Application of CREBZF to treatment, prevention and diagnosis of metabolic diseases

Abstract

The invention relates to application of CREBZF to treatment, prevention and diagnosis of metabolic diseases and particularly provides application of reagents to preparation of medicines for retarding object weight gain, reducing object blood glucose and blood fat, improving object liver fat deposition, improving object glucose tolerance and / or retarding object hepatic cell lipid accumulation. The reagents include a reagent for reducing object CREBZF protein expression and / or a reagent for lowering object expressed CREBZF protein activity. According to a constructed liver specific CREBZF knockout mouse model, liver specific CREBZF knockout remarkably retards weight gain of a mouse under high-fat high-carbohydrate diet induction, reduces blood glucose and blood fat, improves mouse liver fat deposition, improves glucose tolerance and retards hepatic cell lipid accumulation.

Description

technical field [0001] The present invention relates to the application of CREBZF in the treatment, prevention and diagnosis of metabolic diseases. Background technique [0002] With the improvement of modern people's living standards and changes in dietary structure, the incidence of metabolic syndrome (MS) represented by obesity, type 2 diabetes, fatty liver, hyperglycemia, and hyperlipidemia is increasing year by year and presenting On the rise, hyperlipidemia due to fat metabolism disorder is the main cause of other chronic diseases such as fatty liver, obesity, coronary heart disease and atherosclerosis. Therefore, finding drug targets that can effectively prevent and control metabolic disorders has important practical significance for the prevention and treatment of metabolic diseases. The molecular indicators related to the metabolic syndrome represented by the above will play a positive role in the clinical molecular diagnosis, treatment and prevention of the diseas...

AI Technical Summary

Problems solved by technology

Preliminary studies on the function of CREBZF in biochemical molecules have been carried out before [Xie, Y.-B., B.Nedumaran and H.-S.Choi, Molecular characterization of SMILE as novel corepressor of nuclear receptors. Nucleic Acids Research, 2009.37( 12): p.4100-4115; Xie, Y.-B., etc., Transcriptional Corepressor SMILE RecruitsSIRT1toInhibit Nuclear Receptor Estrogen Receptor-related ReceptorγTransactivation.Journal of Biological Chemistry, 2009.284(42):p.28762-28774F], but for CREBZ Mechanisms of how metabolism is regulated under conditions of excess nutrition are poorly understood

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