Cymene water-based formula and application thereof in external skin preparation

An external preparation, hydrocarbon water-based technology, applied in skin care preparations, skin diseases, cosmetic preparations, etc., can solve problems such as cymene precipitation, enhance stability, enhance application comfort, and avoid low-temperature crystals. Precipitation effect

Inactive Publication Date: 2017-10-24
SHANGHAI ZHONGYI DAILY CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The object of the present invention is to provide a kind of cymene water-based formula

Method used

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  • Cymene water-based formula and application thereof in external skin preparation
  • Cymene water-based formula and application thereof in external skin preparation
  • Cymene water-based formula and application thereof in external skin preparation

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0086] Example 1-Water-based skin topical formulation of 8o-cymen-5-ol

[0087] The formula is shown in Table 4:

[0088] Table 4 o-cymene-5-ol water-based skin external preparation without precipitation

[0089]

[0090] The preparation method of above-mentioned o-cymene-5-alcohol water-based skin external preparation, comprises the steps:

[0091] 1) Phase A is the main phase, first add the normal temperature water of phase A into the main pot, then add the remaining components of phase A, control the stirring so as not to stir up water, heat to 80 ~ 85 ℃, keep warm for 15 minutes, ensure that phase A is completely dissolved, and add The loss of water does not exceed 1%, and the temperature is lowered to 40-45 ° C with stirring.

[0092] 2) Phase B is heated to 50°C, premixed and dissolved in advance, and cooled to 40-45°C. Add phase C, premix and stir evenly, add to the main pot, and then add the raw materials of phase D separately.

[0093] 3) Stir and cool to 35±2℃...

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PUM

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Abstract

The invention discloses a cymene water-based formula which is prepared from the following raw materials in parts by weight: 0.01-0.1 part of cymene, 1.5-20 parts of a wetting agent, 0-7.0 parts of ethanol and 0.01-1.0 part of a solubilizer. According to the formula, the problem that the cymene tends to be separated out in the formula system is solved. The formula can further serve as a component in a transparent external drug preparation or an external skin preparation and is high in stability.

Description

technical field [0001] The invention belongs to the technical field of medicine and external skin preparations, and particularly relates to a cymene water-based formula and its application in external skin preparations. Background technique [0002] According to current research, the growth of acne is induced by anaerobic bacteria, among which Propionibacterium acnes is the main bacteria that causes acne, which can cause skin inflammation and explosive infection. Many people, especially those with oily skin, suffer from acne, which seriously affects daily life and social activities. Therefore, it is of great significance to find an efficient, less irritating, and safe method for acne treatment. [0003] o-Cymene-5-ol (Isopropyl methyphenol, referred to as IPMP) is a safe, efficient and stable bactericidal preservative, and has been approved by the FDA for direct or indirect applications in food, drugs, and cosmetics review team (CIR) approval In cosmetics, the use concentra...

Claims

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Application Information

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IPC IPC(8): A61K8/34A61K8/39A61K8/86A61K8/63A61K8/9789A61K8/67A61K8/92A61Q19/00A61Q17/00A61K31/05A61K47/10A61K47/44A61P17/10A61P31/04A61P31/02
Inventor 袁旻嘉杨珍林艺青孙培文
Owner SHANGHAI ZHONGYI DAILY CHEM CO LTD
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