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Textile-based reinforced degradable luminal stent and its preparation and application

An reinforced, textile-based technology, applied in the field of textile-based reinforced degradable lumen stents and their preparation, can solve the problems of low shear stress of the blood vessel wall, poor stent morphology and mechanical properties, activation of smooth muscle cells, etc. Radial support force, effective fixation, and the effect of preventing loose edges and off-line

Active Publication Date: 2019-06-04
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Molding makes the whole braided wire at the softening temperature be compressed and irreversibly deformed, and the cross section of the wire changes from circular or oval to a rectangular shape, which has adverse effects on the shape and mechanical properties of the stent. Clinical studies have shown that the rectangular cross section of the stent increases blood flow in The flow barrier at the junction of the vessel wall and the stent changes the form of blood flow and easily forms low shear stress on the vessel wall, which leads to adverse reactions such as thrombus and smooth muscle cell activation

Method used

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  • Textile-based reinforced degradable luminal stent and its preparation and application
  • Textile-based reinforced degradable luminal stent and its preparation and application
  • Textile-based reinforced degradable luminal stent and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] like figure 1 and figure 2As shown, a textile-based reinforced degradable luminal stent includes a hollow tubular fabric formed by two-dimensional and three-dimensional braiding of degradable polymer threads as braided threads 1, and two sets of braided threads 1 Introduce the axial thread 2, the axial thread 2 does not participate in the weaving, the axial thread 2 is melted through the heat treatment process, and the interweaving points of the two groups of degradable polymer threads are bonded and fixed by the molten axial thread 2, thereby obtaining a shape-stable Textile-based reinforced degradable luminal stent.

[0036] The preparation method of the textile-based reinforced degradable endoluminal stent is as follows:

[0037] Step 1: Make bobbins of two sets of braiding threads required for interweaving and place them on the yarn carrier of the 48-spindle two-dimensional spindle knitting machine; lead the axial threads through the through hole in the center of...

Embodiment 2

[0041] like figure 1 and figure 2 As shown, a textile-based reinforced degradable luminal stent includes a hollow tubular fabric formed by two-dimensional and three-dimensional braiding of degradable polymer threads as braided threads 1, and two sets of braided threads 1 Introduce the axial thread 2, the axial thread 2 does not participate in the weaving, the axial thread 2 is melted through the heat treatment process, and the interweaving points of the two groups of degradable polymer threads are bonded and fixed by the molten axial thread 2, thereby obtaining a shape-stable Textile-based reinforced degradable luminal stent.

[0042] The preparation method of the textile-based reinforced degradable endoluminal stent is as follows:

[0043] Step 1: Make bobbins of the two sets of braiding threads required for interweaving and place them on the yarn carrier of the 32-spindle two-dimensional spindle knitting machine; lead the axial threads through the through hole in the cent...

Embodiment 3

[0047] like figure 1 and figure 2 As shown, a textile-based reinforced degradable luminal stent includes a hollow tubular fabric formed by two-dimensional and three-dimensional braiding of degradable polymer threads as braided threads 1, and two sets of braided threads 1 are formed during the weaving process. Introduce the axial thread 2, the axial thread 2 does not participate in the weaving, the axial thread 2 is melted through the heat treatment process, and the interweaving points of the two groups of degradable polymer threads are bonded and fixed by the molten axial thread 2, thereby obtaining a shape-stable Textile-based reinforced degradable luminal stent.

[0048] The preparation method of the textile-based reinforced degradable endoluminal stent is as follows:

[0049] Step 1: Make bobbins of the two sets of braiding threads required for interweaving and place them on the yarn carrier of the 48-spindle two-dimensional spindle knitting machine; lead the axial threa...

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Abstract

The invention provides a textile-based enhanced degradable tube cavity support and a preparation method and application thereof. The textile-based enhanced degradable tube cavity support is characterized by comprising a hollow tubular fabric formed by two-dimensionally and three-directionally knitting degradable macromolecular silk yarns as knitting silk yarns, wherein axial silk yarns are introduced between two groups of knitting silk yarns in the knitting process and are not knitted, the axial silk yarns are molten through a heat treatment process, weaving points of the two groups of degradable macromolecular silk yarns are bonded and fixed through the molten axial silk yarns, and accordingly the textile-based enhanced degradable tube cavity support stable in shape is obtained. The shortcoming that the edge knitted by a machine is easy to loosen and a structure is not easy to fix can be effectively overcome, slippage of the weaving points of the support can be effectively prevented, the number of the weaving points per unit length when the support is radially compressed is increased, and the radial supporting force of the support is increased.

Description

technical field [0001] The invention relates to a textile-based reinforced degradable luminal stent and a preparation method thereof, in particular to a mechanically expandable implantable braided stent that can be used for stenotic diseases such as blood vessels, esophageal tubes, trachea, bile ducts, and intestinal tubes. its preparation method. Background technique [0002] Stent is currently the main method for the treatment of human luminal stenosis diseases. It is developed on the basis of luminal balloon dilation and molding, providing effective support at the lesion site and preventing long-term re-stenosis. Specifically, the luminal stent in the radially compressed state is positioned to the diseased part of the human lumen through the delivery system, and then the stent is released immediately, and its diameter is expanded with the help of a balloon or self-expanding, and it is in direct contact with the luminal wall. The radial support force of the stent provides...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/90
CPCA61F2/90A61F2002/821A61F2002/823A61F2210/0004A61F2230/0069A61F2240/002
Inventor 王富军赵帆王璐薛雯林婧关国平
Owner DONGHUA UNIV
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