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Carvacrol-containing nanoemulsion and preparation method thereof

A carvacrol, nanoemulsion technology, applied in the directions of botanical equipment and methods, chemicals for biological control, and repellents, etc., can solve problems affecting bioavailability and scope of application, poor stability, easy oxidation, etc. problem, to achieve the effect of improving bioavailability, strong stability and low cost

Active Publication Date: 2021-12-07
NAT UNIV OF SINGAPORE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because carvacrol is insoluble in water, volatile, poor in stability, and easily oxidized, it affects its bioavailability and scope of application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] This example is an example of preparation and property testing of the nanoemulsion composition of the present invention.

[0029] 1. Preparation of carvacrol nanoemulsion composition:

[0030] 0.50 g of carvacrol and 1.25 g of corn oil were weighed and mixed to form an oil phase, then 1.75 g of Tween-80 and 5.00 g of propylene glycol were added to the oil phase and stirred to obtain a mixed oil phase;

[0031] Add 50.00 g of acidic electrolyzed water and 41.50 g of deionized water to the mixed oil phase obtained in the above steps, and stir to obtain a mixed solution;

[0032] The mixed solution was placed in an ultrasonic cell disruptor for ultrasonic treatment, the ultrasonic power was 1000 W, the ultrasonic frequency was 20 kHz, and the ultrasonic time was 10 min to obtain carvacrol nanoemulsion.

[0033] The acidic electrolyzed water used in the above-mentioned preparation steps can be an aqueous solution formed by electrolyzing 18% (w / v) sodium chloride by an elec...

Embodiment 2

[0042] This example is an example of preparation and property testing of the nanoemulsion composition of the present invention.

[0043] 1. Preparation of carvacrol nanoemulsion composition:

[0044] 0.50 g of carvacrol and 2.00 g of corn oil were weighed and mixed to form an oil phase, then 2.00 g of Tween-80 and 6.00 g of propylene glycol were added to the oil phase and stirred to obtain a mixed oil phase;

[0045] Add 50.00 g of acidic electrolyzed water and 39.50 g of deionized water to the mixed oil phase obtained in the above steps, and stir to obtain a mixed solution;

[0046] The mixed solution was placed in an ultrasonic cell disruptor for ultrasonic treatment, the ultrasonic power was 1000 W, the ultrasonic frequency was 20 kHz, and the ultrasonic time was 10 min to obtain carvacrol nanoemulsion.

[0047] The acidic electrolyzed water used in the above-mentioned preparation steps can be an aqueous solution formed by electrolyzing 18% (w / v) sodium chloride by an elec...

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PUM

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Abstract

The invention relates to a carvacrol-containing nanoemulsion composition and a preparation method thereof. The nanoemulsion composition of the present invention contains carvacrol, corn oil, Tween-80, propylene glycol, acidic electrolyzed water and deionized water. The preparation method of carvacrol nano-emulsion in the present invention specifically comprises: take carvacrol and corn oil as oil phase, add Tween-80 and propylene glycol and stir evenly, then add acidic electrolyzed water and deionized water and stir evenly, carry out mixed solution Ultrasonic treatment to obtain nanoemulsion. The nanoemulsion and the preparation method of the invention are novel and reasonable in design, the obtained nanoemulsion has strong stability, good antibacterial effect, simple production process and low cost, and is suitable for large-scale popularization and application.

Description

technical field [0001] The invention belongs to the field of fungicides, in particular to a carvacrol-containing nanoemulsion and a preparation method thereof. Background technique [0002] Carvacrol, also known as nepetol, is a colorless to pale yellow thick oily liquid with a special aromatic odor. It is commonly found in various natural plants and volatile oils of plants, such as oregano volatile oil, thyme volatile oil, Shixiangru whole grass and camphor wood, etc. Carvacrol has strong antibacterial and anthelmintic effects, and is used in food additives, feed additives, fungicides, preservatives and other fields. However, carvacrol is insoluble in water, volatile, has poor stability, and is easily oxidized, which affects its bioavailability and application range. SUMMARY OF THE INVENTION [0003] Based on this, the purpose of the present invention is to provide a carvacrol-containing nanoemulsion composition and a preparation method thereof, which can improve the st...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N25/04A01N31/08A01P1/00A01P3/00A01P17/00
CPCA01N25/04A01N31/08
Inventor 杨宏顺苏丽卿黄慧丽
Owner NAT UNIV OF SINGAPORE