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Sutureless Repair of Soft Tissue

A soft tissue and tissue technology, applied in the direction of tissue regeneration, ligaments, prosthesis, etc., can solve problems such as heating tissue damage

Active Publication Date: 2021-05-28
ORTHOCELL PTY LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many reasons, but heating the tissue necessarily causes damage and thus its use in the clinical field has not been realized disregarding all the preclinical studies in the field of laser welding

Method used

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  • Sutureless Repair of Soft Tissue
  • Sutureless Repair of Soft Tissue
  • Sutureless Repair of Soft Tissue

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0152] Example 1: Method for preparing collagen membrane

[0153] Collagen fragments from porcine internal organ linings were carefully isolated and placed in a solution containing about 70% ethanol and incubated briefly at room temperature. The collagen-containing tissue is then stretched with the fat side up on the working surface and as much fat tissue and blood vessels as possible are removed.

[0154] To visualize the presence of adipose tissue, collagen-containing tissue was coated with glycerol for about 10 minutes. At this point the collagen is transparent, but the adipose tissue is white. Separate the white adipose tissue from the collagen using forceps under a dissecting microscope.

[0155] Upon completion, the collagen-containing tissue was carefully transferred to a sealed container and incubated in a solution containing approximately 1% (v / v) SDS and 0.2% (v / v) LiCl to denature non-collagenous proteins. Incubate overnight at 4°C.

[0156] The collagen-contain...

Embodiment 2

[0169] Example 2: Tendon Repair

[0170] Fifty albino New Zealand white rabbits (Oryctolagus cuniculus), 12 to 20 weeks old, weighing 3-5 kg, were used. All rabbits were bred from an outbred rabbit population maintained in the animal house of the University of Western Australia (Nedlands, Australia). Rabbits were fed rabbit / guinea pig pellets, hay and water ad libitum. Rabbits were housed in cages 1.5 m wide, 0.75 m long, and 0.75 m high with a grid floor to prevent foot dermatitis. All surgical procedures and cage activities were performed under strict guidelines as detailed by the National Health and Medical Research Council (NHMRC, Canberra, Australia).

[0171] Fifty rabbits were randomly assigned to two groups of 25 and anesthetized by intramuscular injection of ketamine (Parke-Davis, Auckland, NZ) and xylazine (Troy Laboratories Australia). A longitudinal incision was made on the left shoulder and surgical exposure of the rotator cuff tendon was accomplished by releas...

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Abstract

The present application relates to sutureless methods for repairing soft tissue defects in soft tissue including ligaments such as the anterior cruciate ligament (ACL). In particular, the present application relates to a sutureless method of repairing a soft tissue defect, said method comprising: (i) providing a collagen-containing patch adapted to surround at least part of said soft tissue defect; (ii) making said soft tissue defect and / or contacting the collagen-containing patch with a sensitizer; (iii) enclosing the soft tissue defect in the collagen-containing patch to form a bioactive cavity; and (iv) adhering the collagen-containing patch to The soft tissue defect was not sutured.

Description

technical field [0001] The present application relates to sutureless methods for repairing soft tissue defects in soft tissue including ligaments such as the anterior cruciate ligament (ACL). The repair includes repairing a partial or complete tear. In particular, the present application relates to a sutureless method of repairing a soft tissue defect comprising adhering a collagen-containing patch to the site of the soft tissue defect using a sensitizing agent, wherein a bioactive cavity is formed around the soft tissue defect providing a Helps repair the microenvironment of the tissue. Background technique [0002] Tendon tissue, ligament tissue, vascular tissue, skin tissue, etc. are generally referred to as soft tissue. Ligaments are specialized connective soft tissues that connect different organs or tissues and attach bone to bone. In the latter case, the ligaments provide stability to the joint by being flexible enough to allow the bones to move naturally, but at t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/32A61L27/58A61F2/08
CPCA61B17/00491A61B17/11A61B17/1128A61B17/1146A61B2017/00508A61B2017/0065A61B2017/00659A61B2017/1107A61B2017/1132A61F2/0036A61F2/08A61L27/24A61L27/50A61L2430/10A61L2430/34A61L27/58
Inventor M·H·郑
Owner ORTHOCELL PTY LTD
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