Solid multiple self-emulsifying carrier and preparation method thereof
A technology of self-emulsification and carrier, which is applied in the direction of pharmaceutical formula, emulsion delivery, active ingredients of hydroxyl compounds, etc., to achieve the effect of improving stability and solving application defects
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Embodiment 1
[0052] The formula of this embodiment is as follows:
[0053]
[0054] see figure 1 Shown, the preparation steps of this embodiment are as follows:
[0055] Step 1) Weigh 1g of tea polyphenols and 20g of deionized water, stir to dissolve completely and stir evenly to form an aqueous solution containing active substances as the water phase;
[0056] Weigh 1g of resveratrol, 15g of corn oil, and 6g of polyglycerol ricinoleate, stir to make it completely dissolve and stir evenly, as the oil phase;
[0057] Step 2) Slowly pour the water phase into the oil phase, and stir for 10 minutes at the same time, after mixing evenly, 16000rpm high shear for 5 minutes;
[0058] Step 3) Adding 7g of decaglycerol monolaurate to the mixture obtained in step 2), stirring to mix evenly to obtain a liquid multiple self-emulsifying carrier loaded with active substances;
[0059] Step 4) Take 50g of anhydrous calcium hydrogen phosphate and the liquid multiple self-emulsifying carrier, mix them...
Embodiment 2
[0062] The formula of this embodiment is as follows:
[0063]
[0064] see figure 1 Shown, the preparation steps of this embodiment are as follows:
[0065] Step 1) Weigh 2g of ascorbic acid and 20g of deionized water, stir them mechanically to dissolve them completely, and form an aqueous solution containing active substances as the water phase;
[0066] Weigh 1g of quercetin, 15g of coconut oil, 5g of glycerin, and 5g of polyglycerol ricinoleate, heat and stir in a water bath at 70°C to completely dissolve and stir evenly, as the oil phase;
[0067] Step 2) Slowly pour the water phase into the oil phase, and stir for 10 minutes at the same time, mix evenly, 600bar high-pressure homogenization for 3 cycles;
[0068]Step 3) Continue to add 7g of polyoxyethylene sorbitan fatty acid ester to the mixture obtained in step 2, and stir and mix evenly to obtain a liquid multiple self-emulsifying carrier loaded with active substances;
[0069] Step 4) Take 45g of aluminum magnes...
Embodiment 3
[0072] The formula of this embodiment is as follows:
[0073]
[0074] see figure 1 Shown, the preparation steps of this embodiment are as follows:
[0075] Step 1) Weigh 25g of deionized water as the water phase;
[0076] Weigh 1g astaxanthin, 19g aloe vera oil, 5g sorbitan monostearate, stir to make it dissolve completely and stir evenly, as the oil phase;
[0077] Step 2) Slowly pour the water phase into the oil phase, and stir for 10 minutes at the same time, mix evenly, 600bar high-pressure homogenization for 3 cycles;
[0078] Step 3) Continue to add 5 g of polyoxyethylene sorbitan fatty acid ester into the mixture prepared in step 2), and stir and mix evenly to obtain a liquid multiple self-emulsifying carrier loaded with active substances;
[0079] Step 4) Take 45g of aluminum magnesium silicate and the liquid multiple self-emulsifying carrier, mix them thoroughly, and then sieve to obtain the solid multiple self-emulsifying carrier.
[0080] The solid multiple ...
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Abstract
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