into account both pathogenesis and etiology thereof are disclosed. Administration of 1) repeated large dosages of vitamin B2 to eliminate severe vitamin B2 deficiency inherent in herpes simplex and herpes zoster; 2) Strobilanthes cusia and Berberine to ameliorate febrile illness and to clear “hot” condition; 3) Zizyphus semen to relieve psychological stress; and 4) L-lysine to antagonize arginine and alleviate anxiety-all these hereof are for eliminating the pathogenetic conditions. These, in combination with antiviral agents if necessary, constitute the scope and the spirit of the present invention.

The invention discloses a medicine for curing herpes zoster, which is composed of following raw materials: Baical Skullcap Root 12, Gardenia 12, taraxacum 12, Chinese violet 15, wild chrysanthemum 15, Coptis Root 15, phellodendron 15, honeysuckle 15, Andrographis paniculata 18, red paeonia 18, moutan bark 18 and rhubarb 10; utilizing the medicine can cure the herpes zoster with obvious effects, rapid recovery, few side effects and little recrudescence with a effective ratio of 95% and a recovery ratio of 90%.

The invention relates to the technical field of biomedicine, and particularly provides varicella-zoster virus gB-gE-gH-gL fusion protein, a genetic engineering subunit vaccine and preparation methods. The fusion protein comprises a VZV gB extracellular region, a gE extracellular region, a gH truncated fragment and a gL truncated fragment. The amino acid sequence of encoded protein of the fusion protein is SEQ ID NO:1, and one amino acid sequence is SEQ ID NO:2. A prokaryotic expression vector is utilized for constructing escherichia coli BL21 (DE3) host bacteria capable of expressing the VZV gB-gE-gH-gL fusion protein. The fusion protein is purified and mixed with a medicinal adjuvant to be prepared into the genetic engineering subunit vaccine. Compared with a currently-used VZV attenuated live vaccine, the vaccine can induce immune mice to generate higher specific humoral immunity and cell-mediated immunity and can prevent dormant infection that VZV is spread to dorsal root ganglions and intestinal ganglions through blood flow, the safety of the VZV vaccine is effectively improved, and therefore the genetic engineering subunit vaccine is an alternative vaccine with potential clinical application value.

An interior-applied Chinese medicine for treating herpes zoster is proportionally prepared from portulaca, dandelion herb, isatis leaf and corydalis tube.

The invention relates to a medicinal composition for herpes zoster which is prepared from the following raw materials (by weight ratio) through conventional processes: seed of cowherb 50-65%, corydalis ambigua 25-40%, and borneol 5-12%.

The invention discloses externally-applied medicine for treating herpes zoster. The externally-applied medicine is prepared from, by weight, 2-8 parts of pearls, 5-15 parts of calculus bovis, 5-15 parts of realgar, 2-8 parts of borneol, 5-15 parts of arenobufagin, 5-15 parts of musk, 5-15 parts of panax notoginseng, 5-15 parts of cinnabar and 25-35 parts of rice vinegar. According to the externally-applied medicine, raw materials are scientifically and reasonably matched and support one another, and through combination of the raw medical materials, the effects of clearing away heat and toxic materials and activating blood to promote menstruation and relieve pain are realized, treatment time is short, and the medicine becomes effective fast and is free of toxic and side effects. The medicine is especially suitable for treating herpes zoster.

The invention belongs to the field of traditional Chinese medicine, and particularly relates to Pien Tze Huang and new application of a preparation thereof in preparing a drug for treating herpes zoster. An in-vitro experiment shows that Pien Tze Huang can dose-dependently inhibit duplication of chicken varicella-herpes zoster viruses (VZV). A clinical study finds that the combination of Pien Tzehuang and anti-virus drugs of valaciclovir and acyclovir has an obvious curative effect on alert period zoster viruses due to liver yu heat from the line, improvement of clinical symptoms of a patientcan be promoted, incrustation of herpes can be quickly promoted, new herpes can be stopped from generating, pain can be relieved, and the treatment time can also be shortened; besides, the incidenceof postherpetic neuralgia and the occurrence rate of adverse reactions occurring after treatment can also be lowered, and the clinical application has obvious advantages.

The invention discloses a drug for treating acute toxic heat flaming herpes zoster. The drug is prepared from more than ten crude drugs such as felwort, scutellaria baicalensis, jasmine, rhizoma alismatis, caulis akebiae and the like according to a certain weight ratio. The drug is an oral decoction, and has the effects of nourishing of liver and spleen, and tonification and purgation in combination. An external lotion for treating the disease is also disclosed by the invention, and is prepared from six drugs such as fructus forsythia and root bark of the peony tree. The drug disclosed by the invention can be significant in curative effect in internal and external therapy of the disease, high in recovery rate and not easy to reappear.

The invention discloses an external Chinese medicinal composition for treating herpes zoster, belongs to the technical field of Chinese pharmaceutical manufacturing, and in particular relates to the technical field of Chinese pharmaceutical manufacturing of the external Chinese medicinal composition for treating herpes zoster. The contents of the invention are that the external Chinese medicinal composition for treating herpes zoster is specially prepared from the following medicines: 1-9g of iron rusts, 2-10g of unslaked limes, 1-8g of realgar and 1-8g of earthworm shits. The external Chinese medicinal composition has the characteristics of less use amount of medicines and easiness for using, and has an obvious treatment effect.

The invention belongs to the field of virus vaccines and discloses a preparation method of a herpes zoster vaccine. Through combination use of a glycoprotein E envelope outer structural domain of the herpes zoster and a glycosylation locus area of envelope glycoprotein I, the herpes zoster vaccine is established, the envelope glycoprotein I, interacting with glycoprotein E of the herpes zoster, on a herpes zoster virus envelope, of the herpes zoster virus assists the glycoprotein E envelope outer structural domain of the herpes zoster in preparation of the herpes zoster vaccine, the glycosylation modification level of a vaccine protein complex is improved, the similarity of the vaccine protein complex and a natural virus envelope is improved, and the immunocompetence of the herpes zoster vaccine is improved.

The present invention relates to one kind of externally applied medicine for treating herpes zoster. The externally applied medicine for treating herpes zoster is prepared through mixing sesame oil as the solvent and fine powder of cowherb seed, pangolin scales, gromwell and natural indigo. It has high healing rate and effective rate.

Varicella-zoster virus belongs to the herpesvirus family and its main host are humans, producing 2 different diseases: varicella in children and young adults and zoster in elder or immunodepressed subjects. We reported in the scientific medical literature the unexpected finding that the role of varicella-zoster virus in the pathogeny of Multiple Sclerosis (Archives of Neurology 61: 529-532). This finding allows us to foresee the use of a vaccine against this virus with preventive and therapeutic ends for multiple sclerosis which eventually could also be applicable in the prevention of varicella and zoster. Currently the only vaccine used in humans is that produced by attenuated live varicella-zoster viruses, this latter feature thus avoiding its therapeutic use in multiple sclerosis, wherein the chronic disease is caused by periodic exacerbations of the virus which remains latent in the host, therefore by injecting an attenuated and viable virus the infection may be exacerbated and promote the very latency of the vaccine virus.

In our studies the most conspicuous genes of the varicella-zoster virus found in multiple sclerosis patients were the ones corresponding to the genes ORF31 (gB), ORF67 (gI) and ORF68 (gE). The recombinant vaccine which is the subject of this patent is built up by the proteins generated by these genes inserted in a plasmid vector of pNMT1-TOPO in order to transform Schizosaccharomyces pombe and thus obtaining the recombinant viral proteins which build up the vaccine.

This vaccine, by being made from recombinant viral proteins eliminates the risks associated to the use of vaccines from attenuated viable viruses. Likewise, the use of these recombinant viral proteins is specific and sensitive to serological tests for the diagnosis of infections caused by the varicella-zoster virus.

The invention relates to the application of a traditional Chinese medicine composition to preparation of medicines used for treating diseases caused by herpes virus infection. A prescription for the traditional Chinese medicine composition comprises, 80 parts by weight of Rhizoma Atractylodis, 80 parts by weight of dried orange peel, 80 parts by weight of Cortex Magnolia, 120 parts by weight of dahurian angelica roots, 120 parts by weight of Poria cocos, 120 parts by weight of areca peel, 80 parts by weight of raw pinellia ternate, 10 parts by weight of Extractum Glycyrrhizae, 0.8 part by volume of patchouli oil and 0.4 part by volume of perilla leaf oil. The traditional Chinese medicine composition uses tradition traditional Chinese medicines as raw materials, has small toxic and side effect and obvious treatment effect on herpes zoster, and can prevent and treat postherpetic neuralgia. No matter in a systemic administration manner or a local administration manner, the traditional Chinese medicine composition has better effect compared with the common medicine acyclovir. The traditional Chinese medicine composition can shorten the curing time of herpes, helps patients to get rid of the shadow of disease as early as possible, and is beneficial for the physical and mental health of patients.

The invention discloses a method for treating chronic neuropathic pain caused by herpes zoster. Safely take the underground root diameter of the scallion to ensure the integrity of its root bark; (2) Application: apply the white juice of the removed scallion underground root to the affected area immediately, three times a day, if it cannot be applied externally in time, use it immediately Seal its broken end with earth to prevent the juice from running off; take it back after digging, cut the root diameter of the scallion into 1 section every 3-4cm during external application, and apply the white juice to the affected part immediately, 3 times a day, the present invention can Effectively relieve severe neuropathic pain caused by herpes zoster and improve the cure rate of herpes zoster.

The invention provides a medicament for treating herpes zoster and preparation method of medicament. The medicament comprises the following raw materials in parts by weight: 1500-3500 parts of edible original white vinegar, 20-30 parts of zanthoxylum bungeanum, 20-30 parts of cortex pseudolaricis, 5-10 parts of lytta vesicatoria, 10-15 parts of artemisia apiacea, 10-15 parts of borneol and 5-10 parts of realgar. By virtue of scientific collocation of the Chinese herbal plants, the medicament serves as an externally-applied medicament for treating herpes zoster, and is safe and free of side effects.

The invention discloses an external application medicine for treating herpes zoster. The medicine is characterized by comprising, by weight, 15 parts of bear gall powder, 20 parts of realgar, 5 partsof arenobufagin, 30 parts of rheum officinale, 30 parts of platycodon grandiflorum, 50 parts of gypsum, 35 parts of radix scutellariae, 35 parts of honeysuckles, 15 parts of borneol and 500 parts of mature vinegar. The raw materials are scientific in composition and reasonable in compatibility and support one another, the medicines are used together, and the external application medicine has the effects of clearing away heat and toxic materials, promoting blood circulation to remove meridian obstruction and relieving pain, is short in treatment time, takes effect quickly, is high in cure rate,free of toxic and side effects and especially suitable for treating herpes zoster, and truly achieves the effects of simplicity, convenience, low cost and effectiveness.

The invention discloses a composite medicament used for treating herpes zoster. The composite medicament used for treating the herpes zoster is composed of 5 to 10 mL of 2 percent lidocaine injection, 0.5 to 1.0 mg of VitB12 injection, 5 to 10 mg of dexamethasone injection and 1 to 2 mL of bacillus calmette guerin polysaccharide nucleic acid injection. The medicament is used for point injection for treating the herpes zoster. The medicament has the characteristics of quick response, small dosage, safety, high cure rate, good stability and small harm to a human body. The medicament is suitable for treating the herpes zoster.

The invention relates to the field of traditional Chinese medicine preparations, in particular to an external medicine for treating herpes zoster. The external medicine is prepared from, by weight, 0.5-3 parts of deltoid goldthread rhizomes, 0.5-3 parts of Chinese corktree barks, 0.5-3 parts of dandelion herbs, 0.5-3 parts of Ginseng roots, 0.5-3 parts of common cnidium fruits, 0.1-2 parts of myrrh, 0.1-2 parts of borneol, 0.1-2 parts of gypsum, 0.1-2 parts of talc, 0.1-2 parts of cuttle bones, 0.1-2 parts of rhizoma corydalis and 0.1-2 parts of dragon's blood. The external medicine has the major functions of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis and relieving pain and itching and mainly treats the herpes zoster. Through clinical experiments, the pain is relieved 10 minutes after the medicine is applied, blisters shrink within 20 hours, scabs are formed within seven days, and crusts fall off within 15 days. Particularly, healed neuropathic pain and itching symptoms of patients can be eliminated. Hundreds of cumulative patients practically use the external medicine, curative ratio is 100%, and curative effects are remarkable.

The invention discloses a medicine for treating herpes zoster and a preparation method thereof. The medicine comprises the following raw materials in parts by weight: rhubarb 13-17, dandelion 13-17 part, 15 centipedes-25 part, isatis root 13-17 part, honeysuckle 13-17 portions, 13 borneol-17 part, rhizoma Cyperi 13-17 part, fructus Toosendan 13-17, Pheretima 8-12 part, 13 safflower-17, Zelan 13-17, Yuanhu 13-17. A Chinese medicinal composition is prepare by mixing that above medicinal material with 75% alcohol 500-1000 ml soak 6-8 days. The medicine has the characteristics of quick onset, goodcurative effect, safety and no toxic and side effects, and is simple in preparation method and convenient in use. The total effective rate was 86.6%.