Dithiole pyrrolidone compound nanometer suspension and a preparation method thereof
A technology of dithiocyclopentene and nanosuspension, which is applied in directions such as drug combination, drug delivery, and pharmaceutical formulation, can solve the problems of unimproved bioavailability, easy aggregation of particles, unstable products, and the like, To achieve the effect of improving the dissolution rate, not easy to aggregate, and easy to operate
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Embodiment 1
[0055] prescription:
[0056]
[0057] Preparation:
[0058] Weigh the prescribed amount of PEG-4000, Tween 80, and ZL004 and add them to the prescribed amount of water for injection, mix well, dissolve or swell the above-mentioned excipients to form a solution, then add them together with ZL004 to the planetary ball mill, mix Mix evenly to form a grinding material mixture, add 30 agate grinding beads with a diameter of 1.0 mm, put it in a planetary ball mill, and grind for 60 minutes at a speed of 600 rpm. After grinding, use sodium chloride to adjust the osmotic pressure to isotonicity, and use sodium citrate to adjust the pH value to 7 to obtain the product;
[0059] After diluting the prepared suspension, measure the particle size and Zeta potential, the volume average particle size is 755.0nm, and the Zeta potential is -19.2mv. Particle size distribution see figure 1 .
Embodiment 2
[0061] prescription:
[0062]
[0063]
[0064] Preparation:
[0065] Weigh the prescribed amount of sodium carboxymethylcellulose, Tween 80, and ZL004 and add them to the prescribed amount of water for injection, mix well, dissolve or swell the above-mentioned excipients to form a solution, and then add them together with ZL004 to the planetary ball mill , mix well to form a grinding material mixture, add 30 agate grinding beads with a diameter of 1.0 mm, put it in a planetary ball mill, and grind for 60 min at a speed of 600 rpm. After the grinding is completed, the suspension is collected and transferred to a 10ml EP tube, and diluted with water for injection to 100%, the osmotic pressure is adjusted to isotonicity with sodium chloride, and the pH value is adjusted to 7 with sodium citrate. The particle size and Zeta potential of the prepared suspension were measured after appropriate dilution. The volume average particle diameter is 756.2nm, and the Zeta potential ...
Embodiment 3
[0067] prescription:
[0068]
[0069] Preparation:
[0070] Weigh the prescribed amount of polyvinylpyrrolidone, Tween 80, and ZL004 and add them to the prescribed amount of water for injection, mix well, dissolve or swell the above-mentioned auxiliary materials to form a solution, then add them together with ZL004 to the planetary ball mill, mix Mix evenly to form a grinding material mixture, add 30 agate grinding beads with a diameter of 1.0 mm, put it in a planetary ball mill, and grind for 60 minutes at a speed of 600 rpm. After grinding, use sodium chloride to adjust the osmotic pressure to isotonicity, and use sodium citrate to adjust the pH value to 7. The particle size and Zeta potential of the prepared suspension were measured after appropriate dilution. The volume average particle diameter is 793.5nm, and the Zeta potential is -23.9mv.
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