Mesoporous magnesium silicate/polybutylene succinate composite scaffold as well as preparation method and application thereof

A technology of polybutylene succinate and polybutylene succinate, which is applied in the field of mesoporous magnesium silicate/polybutylene succinate composite scaffold and its preparation and application, can solve bone regeneration In order to solve the problems of slow osseointegration, poor osteogenic differentiation, and slow cell response, the pore size distribution can be adjusted, the adhesion can be promoted, and the operation is easy.

Inactive Publication Date: 2017-11-07
上海禾麦医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is to overcome the defects of slow cell response, poor osteogenic differentiation ability, insufficient nutrition and other defects of bone repair materials commonly used in the prior art, such as low activity, slow bone regeneration and osseointegration speed, etc., and provides a medium Porous magnesium silicate / polybutylene succinate composite scaffold and its preparation method and application

Method used

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  • Mesoporous magnesium silicate/polybutylene succinate composite scaffold as well as preparation method and application thereof
  • Mesoporous magnesium silicate/polybutylene succinate composite scaffold as well as preparation method and application thereof
  • Mesoporous magnesium silicate/polybutylene succinate composite scaffold as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0071] (1) Preparation of mesoporous magnesium silicate (m-MS)

[0072] First, place a mixed solution of 30mL deionized water and 120mL 2.0mol / L dilute hydrochloric acid in a 50°C water bath. Then, 4.0 g of P123 (EO20PO70EO20, 5800, Sigma Aldrich) was accurately weighed, added to the above mixed solution, and stirred for 30 minutes until clear. Subsequently, 4.8g magnesium nitrate hexahydrate (Mg(NO 3 ) 2 ·6H 2 O), accurately weighed 8.5g tetraethyl orthosilicate (TEOS) was added in the above-mentioned clear solution, and stirred for 5 hours. After standing still, filter with suction, wash with deionized water, and filter with suction again, repeat 3 times, and place in a 60°C electric blast drying oven (DHG-9070A, Shanghai Yiheng Scientific Instrument Co., Ltd.) to obtain a white powder. Put the powder into a stainless steel mold, and use a tablet press (YP-15t, Tianjin Jinfulun Technology Co., Ltd.) to make a disc sample (Φ12×2mm) under a pressure of 2 MPa. Finally, the...

Embodiment 2

[0076] Accurately weigh 0.6 g of PBSu with a weighing bottle, and dissolve it in 2 mL of dimethylformamide solution. Add 0.4g of the mesoporous magnesium silicate (m-MS) powder prepared in Example 1 and keep stirring to make it uniformly dispersed, after fully mixing, add 8g of sodium chloride particles (particle size is 300-500 μm), mix and stir for 10 minute. Then the above mixture was added into a stainless steel mold, under the pressure of 0.2MP, pressed for 2 minutes. The obtained samples were dried naturally in a fume hood for 12 hours to evaporate the solvent. The material was then soaked in deionized water for 48 hours to remove the porogen (sodium chloride particles), and the deionized water was changed every 8 hours. Finally, the sample was placed in an oven at 37°C for 12 hours to obtain bone repair scaffold material C40.

Embodiment 3

[0078] (1) Preparation of mesoporous magnesium silicate (m-MS)

[0079] First, place a mixed solution of 40mL deionized water and 130mL 2.5mol / L dilute hydrochloric acid in a water bath at 45°C. Then, 5.0 g of P123 (EO20PO70EO20, 5800, Sigma Aldrich) was accurately weighed, added to the above mixed solution, and stirred for 30 minutes until clear. Subsequently, weigh 5.0g magnesium nitrate hexahydrate (Mg(NO 3 ) 2 ·6H 2O), accurately weighed 8.7g tetraethyl orthosilicate (TEOS) was added in the above-mentioned clear solution, and stirred for 6 hours. After standing still, filter with suction, wash with deionized water, and filter with suction again, repeat 3 times, and place in a 60°C electric blast drying oven (DHG-9070A, Shanghai Yiheng Scientific Instrument Co., Ltd.) to obtain a white powder. Put the powder into a stainless steel mold, and use a tablet press (YP-15t, Tianjin Jinfulun Technology Co., Ltd.) to make a disc sample (Φ12×2mm) under a pressure of 2 MPa. Fina...

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Abstract

The invention discloses a mesoporous magnesium silicate/polybutylene succinate composite scaffold as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) mixing polybutylene succinate with an organic solvent, so as to obtain a mixture I; (2) mixing mesoporous magnesium silicate and a pore-foaming agent with the mixture I in the step (1), so as to obtain a mixture II; and (3) compressing the mixture II in the step (2), removing the organic solvent, and removing the pore-foaming agent, and drying. By utilizing the mesoporous magnesium silicate/polybutylene succinate composite scaffold, the adhesion and proliferation of an MC3T3-E1 cell and activity expression of ALP can be obviously promoted, and in-vivo osteogenesis can be promoted. The preparation method is simple and convenient in operation, and the prepared mesoporous magnesium silicate/polybutylene succinate composite scaffold has good pore connectivity, uniform aperture and excellent in-vitro degradability and biological activity and is capable of releasing silicon and magnesium ions and beneficial to osteoblastic differentiation.

Description

technical field [0001] The invention relates to a mesoporous magnesium silicate / polybutylene succinate composite support and a preparation method and application thereof. Background technique [0002] Due to natural disasters, traffic accidents, orthopedic diseases and population aging, the integrity of bone structure is destroyed, and the number of clinical bone defects is increasing. Traditional treatment methods, including autologous bone grafting and allogeneic bone grafting, have limitations in material sources and potential risks. Therefore, more and more people have developed and studied artificially synthesized bone substitute biomaterials. [0003] Due to slow cell response, poor osteogenic differentiation ability and insufficient nutrition, the commonly used bone repair materials present prominent problems such as low activity, slow bone regeneration and osseointegration. For example, organic / organic composites such as chitosan / PBSu have relatively poor in vitro ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/56A61L27/50
CPCA61L27/446A61L27/50A61L27/56A61L2430/02C08L67/04
Inventor 苏佳灿苏奕铭魏杰
Owner 上海禾麦医学科技有限公司
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