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Rapid film forming fluid dressing containing N-glycosylated chitosan as well as preparation and application of rapid film forming fluid dressing

A chitosan and sugar-based technology is applied in the field of biomedical dressing and its preparation, which can solve the problems of pain, unfavorable wound healing, easy tearing and touching the wound surface, etc., and achieves good air permeability and water resistance, good biological safety, The effect of good biocompatibility

Inactive Publication Date: 2017-11-07
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional bandages consist of a long piece of adhesive plaster and a small piece of reticular woven absorbent cotton. Although it has the advantages of low price and convenient use, traditional bandages still have the following disadvantages: (1) poor air permeability, easy to make the skin around the wound Whitening and wrinkling, which is not conducive to wound healing; (2) The bandage is fixed around the wound by adhesive tape, and it is easy to tear and touch the wound when replacing it, and the wound granulation tissue is easy to grow into the mesh of the absorbent cotton, and the bandage adheres to the wound when replacing it. Cause secondary injury and bring pain to the patient; (3) cannot keep the wound moist and delay wound healing
At present, there are many kinds of antibacterial dressings based on chitosan, but the solubility of chitosan in water is extremely poor, which greatly limits its application.

Method used

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  • Rapid film forming fluid dressing containing N-glycosylated chitosan as well as preparation and application of rapid film forming fluid dressing
  • Rapid film forming fluid dressing containing N-glycosylated chitosan as well as preparation and application of rapid film forming fluid dressing
  • Rapid film forming fluid dressing containing N-glycosylated chitosan as well as preparation and application of rapid film forming fluid dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Preparation of N-glycosylated chitosan: Weigh 4.0g of chitosan, add 200mL of 1% acetic acid aqueous solution in volume concentration, and stir for 0.5h at room temperature (25-30°C). When it is fully dissolved, add 4.0 chitosan. Sugar amino equivalent fructose, after magnetic stirring reaction at 30~35℃ for 7h, add 1.7g sodium borohydride and reduce at room temperature for 24h, finally terminate the reaction with 95% volume concentration ethanol aqueous solution, and wash the precipitated product with absolute ethanol for 3~ After 4 times, the precipitate was obtained by centrifugation, and dried under vacuum at 40°C to obtain 7.5 g of N-glycosylated chitosan, which was stored in a desiccator for later use.

Embodiment 2

[0036] The fast film-forming fluid dressing containing N-glycosylated chitosan is made of the following raw materials:

[0037]

[0038] The specific steps of its preparation are:

[0039] (1) Preparation of the base solution: Weigh 0.2g of N-glycosylated chitosan and dissolve it in 5mL of 5mg / mL saline, then add 0.15mL of lactic acid and stir to dissolve to obtain a base solution with a concentration of 40mg / mL ;

[0040] (2) Preparation of membrane solution: Weigh 1g of polyvinyl alcohol (polymerization degree 1750±50), add it to 10mL of deionized water, heat and stir at 95℃ for 2~3h until it is completely dissolved, and obtain a mass concentration of 10% polyvinyl alcohol Membrane liquid

[0041] (3) Add the membrane solution prepared in step (2) to the bottom solution of step (1), mix the two evenly, and then add 0.2 mL of olive oil, 0.1 g of menthol, 0.5 mL of 30% hydrogen peroxide by volume and volume The concentration of 95% ethanol aqueous solution is 8 mL, the stirring spee...

Embodiment 3

[0043] The fast film-forming fluid dressing containing N-glycosylated chitosan has the following raw material composition and ratio:

[0044]

[0045] The preparation method is:

[0046] (1) Preparation of the base solution: Weigh 0.2g of N-glycosylated chitosan and dissolve it in 5mL of 5mg / mL saline, add 0.2mL of lactic acid and stir to dissolve to obtain a base solution with a concentration of 40mg / mL ;

[0047] (2) Preparation of membrane liquid: Weigh 1g of polyvinyl alcohol, add it to 10mL of deionized water, heat and stir at 95°C for 2 to 3 hours until it is completely dissolved, and obtain a 10% polyvinyl alcohol membrane liquid by mass concentration;

[0048] (3) Add the membrane solution prepared in step (2) to the bottom solution of step (1), mix the two evenly, add 0.3 mL of olive oil, 0.5 g of menthol, 1 mL of 30% hydrogen peroxide by mass concentration, and 95% by volume. % Ethanol aqueous solution 10mL, stirring speed 500r / min, stirring and mixing uniformly to obtain 2...

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Abstract

The invention discloses a rapid film forming fluid dressing containing N-glycosylated chitosan as well as preparation and application of the rapid film forming fluid dressing. The dressing is prepared from raw materials as follows: N-glycosylated chitosan, normal saline with concentration being 5 mg / mL, lactic acid, polyvinyl alcohol, deionized water, olive oil, menthol, hydrogen peroxide with mass concentration being 30% and aqueous ethanol with volume concentration being 95%. The dressing has effects of hemostasis, bacteriostasis and analgesia and the function of promoting wound healing and the like; the dressing has good breathability and waterproofness and is not limited by size, shape and location of a wound, and a formed film has certain elasticity, so that a coated part can move freely; the dressing is good in biocompatibility and biosecurity, is non-irritant and produces no allergy and other symptoms; the preparation technology is simple, the cost is low, and the dressing is convenient to carry and use.

Description

(1) Technical field [0001] The invention relates to a biomedical dressing and a preparation method thereof. (2) Background technology [0002] At present, in the medical field, people are still accustomed to using various bandages to care and repair wounds, and traditional bandages are the first choice for wound treatment. The traditional wound dressing is composed of a long strip of tape and a small piece of woven absorbent cotton. Although it has the advantages of low price and convenient use, the traditional wound dressing still has the following disadvantages: (1) Poor air permeability, easy to make the skin around the wound Whitening and wrinkling is not conducive to wound healing; (2) The bandage is fixed around the wound with tape, it is easy to tear and touch the wound when changing, and the wound granulation tissue is easy to grow into the mesh of absorbent cotton. When changing, the bandage adheres to the wound. Causes secondary injury and brings pain to the patient; (...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08B37/08
CPCA61L26/0014A61L26/0023A61L26/0057A61L26/0066A61L2300/106A61L2300/11A61L2300/21A61L2300/236A61L2300/30A61L2300/402A61L2300/404A61L2300/412A61L2300/45A61L2400/04C08B37/003C08L5/08C08L29/04
Inventor 易喻应国清徐云霞梅建凤陈建澍张彦璐
Owner ZHEJIANG UNIV OF TECH
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