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Quickly-absorbed hemostatic ligating clip

A ligation clip and fast technology, which is applied in the fields of coating, medical science, surgery, etc., can solve the problems of not being able to apply clipping first and then separating after acute bleeding, requiring high technical proficiency of the operator, and not being able to close normally, so as to avoid Tissue irritation and foreign body reaction, facilitates degradation and absorption, and prevents pollution

Pending Publication Date: 2017-09-08
ZHEJIANG APELOA JIAYUAN BIOMEDICAL MATERIAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Before the ligation operation of the absorbable clip closes the tissue, it is necessary to separate the tissue blocking the front end of the clip to complete the ligation operation. Otherwise, it is easy to cause human tissue to be caught at the clip closure, which cannot be closed normally, and the tissue is blocked. Repeated pulling, which causes damage to the tissue
This has resulted in two important deficiencies: 1. High requirements for the operator's technical proficiency; 2. It cannot be applied to operations such as acute bleeding, clipping first and then separation (such as hepatic lobectomy, etc.)
Since the inner layer is made of polydioxanone, the human body can absorb this material for a long time (about 10 months to fully absorb); and the shelf life of the product is short, only one and a half years

Method used

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  • Quickly-absorbed hemostatic ligating clip

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Glycolide-carbonate copolymer material preparation:

[0027] 191 grams of polymer grade glycolide and 9 grams of cyclocarbonate were placed in a reactor, 0.02% of stannous octoate catalyst was added, and the reaction was carried out at 120° C. for 10 hours under high vacuum conditions. Take it out, crush it into granules, dry the above granules in vacuum at 50° C. for 24 hours, weigh 185 grams, and the yield is 92.5%. Using hexafluoroisopropanol as a solvent, the intrinsic viscosity of the glycolide-carbonate copolymer was measured to be 4.36dl / g with an Ubbelohde viscometer in a constant temperature water bath at 25°C.

[0028] The glycolide-carbonate copolymer was measured, and the glycolide unit accounted for 95.1%.

[0029] Preparation of degradation solution: refer to the standard of ISO13781:1997 to prepare Sorensen buffer solution with a pH value of 7.4±0.2.

[0030] The material was degraded in Sorensen's buffer solution in vitro for 16 weeks, and lost more th...

Embodiment 2

[0036] Glycolide-carbonate copolymer material preparation:

[0037] 106 grams of polymer grade glycolide and 94 grams of cyclocarbonate were placed in a reactor, 0.02% of stannous octoate catalyst was added, and the reaction was carried out at 130° C. for 24 hours under vacuum conditions. Take it out, crush it into granules, dry the above granules in vacuum at 50° C. for 24 hours, weigh 178 grams, and the yield is 89%. Using hexafluoroisopropanol as a solvent, the intrinsic viscosity of the glycolide-carbonate copolymer was measured to be 2.68dl / g with an Ubbelohde viscometer in a constant temperature water bath at 25°C.

[0038] Glycolide-carbonate copolymer was measured, and the glycolide unit accounted for 50.2%.

[0039] The material was degraded in Sorensen's buffer solution in vitro for 26 weeks, and lost more than 60% of its weight.

[0040] Processing of absorbable hemostatic ligation clip:

[0041] The glycolide-carbonate copolymer synthesized above is processed in...

Embodiment 3

[0043] Glycolide-carbonate copolymer material preparation:

[0044] 145 grams of polymer grade glycolide and 55 grams of cyclocarbonate were placed in a reactor, 0.02% stannous octoate catalyst was added, and the reaction was carried out at 120° C. for 20 hours under vacuum conditions. Take it out, crush it into granules, dry the above granules in vacuum at 50° C. for 24 hours, weigh 180 grams, and the yield is 90%. Using hexafluoroisopropanol as a solvent, the intrinsic viscosity of the glycolide-carbonate copolymer was measured to be 3.14dl / g with an Ubbelohde viscometer in a constant temperature water bath at 25°C.

[0045] The glycolide-carbonate copolymer was measured, and the glycolide unit accounted for 70.1%.

[0046] The material is degraded in Sorensen's buffer solution in vitro for 24 weeks, and its weight loss exceeds 60%.

[0047] Processing of absorbable hemostatic ligation clip:

[0048] The glycolide-carbonate copolymer synthesized above is processed into an...

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Abstract

The invention discloses a quickly-absorbed hemostatic ligating clip. The quickly-absorbed hemostatic ligating clip is divided into an inner layer and an outer layer, the outer layer is made from polyglycollide, the inner layer is made from biodegradable aliphatic polyester containing structural units shown in the formula I and the formula II, and A and B are independently selected form C1-C6 alkylene. The quickly-absorbed hemostatic ligating clip has the advantages of quick absorption by human body (complete absorption in around 6 months) and long storage life of the product.

Description

technical field [0001] The invention relates to a special consumable for performing surgical operations, more specifically, the invention relates to a hemostatic ligation clip made of absorbable material. Background technique [0002] At present, in surgical operations, metal clips or clips of non-absorbable materials are often used to ligate tubular tissues in the human body for the purpose of hemostasis or sealing. Metal clips, such as titanium clips, will not be degraded and absorbed by the human body, and stay in the body for a long time, which may irritate the tissue and cause inflammation; at the same time, the metal clip will be developed in the X-ray examination, causing doctor's misjudgment. Although the clip of non-absorbable material will not affect the X-ray inspection, it will not be absorbed in the human body and will also cause tissue irritation. Absorbable hemostatic ligation clips have appeared in the 1980s. Compared with metal clips and non-absorbable cli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/10A61L17/12A61L17/14
CPCA61L17/105A61L17/12A61L17/145C08L69/005C08L67/04
Inventor 吴侃何晓东蔡凡凯龙杏
Owner ZHEJIANG APELOA JIAYUAN BIOMEDICAL MATERIAL
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