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Nano pearl powder/C-HA composite support and application thereof

A nano-pearl powder and composite scaffold technology, applied in the field of bioengineering, can solve the problems of poor accuracy, slow degradation, and high brittleness of bioactive ceramics, and achieve the effects of favorable proliferation, good wettability, and good biological activity

Active Publication Date: 2017-10-20
海口市人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bioactive ceramics can promote the growth and differentiation of osteoblasts, however, their clinical applications are limited due to their shortcomings such as high brittleness, difficulty in shaping, and very slow degradation.
In addition, bioactive ceramics are less precise, and new bone formed on porous ceramic scaffolds cannot sustain the mechanical load required for load-bearing bone
Therefore, its clinical application is also subject to more restrictions

Method used

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  • Nano pearl powder/C-HA composite support and application thereof
  • Nano pearl powder/C-HA composite support and application thereof
  • Nano pearl powder/C-HA composite support and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 3

[0046] 1. Reagents, as shown in Table 2

[0047] Table 2

[0048] Reagent

company and model

micron pearl powder

Hainan Nanjing Run Pearl Biotechnology Co., Ltd.

Sodium hyaluronate

H107141, Aladdin

Chitosan

C105803, Aladdin

acetic acid

Analytical pure, Aladdin

[0049] 2. The instrument is shown in Table 3

[0050] table 3

[0051]

[0052]

[0053] 3. Operation steps

[0054] 1) Grind the micron pearl powder into nano pearl powder by mechanical ball milling with a nano ceramic sand mill disperser, dry and sterilize;

[0055] 2) Dissolve 4wt% chitosan and 1wt% hyaluronic acid into 1% acetic acid solution respectively, stir for 5min at a speed of 2000rpm in a Thinky mixer, and place it at room temperature for 24h to obtain chitosan acetic acid solution and hyaluronic acid acid acetic acid solution;

[0056] 3) After 24 hours, mix the chitosan acetic acid solution and the hyaluronic acid acetic acid solution...

Embodiment 1 Embodiment 5

[0063] 2. Experimental reagents and instruments

[0064] The same as the reagent of embodiment and instrument

[0065] 1) Experiment 1: Determination of the surface morphology of the composite scaffold

[0066] 1. Observation of the surface morphology of composite scaffolds by scanning electron microscopy

[0067] Cut the sample into thin slices with a width of 3 mm to make the surface of the sample as flat as possible. After drying with a vacuum freeze dryer, stick the samples on the conductive adhesive in turn, mark the upper left corner of the conductive adhesive, and spray gold on the surface of the sample for 60 seconds. Then open the sample chamber of the scanning electron microscope (MIRA3, Czech Republic), fix the sample to be observed, vacuumize, and directly observe the cross-sectional morphology with the scanning electron microscope.

[0068] 2. Conclusion

[0069] Such as figure 1 As shown, the scaffold is highly porous with uniformly distributed pores and goo...

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Abstract

The invention discloses a nano pearl powder / C-HA composite support. The support is prepared from the following raw materials including nano pearl powder, hyaluromic acid, chitosan and acetic acid, and the weight percentage of the nano pearl powder is 1 to 25 percent. The invention aims to provide the nano pearl powder / C-HA composite support which has a suitable pore structure, is beneficial for proliferation of cells, growth of blood vessels and transportation of nutrient substances, has good biological activity, biocompatibility and biodegradability, and can adapt to a special shape of bone defect and application of the nano pearl powder / C-HA composite support.

Description

technical field [0001] The invention relates to the field of bioengineering, in particular to a nano pearl powder / C-HA composite bracket. Background technique [0002] Bone defects have become a global health problem. With the aging of the population and the development of society, the repair of bone defects has become an important clinical topic and social demand. At present, the clinical treatment of bone defects mainly relies on allogeneic bone grafting or autologous bone grafting, but there are many limitations in these two treatment methods. For a long time, autologous bone transplantation has been recognized as the gold standard of bone transplantation, but there are disadvantages such as limited amount of available bone, complications at the donor site, and easy absorption of transplanted bone blocks; allogeneic bone transplantation has immune rejection and transmission of infectious diseases risks of. [0003] With the development of medicine, biology and material...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/50A61L27/44
CPCA61L27/446A61L27/50A61L27/56A61L2430/02C08L5/08
Inventor 李晓妮徐普
Owner 海口市人民医院
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