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Application of aminomethylbenzoic acid composition in the treatment of tuberculosis

A technology of aminomethylbenzoic acid and its composition, which is applied in the field of active compounds of western medicines, can solve the problem of no aminomethylbenzoic acid inhibiting and killing Mycobacterium tuberculosis, and achieve the effects of shortening the course of medication, enhancing curative effect, and restoring activity

Active Publication Date: 2020-09-18
THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no literature report on the inhibition and killing of Mycobacterium tuberculosis by aminomethylbenzoic acid, and there is no literature report on the use of it in combination with cycloserine for the treatment of tuberculosis

Method used

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  • Application of aminomethylbenzoic acid composition in the treatment of tuberculosis
  • Application of aminomethylbenzoic acid composition in the treatment of tuberculosis
  • Application of aminomethylbenzoic acid composition in the treatment of tuberculosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Experimental study on the effect of aminomethylbenzoic acid combined with cycloserine on tuberculosis mice

[0018] 1. Replication of mouse tuberculosis model: 32 clean-grade KM mice, 8 weeks old, weighing 18-22 g, half male and half male. Select human-type Mycobacterium tuberculosis H37RV standard strain to infect mice, the specific method is to take 0.4mL containing 6.6×10 5 A suspension of Mycobacterium tuberculosis H37RV was injected into the tail vein of mice to establish a mouse model of tuberculosis.

[0019] 2. Grouping and administration: the tuberculosis model mice were randomly divided into the following four groups according to the method of male and female: CK group, CS group, AMBA group, CS+AMBA group, with 8 mice in each group. From the second day after the mice were infected with Mycobacterium tuberculosis H37RV, the mice in each administration group were intragastrically administered the corresponding drugs based on their body weight, twice ...

Embodiment 2

[0025] Embodiment 2: the preparation of aminomethylbenzoic acid / cycloserine tablet

[0026]

[0027] Preparation process: first put aminotoluic acid and mannitol into a mortar, grind and mix evenly, then add carboxymethyl starch sodium, compressible starch and mix evenly, finally add cycloserine and mix evenly, use 5% PVP absolute ethanol The solution is used as a binder for granulation, dried at 40°C, granulated, added with magnesium stearate, mixed evenly, and compressed into tablets.

Embodiment 3

[0028] Embodiment 3: the preparation of aminomethylbenzoic acid / cycloserine tablet

[0029]

[0030] Preparation process: first put aminotoluic acid and mannitol into a mortar, grind and mix evenly, then add carboxymethyl starch sodium, compressible starch and mix evenly, finally add cycloserine and mix evenly, use 5% PVP absolute ethanol The solution is used as a binder for granulation, dried at 40°C, granulated, added with magnesium stearate, mixed evenly, and compressed into tablets.

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Abstract

The invention discloses application of an aminomethylbenzoic acid composition in tuberculosis treatment, belonging to the technical field of medicines. The aminomethylbenzoic acid composition takes aminomethylbenzoic acid and cycloserine as active ingredients; the two ingredients achieve a synergistic effect, can quickly kill mycobacterium tuberculosis, and also can recover the activity of a tissue eroded by the mycobacterium tuberculosis to a certain extent. Besides, a medicine taking treatment course of a tuberculosis patient is greatly shortened by the aminomethylbenzoic acid composition, and the curative effect is enhanced; above all, when a drug is applied to the tuberculosis patient, only a quarter to one third of an original clinical dose needs to be taken, and thus the drug injures liver and kidney little.

Description

technical field [0001] The invention belongs to the technical field of active compounds of western medicines, and in particular relates to an aminomethylbenzoic acid pharmaceutical composition for treating tuberculosis and its application. Background technique [0002] Tuberculosis is one of the major public health problems facing the world today. Its pathogen is Mycobacterium tuberculosis, which belongs to the genus Mycobacterium. In recent years, due to the emergence of problems such as human immunodeficiency virus (HIV) combined with Mycobacterium tuberculosis infection and large-scale population movement, the epidemic situation of tuberculosis has aggravated. At present, about 9 million people worldwide develop active tuberculosis every year, and 2 to 3 million people die of tuberculosis. It is estimated that about 1 / 3 of the world's population is currently infected with Mtb, most of which are latent tuberculosis infections, that is, the body's immune system can control...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/195A61K31/42A61P31/06A61P11/00
CPCA61K31/195A61K31/42A61K2300/00
Inventor 张彩凤牛文一李明瑛万勇敢黄健张力公
Owner THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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