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Cymene water-based formula and application thereof in external skin preparation

An external preparation, hydrocarbon water-based technology, applied in skin care preparations, skin diseases, cosmetic preparations, etc., can solve problems such as cymene precipitation, enhance stability, enhance application comfort, and avoid low-temperature crystals. Precipitation effect

Inactive Publication Date: 2017-10-24
SHANGHAI ZHONGYI DAILY CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The object of the present invention is to provide a kind of cymene water-based formula, which solves the problem that cymene tends to separate out in the formulation system

Method used

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  • Cymene water-based formula and application thereof in external skin preparation
  • Cymene water-based formula and application thereof in external skin preparation
  • Cymene water-based formula and application thereof in external skin preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-8

[0086] Water-based external skin preparation of embodiment 1-8o-cymene-5-ol

[0087] Formula is as shown in table 4:

[0088] Table 4 O-cymene-5-alcohol water-based external skin preparation without precipitation formula

[0089]

[0090] The preparation method of the above-mentioned O-cymene-5-alcohol water-based external preparation for skin comprises the following steps:

[0091] 1) Phase A is the main phase, first add the normal temperature water of phase A into the main pot, then add the remaining components of phase A, control the stirring so as not to set off splashes, heat to 80-85°C, keep warm for 15 minutes, ensure that phase A is completely dissolved, and add Loss of water does not exceed 1%, stirring to cool down to 40-45 ℃.

[0092] 2) Heat phase B to 50°C, pre-mix and dissolve in advance, and cool down to 40-45°C. Add phase C, pre-mix and stir evenly, add to the main pot, then add the raw materials of phase D separately, control the stirring so as not to st...

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Abstract

The invention discloses a cymene water-based formula which is prepared from the following raw materials in parts by weight: 0.01-0.1 part of cymene, 1.5-20 parts of a wetting agent, 0-7.0 parts of ethanol and 0.01-1.0 part of a solubilizer. According to the formula, the problem that the cymene tends to be separated out in the formula system is solved. The formula can further serve as a component in a transparent external drug preparation or an external skin preparation and is high in stability.

Description

technical field [0001] The invention belongs to the technical field of medicine and external skin preparations, and particularly relates to a cymene water-based formula and its application in external skin preparations. Background technique [0002] According to current research, the growth of acne is induced by anaerobic bacteria, among which Propionibacterium acnes is the main bacteria that causes acne, which can cause skin inflammation and explosive infection. Many people, especially those with oily skin, suffer from acne, which seriously affects daily life and social activities. Therefore, it is of great significance to find an efficient, less irritating, and safe method for acne treatment. [0003] o-Cymene-5-ol (Isopropyl methyphenol, referred to as IPMP) is a safe, efficient and stable bactericidal preservative, and has been approved by the FDA for direct or indirect applications in food, drugs, and cosmetics review team (CIR) approval In cosmetics, the use concentra...

Claims

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Application Information

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IPC IPC(8): A61K8/34A61K8/39A61K8/86A61K8/63A61K8/9789A61K8/67A61K8/92A61Q19/00A61Q17/00A61K31/05A61K47/10A61K47/44A61P17/10A61P31/04A61P31/02
Inventor 袁旻嘉杨珍林艺青孙培文
Owner SHANGHAI ZHONGYI DAILY CHEM CO LTD
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