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Gradient separation and comprehensive utilization method of active ingredient of puffball

An active ingredient and gradient technology, which is applied in the field of gradient separation and comprehensive utilization of puffball active ingredients, can solve the problems of complex extraction process, high waste material and high comprehensive cost, and achieves high separation efficiency, high comprehensive benefit and simple preparation method. Effect

Active Publication Date: 2017-11-03
LIAOCHENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the pure monomer compounds isolated in the current research are mainly used for the purpose of structural identification, the quantity is small, the extraction process is complicated, there are many waste substances, and the overall cost is high, so it cannot be produced in large quantities to meet the needs of extensive pharmacological activity research and new product development. need

Method used

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  • Gradient separation and comprehensive utilization method of active ingredient of puffball
  • Gradient separation and comprehensive utilization method of active ingredient of puffball
  • Gradient separation and comprehensive utilization method of active ingredient of puffball

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Put 132g of puffball into a 5L four-neck round bottom flask, add 2.6L of absolute ethanol, install a reflux condenser, a thermometer, mechanically stir, heat to 60°C under stirring, and keep the temperature for 2 hours. Suction filtration while hot, and repeat the above operation for the filter residue, and carry out the second and third extractions. The obtained filtrate was concentrated with a rotary evaporator to obtain 2.3 g of extract, and the evaporated solvent was recovered and recycled. After the filter residue is dried, the remaining 130g is used as organic fertilizer.

Embodiment 2

[0034] Put 277g of puffball into a 5L four-neck round bottom flask, add 2.8L of absolute ethanol, install a reflux condenser, a thermometer, mechanically stir, heat to 70°C under stirring, and keep the temperature for 2 hours. Suction filtration while hot, and repeat the above operation for the filter residue, and carry out the second and third extractions. The obtained filtrate was concentrated with a rotary evaporator to obtain 4.8 g of extract, and the evaporated solvent was recovered and recycled. After the filter residue is dried, the remaining 273g is used as organic fertilizer.

Embodiment 3

[0036] Put 219g of puffball into a 5L four-necked round bottom flask, add 4L of absolute ethanol, install a reflux condenser, a thermometer, mechanically stir, heat to 65°C under stirring, and keep the temperature for 2 hours. Suction filtration while hot, and repeat the above operation for the filter residue, and carry out the second and third extractions. The obtained filtrate was concentrated with a rotary evaporator to obtain 3.9 g of extract, and the evaporated solvent was recovered and recycled. After the filter residue is dried, the remaining 216g is used as organic fertilizer.

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Abstract

The invention provides a gradient separation and comprehensive utilization method of an active ingredient of a puffball. The method comprises the following steps of: extracting the puffball with alcohol firstly to form a crude extract and extraction slag, performing evaporation and concentration on the crude extract to form alcohol and an extract, stepwise eluting the extract with solvents having different polarities to form different extraction parts, performing the evaporation and concentration on the different extraction parts to separate the solvents out to form a plurality of sub extracts, performing repeated stepwise elution on the sub extracts to form a single-component extract, and separating the solvents out of the single-component extract to form a pure monomeric compound. The crude extract, the extract, the various extraction parts, the sub extracts and the monomeric compound obtained by the method can serve as products of different levels for use according to different properties, and the extraction slag can also be used for manufacturing livestock feed, materials or organic fertilizer for edible mushroom cultivation and the like. The solvents can be evaporated and recycled. The method has a high utilization rate of the puffball, almost achieves zero discharge, and has no environmental pollution and high comprehensive benefits.

Description

technical field [0001] The invention belongs to the field of extraction and separation of active components of natural products, and in particular relates to a method for gradient separation and comprehensive utilization of puffball active components. Background technique [0002] Puffball belongs to fungal traditional Chinese medicine, commonly known as horseshoe bag, with various types and rich resources, and is widely distributed all over the world. The medicinal puffballs included in the Chinese Pharmacopoeia (2015 edition) are the dry fruiting bodies of the fungus Prunus officinalis, Puffball puffball and Purple puffball. In addition, there are dozens of species of puffballs such as the golden puffball of the Puffaceae fungus, the golden puffball, the light puffball, the yellow puffball, the earth star family, and the gray bag family, which are also used as medicine by the people. With the development of society, the scope of application of puffball has become wider an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C05F5/00A23K10/30A23K10/37
CPCA23K10/30A23K10/37C05F5/006Y02P60/87Y02A40/20
Inventor 曾庆华陈志晓张宪玺叶勇曾庆梅
Owner LIAOCHENG UNIV
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