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Artificial biological canula and its making process

A manufacturing method and biological technology, applied in the field of biomedical materials, can solve the problems of poor resistance to normal saline, and achieve the effects of poor water resistance, excellent resistance to normal saline solubility, and prolonged absorption cycle

Inactive Publication Date: 2006-02-01
BEIJING HUIFUKANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to its poor resistance to physiological saline, there has been no report on its use in the preparation of absorbable artificial biological sleeves.

Method used

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  • Artificial biological canula and its making process
  • Artificial biological canula and its making process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Dissolve commercially available sodium alginate with a molecular weight of 500,000 in water to obtain a high-viscosity solution with a concentration of 6% (W:W), and vacuumize and defoam until a foam-free spinning stock solution is obtained. The spinning dope is extruded from the kettle with 0.6MPa air pressure, metered by the spinning metering pump, extruded from the cortex of the hollow spinneret hole, and directly enters the coagulation bath, which is 1.5% hydrochloric acid (W:W) and 0.5 % calcium chloride (W:W) in water. At the same time, the coagulation bath was extruded from the core layer of the hollow spinneret hole with an air pressure of 0.2 MPa. The extruded spinning dope is coagulated under the simultaneous action of the external coagulation bath and the core layer coagulant, drawn out by guide rollers and drawn 1.4 times to obtain continuous alginic acid-calcium alginate hollow round tubes with an inner diameter of 0.95 mm, the thickness of the pipe wall i...

Embodiment 2

[0043] Others are the same as in Example 1, the difference is that 4wt% sodium alginate containing 7wt% (relative to the weight of sodium alginate) nerve growth factor (NGF: bFGF: compound Hongqi injection = 1: 1: 1.5 weight ratio) is used The aqueous solution is a spinning stock solution, and hollow spinneret holes with corresponding pipe diameters and wall thicknesses are used, and the coagulation bath is an aqueous solution containing 1.5% calcium chloride and 0.3% nerve growth factor. The obtained calcium alginate hollow tube was repeatedly treated three times with 0.5% dilute acetic acid solution containing 0.3% nerve growth factor (bath ratio 1:10w:w, each treatment time was 20 minutes), and the obtained drug-containing alginic acid-alginic acid The ratio of alginic acid: calcium alginate: nerve growth factor in the calcium hollow tube is 10:3.8:1, and then placed in 0.7% (W:W) of chitosan with a deacetylation degree of 82% and a molecular weight of 150,000. Growth facto...

Embodiment 3

[0045] Dissolve chitosan with a deacetylation degree of 89% and a molecular weight of 360,000 in 2% dilute acetic acid solution to obtain a solution with a chitosan concentration of 5%. The chitosan solution was added dropwise with distilled water under stirring to dilute it to 0.5% acetic acid concentration and 1.25% chitosan concentration. Add 28% nerve growth factor relative to the weight of chitosan (NGF: bFGF: compound Hongqi injection = 1:1:1.5 weight ratio) into the above diluted chitosan solution and stir evenly to obtain chitosan-nerve growth factor mixed liquid. Soak the thin non-woven needle-punched calcium alginate fiber net (30 g / m2 specification, self-made) with a mixture of 2% acetic acid aqueous solution: acetone = 50:50, wash three times, dehydrate with pure acetone, air-dry, and then use carapace Fully impregnate the amine-nerve growth factor mixture for 20 minutes, take out the polytetrafluoroethylene cylindrical rod with a diameter of 6mm as the roller, an...

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Abstract

The artificial biological canula is made using sodium alginate as main material, the water solution of hydrochloric acid-calcium chloride as solidifying agent, and through hollow fiber spinning and drawing process to produce hollow circular alginin acid-calcium alginate tube with desired size and physical and mechanical performance; chemical treatment of the tube with chitinamine solution to produce artificial biological canula with excellent normal saline resistance and proper absorption period. To the artificial biological canula, proper amount of nerve growth promoting factor may be added to prepare medicine slow-release artificial biological canula. The absorbable artificial biological canula has excellent biocompatibility, no toxic and inflammation reaction and controllable absorption period.

Description

【Technical field】 [0001] The present invention relates to an artificial biological casing and a manufacturing method thereof, in particular to an absorbable artificial biological casing with chitosan alginate-calcium alginate as the main component, which can guide and promote effective regeneration of nerves, and a manufacturing method thereof. It belongs to the field of biomedical materials. 【Background technique】 [0002] Peripheral nerve injuries are very common in clinical practice. At present, the method of suturing peripheral nerve injuries with epineurium or perineurium is generally used in clinical practice. However, because the above-mentioned methods cannot guarantee the matching of motor bundles and sensory bundles, the repair effect is not good. ideal. [0003] In order to perform qualitative anastomosis of nerve bundles in surgery, people have conducted studies on the location of nerve function bundles from the aspects of anatomy and immunohistochemistry for...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04A61L29/04A61K38/18
Inventor 姜保国孙玉山傅中国朱庆松张殿英林华体李剑张彩霞任侠飞陆伊伦
Owner BEIJING HUIFUKANG MEDICAL TECH
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