Preparation method for single-layer coated water-soluble superparamagnetic ferroferric oxide nano-particle

A ferroferric oxide and superparamagnetic technology, which is applied in the fields of biomedicine, nanomaterials and bioengineering, can solve the problems of poor water solubility and achieve the effect of improving water solubility

Active Publication Date: 2017-11-14
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

relative to other Fe 3 o 4 The preparation method of nanoparticles, the magnetic nanoparticles prepared by high temperature pyrolysis have the characteristics of good crystal form, good dispersion and uniform particle size distribution, but their water solubility is poor, which limits its application in biomedicine and other fields

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Preparation of oil-soluble superparamagnetic ferric oxide nanoparticles by high temperature pyrolysis: 0.706g iron acetylacetonate, 0.565g oleic acid, 0.535g oleylamine and 20mL diphenyl ether were mixed and stirred evenly under nitrogen protection, and gradually Raise the temperature to 265°C and react for 1 hour to generate 4nm superparamagnetic ferric oxide nanoparticles with a particle size of 1, and use this method to prepare superparamagnetic ferric oxide nanoparticles with a particle size of 12nm as seeds. Paramagnetic Fe3O4 nanoparticles;

[0022](2) Preparation of succinoheparin: 1.0 g of heparin sodium was dissolved in 5 mL of water, and the solution was permeated through an acidified gel column (H+ form, 200 mL), and then the pH of the solution was adjusted to 7.0, the solution was lyophilized to obtain heparin tributylammonium salt (1.5 g). The tributylammonium salt (1.5g) was dissolved in 30mL of dry solvent N, N dimethylformamide (DMF), under the prot...

Embodiment 2

[0025] (1) with embodiment 1;

[0026] (2) with embodiment 1;

[0027] (3) Preparation of water-soluble superparamagnetic ferric oxide nanoparticles coated by a single layer: the superparamagnetic ferric ferric oxide nanoparticles obtained in 20mg (1) step were dissolved in 50mL dry solvent chloroform, and Add 50 mg of the tributylammonium salt of succinoheparan obtained in the step (2) to the reaction solution, stir at room temperature for 72 hours, and separate with a magnet to obtain a black solid, which is washed twice with an appropriate amount of hexane and dichloromethane , and finally, the formed monolayer-coated water-soluble superparamagnetic ferric oxide nanoparticles are kept in deionized water for use.

Embodiment 3

[0029] (1) High-temperature pyrolysis method prepares oil-soluble superparamagnetic ferric oxide nanoparticles: 0.706g iron acetylacetonate, 0.565g oleic acid, 0.535g oleylamine and 20mL bibian ether are mixed and stirred evenly under nitrogen protection, and gradually Heating up to 300°C and reacting for 3 hours, a 6nm superparamagnetic ferric oxide nanoparticle with a particle diameter of 1 is generated, and using this method, a superparamagnetic ferric oxide nanoparticle with a particle diameter of 14nm is prepared as a seed. Paramagnetic iron ferric oxide nanoparticles; with embodiment 1;

[0030] (2) Preparation of water-soluble superparamagnetic ferric oxide nanoparticles coated with a single layer: the superparamagnetic ferric oxide nanoparticles of 30mg (1) step gained were dissolved in 40mL dry solvent chloroform, and Add 40 mg of the tributylammonium succinoheparan salt obtained in the step (2) to the reaction solution, stir at room temperature for 72 hours, and sepa...

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Abstract

The invention discloses a preparation method for a single-layer coated water-soluble superparamagnetic ferroferric oxide nano-particle and belongs to the technical field of nanometer materials and bioengineering. The method comprises the following steps: firstly, adopting a high-temperature pyrolytic process for compounding the superparamagnetic ferroferric oxide nano-particle and using multi-bond polymer with a large quantity of carboxyl groups for modifying the surface of the oil-soluble nano-particle, thereby acquiring the water-soluble ferroferric oxide nano-particle with water solubility and dynamic radius only increasing by 1-2nm. The modified magnetic nano-particle has uniform shape, excellent dispersity and high biocompatibility. The preparation method has the advantages of simple and feasible operation, high repeatability, and the like; the prepared water-soluble superparamagnetic ferroferric oxide nano-particle has a better imaging effect; the special groups on the surface thereof can be conveniently combined with the other biotic factors; a basis is established for the application of the nano-particle in the biomedicine fields, such as, magnetic resonance imaging, drug magnetic targeting transferring, magnetic thermal therapy, magnetic separation, and the like.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials and bioengineering, in particular to a method for preparing monolayer-coated water-soluble superparamagnetic iron ferric oxide nanoparticles, and belongs to the field of biomedicine. Background technique [0002] Nanotechnology refers to the technology of studying the structure of matter and its changing law in the nanometer range, and applying it to production and life. Nanoparticles are also called ultrafine particles, which generally refer to particles with a size between 1-100nm, which are in the transition zone between atomic clusters and macroscopic objects. This type of microscopic system is not a typical macroscopic system, but a typical mesoscopic system. Nanomaterials are in the transition region from a single atom to a bulk material, which causes variations in its surface electronic structure and crystal structure, which makes it have special effects that distinguish bulk materia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G49/08H01F1/00B82Y30/00B82Y40/00
CPCB82Y30/00B82Y40/00C01G49/08C01P2004/64H01F1/0018
Inventor 王毅庆谢曼曼卢乾王建全张旭东倪轲娜顾毅旭
Owner NANJING UNIV
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