Flammulina velutipes polysaccharide, extraction method and its application in preparation of medicine for treating functional constipation
A technology of Flammulina velutipes polysaccharide and functional constipation, which is applied in the extraction and preparation of medicines for treating functional constipation.
Active Publication Date: 2019-04-02
HENAN UNIVERSITY
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Problems solved by technology
At present, there are many studies on Flammulina velutipes polysaccharides, the main effects of which are anti-fatigue, anti-oxidation, anti-tumor, anti-aging and improving memory, etc., but no research and reports on the treatment of functional constipation by Flammulina velutipes polysaccharides have been found
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Embodiment 1
[0017] A kind of Flammulina velutipes polysaccharide, which is extracted and obtained through the following steps: Take 706.21 g of Flammulina velutipes solid powder, first use petroleum ether to degrease three times at room temperature, the amount of petroleum ether added three times is 1500mL, 800mL and 500 mL respectively, each time The extraction time is 1 day. After the leaching finishes, filter, and the filter residue is dried and weighed to obtain 698.83g Flammulina velutipes powder residue. Then the enoki mushroom powder residue was leached three times with 75% ethanol at room temperature to remove small molecules. The amount of 75% ethanol added three times was 2000 mL, 550 mL, and 500 mL respectively, and the leaching time was 1 day each time. After the leaching is finished, filter and dry to obtain 581.14 g of residue. Add water to the residue at a ratio of 1 g to 20 mL of solid-liquid, and then decoct at 90°C for three times, each decocting for 3 h. After decocti...
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The invention discloses an extraction method of flammulina velutipes polysaccharide. The method is concretely characterized in that crushed needle mushroom entities are sequentially subjected to room temperature digestion by petroleum ether and 75+ / -10 percent ethanol; the obtained residue is subjected to hot decoration and boiling by water at 90+ / -5 DEG C; filtering is performed; filtering liquid is subjected to alcohol deposition; precipitates are taken and are sequentially washed by absolute ethyl alcohol, acetone and petroleum ether; then, freeze drying is performed; the flammulina velutipes polysaccharide is obtained. The invention also discloses application of the flammulina velutipes polysaccharide to an aspect of the preparation of medicine for treating functional constipation. Through experiments, the effects that the flammulina velutipes polysaccharide can obviously raise the contents of MTL (motillin), GAS (gastrin) and P substances in blood serum, and can reduce the content of SS (somatostatin), so that the functional constipation can be effectively relieved are discovered. The result shows that the flammulina velutipes polysaccharide belongs to ideal medicine for treating the functional constipation.
Description
technical field [0001] The invention belongs to the technical field of polysaccharide medicines, and in particular relates to Flammulina velutipes polysaccharides, an extraction method and its application in the preparation of medicines for treating functional constipation. Background technique [0002] Functional constipation (functional constipation, FC) is a common gastrointestinal disease, constipation caused by factors such as changes in life patterns, emotional depression, dietary factors, poor bowel habits, drug effects, for example, people who travel, Due to the influence of factors such as the law of life, changes in the surrounding environment, and fatigue, constipation often occurs, and this type of constipation belongs to functional constipation. [0003] Generally speaking, the clinical symptoms of functional constipation are difficulty in defecation and prolonged defecation time. Constipation has a great impact on the patient's quality of life, and even threat...
Claims
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IPC IPC(8): C08B37/00A61K31/715A61P1/10
CPCA61K31/715A61K36/07C08B37/0003
Inventor 康文艺辛昕王学标牛英颖
Owner HENAN UNIVERSITY