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Leukoderma compound granule preparation and preparation method thereof

A granule preparation, vitiligo technology, applied in the field of vitiligo compound granule preparation and its preparation, can solve the problems of inconvenient carrying, large dosage, etc., achieve the effect of increasing the content, definite curative effect, and avoiding toxic and side effects

Inactive Publication Date: 2017-10-10
杨爱霞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] According to the survey, most of the dosage forms of traditional Chinese medicine for the treatment of vitiligo are mixtures, which have the disadvantages of inconvenient transportation and carrying and large dosage

Method used

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  • Leukoderma compound granule preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A preparation method of vitiligo compound granules, comprising the steps of:

[0029] Step 1: Take 31 parts of Angelica sinensis, add 310 parts of water to soak for 1 hour, then heat and extract with steam for 5 hours to obtain the volatile oil of Angelica sinensis. Finally, obtain the extract of Moutan Cortex and the dregs of Moutan Cortex for later use; combine the volatile oil of Angelica Sinensis and the extract of Moutan Cortex, add 10 times the sum of the volatile oil of Angelica Sinensis and the extract of Moutan Cortex, and add β-cyclodextrin at 50°C for 2 hours , get clathrate;

[0030] Step 2: Take 62 parts of Caulis japonica, add 12.4 parts of ethanol with a volume fraction of 95%, and heat it under CO at 40MPa and 60°C. 2 Supercritical extraction for 2 hours to obtain the extract of the twig, and the dregs of the twig for subsequent use;

[0031] Step 3: Mix the dregs of Angelica sinensis, Cortex Moutan, and Caulis japonica with 62 parts of Tribulus terres...

Embodiment 2

[0033] A preparation method of vitiligo compound granules, comprising the steps of:

[0034] Step 1: Take 32 parts of Angelica sinensis, add 320 parts of water to soak for 1 hour, then heat and extract with steam for 5 hours to obtain the volatile oil of Angelica sinensis, and the dregs of Angelica sinensis for later use; take 31 parts of Moutan bark, add 310 parts of water, soak at 40°C for 0.5 hours, and heat and extract for 4 hours Finally, obtain the extract of Moutan Cortex and the dregs of Moutan Cortex for later use; combine the volatile oil of Angelica Sinensis and the extract of Moutan Cortex, add 10 times the sum of the volatile oil of Angelica Sinensis and the extract of Moutan Cortex, and add β-cyclodextrin at 50°C for 2 hours , get clathrate;

[0035] Step 2: Take 62 parts of Caulis japonica, add 12.4 parts of ethanol with a volume fraction of 95%, and heat it under CO at 40MPa and 60°C. 2 Supercritical extraction for 2 hours to obtain the extract of the twig, an...

Embodiment 3

[0038] A preparation method of vitiligo compound granules, comprising the steps of:

[0039]Step 1: Take 32 parts of Angelica sinensis, add 320 parts of water to soak for 1 hour, then heat and extract with water vapor for 5 hours to obtain Angelica sinensis volatile oil, and the dregs of Angelica sinensis for later use; Take 32 parts of Moutan cortex, add 320 parts of water, soak at 40°C for 0.5 hours, heat and extract for 4 hours Finally, obtain the extract of Moutan Cortex and the dregs of Moutan Cortex for later use; combine the volatile oil of Angelica Sinensis and the extract of Moutan Cortex, add 10 times the sum of the volatile oil of Angelica Sinensis and the extract of Moutan Cortex, and add β-cyclodextrin at 50°C for 2 hours , get clathrate;

[0040] Step 2: Take 63 parts of Caulis japonica, add 12.6 parts of ethanol with a volume fraction of 95%, and heat it under CO at 40MPa and 60°C. 2 Supercritical extraction for 2 hours to obtain the extract of the twig, and th...

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Abstract

The invention discloses a compound granule preparation for vitiligo and a preparation method thereof. The compound granule preparation is made of the following raw materials in parts by weight: 60-64 parts of Tribulus terrestris, 60-64 parts of Caulis Spatholobus, 60-64 parts of Spathiphyllum vine, 60‑64 parts of rattan, 60‑64 parts of rehmannia, 29‑33 parts of Moutan bark, 29‑33 parts of red peony, 29‑33 parts of angelica, 29‑33 parts of salvia. In the preparation method of the vitiligo compound granule preparation provided in the present invention, the active ingredients of each drug are better enriched and the impurities are removed to the greatest extent through the corresponding extraction process, and the content of the active ingredients of the drug is improved; The preparation method prepares the vitiligo compound granule preparation, the content of the active components is higher than that of the mixture type, the curative effect is definite, the toxic and side effects caused by excessive dosage are avoided, and the needs of the majority of patients are met.

Description

technical field [0001] The invention relates to a compound granule preparation, in particular to a vitiligo compound granule preparation and a preparation method thereof. Background technique [0002] Vitiligo is a skin disease caused by acquired depigmentation, which is called "Vitiligo" or "White Bark Wind" in traditional Chinese medicine. It is a skin and mucous membrane disease characterized by localized or generalized depigmentation caused by the dysfunction and loss of the tyrosine system in melanocytes of the skin and hair follicles, and has localized and systemic characteristics. At present, the worldwide incidence of vitiligo is about 0.5% to 1%, and it is 25% to 30% in childhood, and it is on the rise. Although the disease is easy to diagnose, it is very difficult to treat. Although the disease will not pose a threat to people's health, it will bring many unfavorable factors to the appearance of the patient and bring many shadows to the life of the patient. Affec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/16A61P17/00
CPCA61K36/804A61K9/1652A61K36/185A61K36/232A61K36/486A61K36/537A61K36/65A61K36/704A61K36/71A61K36/74A61K2236/331A61K2236/37A61K2236/51
Inventor 杨爱霞易艳东林世和何伟肖卫红易凯程璐王晓仙黄铁花
Owner 杨爱霞
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