Bi-component compound artemether dry suspension for treating malaria and preparation method of dry suspension

A technology for treating malaria and dry suspension, which is applied in the field of malaria treatment, can solve the problems of the stability of the drug administration form of the treatment effect, etc., and achieve the effects of obvious effect, improved curative effect, and convenient transportation

Inactive Publication Date: 2017-09-08
NINGBO SHUANGWEI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of them are prepared by unilateral preparations such as artemisinin or its derivatives. Although artemisinin derivatives have a good effect on the treatment of malaria, the therapeutic effect sometimes depends on the unilateral preparation, dosage, and administration

Method used

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  • Bi-component compound artemether dry suspension for treating malaria and preparation method of dry suspension
  • Bi-component compound artemether dry suspension for treating malaria and preparation method of dry suspension
  • Bi-component compound artemether dry suspension for treating malaria and preparation method of dry suspension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0022] Preparation of raw materials (design according to each bottle containing 180mg of artemether and 1080mg / 60ml / bottle of lumefantrine), as shown in Table 1 below:

[0023] Table 1

[0024]

[0025]

[0026] Concrete preparation method is:

[0027] 1. Slurry preparation: prepare 60% ethanol solution with purified water, then add aspartame and carmellose sodium to dissolve it for later use;

[0028] 2. Granulation: Grind artemether and sucrose through a 100-mesh sieve respectively, then mix them with other raw and auxiliary materials in an equal increment method, and then place them in a mixer to mix evenly; add an appropriate amount of binder and stir to make a suitable soft material; Granulate with a 20-mesh nylon sieve; fine powder is required;

[0029] 3. Drying: Dry at 60°C for 2 to 3 hours;

[0030] 4. Grain granulation and total blending: add additional auxiliary materials and pass through a 20-mesh sieve for granulation and then mix evenly; the moisture con...

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Abstract

The invention discloses a bi-component compound artemether dry suspension for treating malaria and a preparation method of the dry suspension. The dry suspension is characterized by being prepared from the following raw materials in parts by weight: original auxiliary materials: 0.05-0.10 part of artemether, 0.2-0.8 part of lumefantrine, 2.5-4 parts of saccharose, 2-3 parts of lactose, 0.05-0.3 part of aspartame, 0.05-0.15 part of sodium carboxymethylcellulose and 1-2 parts of 60% ethanol; and additional auxiliary materials: 0.03-0.10 part of xanthan gum, 0.03-0.10 part of a coconut essence, 0.03-0.10 part of a fresh milk flavor and 0.15-0.35 part of silicon dioxide. The bi-component compound artemether dry suspension is sweet and fragrant after being eaten, is easily accepted by children and is obvious in action effect.

Description

technical field [0001] The invention relates to the technical field of malaria treatment, in particular to a two-component compound artemether dry suspension for treating malaria and a preparation method thereof. Background technique [0002] Malaria is a vector-borne disease caused by infection with Plasmodium parasites through mosquito bites or blood transfusion of people with Plasmodium parasites. The main manifestations of this disease are periodic attacks, chills, fever, and sweating all over the body. After repeated attacks for a long time, anemia and splenomegaly can be caused. At present, antimalarial drugs can be prepared from artemisinin, artemether, artesunate and the like. However, most of them are prepared by unilateral preparations such as artemisinin or its derivatives. Although artemisinin derivatives have a good effect on the treatment of malaria, the therapeutic effect sometimes depends on the unilateral preparation, dosage, and administration. The shape ...

Claims

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Application Information

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IPC IPC(8): A61K31/357A61K9/50A61K47/38A61K47/26A61K47/04A61P33/06A61K31/137
CPCA61K9/5084A61K31/137A61K31/357A61K47/02A61K47/26A61K47/38A61K2300/00Y02A50/30
Inventor 孙伟东
Owner NINGBO SHUANGWEI PHARMA
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